Abstract
Male breast cancer is a rare disease, accounting for less than 1% of all cases of breast cancer. However, the incidence of male breast cancer is increasing. In this study, we systematically analyzed the cases of male breast cancer and evaluated the management of operable male breast cancer in daily clinical practice according to the international clinical guidelines. Data of male breast cancer characteristics and management were recorded from our electronic database. We present a case series of male breast cancer patients treated at our institution between 2013 and 2021 and summarize the recommendations on management of male patients with breast cancer. Twenty-six patients met the search criteria. The majority of tumors were hormone-receptor positive and human epidermal growth factor receptor 2 negative. Two tumors were derived from axillary accessory breast. All patients underwent mastectomy. Fifteen patients received adjuvant chemotherapy containing anthracycline or taxane. Ten patients received adjuvant radiotherapy for lymph node metastasis. Twenty-five patients received adjuvant endocrine therapy. None of patients received anti-human epidermal growth factor receptor 2 therapy. During the median follow-up period of 37 months, one patient died of previous lung cancer recurrence and one patient developed lung metastases 2 years after breast surgery. No recurrence or distant metastasis occurred in the other twenty-four patients. The incidence of male breast cancer is low. In this study, we present twenty-six cases of male patients with operable breast cancer in our department. All of them received surgery and adjuvant treatment. Early diagnosis and combined therapy benefit male patients with breast cancer. Surgery together with adjuvant treatment can bring a good prognosis.
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Introduction
Breast cancer is the most common malignancy among women worldwide [1]. Compared to female breast cancer, the incidence of male breast cancer is low, accounting for less than 1% of all cases of breast cancer [2]. The incidence of male breast cancer is also low in all male malignancies. However, the incidence of male breast cancer is increasing with growing rate of male gynecomastia [2]. With the low incidence, there were no large-scale prospective randomized clinical trials conducted to determine effective therapy for male patients. Diagnostic and treatment evidence for male breast cancer is limited. Currently, male breast cancer is treated similar to female breast cancer [3, 4]. For the different pathogenesis of male breast cancer and lack of knowledge about male breast cancer, the prognosis of male patients with breast cancer is worse than that of female patients [5, 6, 7]. In the present paper, we present a case series of male patients diagnosed with breast cancer treated at Department of Breast Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, between 2013 and 2021. We systematically analyzed the cases of male breast cancer and evaluated the management of operable male breast cancer according to the international clinical guidelines.
Patients and Methods
Operable male patients with breast cancer were selected from electronic database by using the search criteria of “breast cancer” and “male” between January 1, 2013, and December 31, 2021. Patients with distant metastasis were excluded. Patients and tumor characteristics, treatment, and follow-ups were collected. Data were analyzed applying descriptive statistics. The study was approved by the ethics committee of Hwa Mei Hospital, University of Chinese Academy of Sciences.
Result
Twenty-six patients matched the search criteria in the period between January 1, 2013, and December 31, 2021. The average age of the patients was 60 (from 37 to 82) years. About 58% of the patients were elderly men over 60 years old. Twenty-four cases of breast cancer were derived from breast, and the other two cases were derived from axillary accessory breast. Twenty-four cases underwent mastectomy, and two cases underwent accessory mastectomy. Fourteen patients received axillary lymph nodes dissection for metastasis or suspected metastasis of axillary lymph nodes, among whom two patients did not develop axillary lymph nodes metastasis. Pathology of twenty-one cases was invasive ductal carcinoma with three cases of ductal carcinoma in situ and two cases of mucinous carcinoma. Twenty-five cases were luminal type breast cancer with ten cases of luminal A and fifteen cases of luminal B. Only one case was triple negative breast cancer. In staging, there were three cases in stage 0, eight cases in stage I, ten cases in stage II, and five cases in stage III.
Fifteen patients received adjuvant chemotherapy. Nine patients received eight cycles of chemotherapy containing anthracycline and taxane, and the other six patients received four cycles of chemotherapy containing taxane. Ten patients received adjuvant radiotherapy for lymph nodes metastasis. Twenty-five patients received adjuvant endocrine therapy, including tamoxifen for twenty-one patients and gonadotropin-releasing hormone agonist (GnRHa) combined with aromatase inhibitor (AI) for four patients. All cases were human epidermal growth factor receptor 2 (HER2) negative breast cancer. None of patients received anti-HER2 therapy. During the median follow-up period of 37 months, one patient died of previous lung cancer recurrence (he received lung cancer surgery 2 years before breast cancer surgery. Lung cancer and breast cancer were both primary cancer), and one patient developed lung metastases 2 years after breast surgery. No recurrence or distant metastasis occurred in the other twenty-four patients. The survival time of the death case after breast surgery was 26 months. Details were listed in Table 1.
Discussion
The incidence of male breast cancer is low, accounting for less than 1% of all cases of breast cancer. However, the incidence of male breast cancer is increasing with growing rate of male gynecomastia in recent years [2]. Most male breast cancer occurs in elderly men [2, 4, 6]. Here, we describe the diagnosis and treatment of male breast cancer based on clinical guidelines and our case series.
The diagnosis of male breast cancer is similar to that of female breast cancer. Pathology is the gold standard [8]. Physical examination, ultrasound, mammography, and magnetic resonance help make clinic diagnosis. Physical examination included palpation of breast masses and axillary lymph nodes. The size, consistency, boundary, and mobility of tumor should be assessed. Male breast cancer is usually a hard mass with ill defined margins and poor mobility [9]. Ultrasound and mammography are routine preoperative examinations for breast diseases. Under breast ultrasound, male breast cancer is usually a mass with unclear boundaries, incomplete capsule, and abundant vascular supplication [10]. Mammography is difficult to carry out in male patients. Experienced mammography technicians are required to operate on account of a certain amount of breast tissue. Breast cancer in mammography is characterized by high density mass, unclear boundaries, and burrs [11]. For most patients, enhanced magnetic resonance is less available than ultrasound and mammography. It costs more and takes more time to receive enhanced magnetic resonance. In enhanced magnetic resonance, male breast cancer is characterized by irregular shape and enhanced signal of lesion [12]. Based on the above examination, we make the diagnosis of male breast cancer in clinic. Histopathological examination is required to make the final diagnosis.
Surgery
Surgery is the main treatment for early operable male breast cancer [13]. Mastectomy is the most common surgery for male patients with breast cancer. Sentinel lymph node biopsy can be applied for patients whose axillary lymph nodes are considered negative clinically. If the sentinel lymph nodes are negative, axillary lymph nodes dissection could be avoided. If the sentinel lymph nodes are positive, the surgeon may continue axillary lymph node dissection [14, 15]. Modified radical mastectomy (mastectomy + axillary lymph nodes dissection) is used for patients with suspected metastasis of axillary lymph nodes. Evidence shows that breast conserving surgery for male patients with breast cancer is feasible under the condition that the margin is negative and patients have the desire to receive breast conserving surgery [16, 17, 18]. However, in clinical practice, most of the male patients with breast cancer have limited breast tissue concentrated under nipple and areola, leading to breast mass located near the nipple. Those patients lose the chance of breast conserving surgery. Also, majority of male patients with breast cancer do not have a strong desire to undergo a breast conserving surgery in our experience. All patients in our case series received mastectomy or accessory mastectomy.
Chemotherapy
The application of chemotherapy in male patients with breast cancer is similar to that of female patients. The prognosis of male breast cancer is worse than that of female breast cancer. Male sex is a risk factor of prognosis [2, 13]. In our experience, chemotherapy is an important therapy for male patients with breast cancer. We should make a careful consideration before avoiding chemotherapy for male patients with breast cancer except for ductal carcinoma in situ or favorable histologic types such as pure tubular carcinoma and pure mucinous carcinoma. Between 1974 and 1988, a prospective study of adjuvant chemotherapy in male breast cancer was conducted by the American National Cancer Institute. Thirty-one male patients with breast cancer and lymph nodes metastasis were enrolled. The result showed that the 5-year, 10-year, and 20-year survival rates of patients undergoing adjuvant chemotherapy were 80%, 65%, and 42%, respectively, superior to historical control [19]. An observational cohort study showed that adjuvant chemotherapy for male patients with breast cancer could improve the prognosis [20]. Oncotype DX and other gene prognostic models could be applied to assess risk of distant recurrence and help clinician decide whether adjuvant chemotherapy is necessary for hormone receptor positive male breast cancer patients [21]. In our study, most patients (15 out of 21) with invasive ductal carcinoma received four to eight cycles of chemotherapy containing anthracycline or taxane. Most of them achieved good prognosis during the follow-up period.
Endocrine Therapy
In our retrospective study, 96% of male breast cancer is hormone receptor positive breast cancer. Tamoxifen is the gold standard of endocrine therapy for male patients with hormone receptor positive breast cancer [22, 23]. If tamoxifen is contraindicated, AI combined with gonadotropin-releasing hormone agonist could be a choice. AI monotherapy cannot be used in male patients with breast cancer. AI monotherapy plays an opposite role due to negative feedback regulation [24]. There is no evidence showing that GnRHa plus AI is superior to tamoxifen in male breast cancer [13]. As a selective estrogen receptor degrader, fulvestrant has been proved to be effective in the treatment of male breast cancer [25]. However, the guideline does not recommend use of fulvestrant as adjuvant therapy for male patients with breast cancer [26]. Cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors also have not been recommended to be used in adjuvant therapy for male patients with breast cancer [26]. In our study, most male patients with breast cancer received tamoxifen monotherapy and achieved good results.
Radiotherapy
The adjuvant radiotherapy applied to male breast cancer is similar to that used for female patients with breast cancer. Adjuvant radiotherapy is recommended for patients with axillary lymph node metastasis or undergoing breast conserving surgery. Postoperative radiotherapy is also recommended for patients with tumors larger than 5 cm [13, 26]. Those patients need to receive chest wall and related lymph node drainage area radiotherapy. An observational study showed that male patients with breast cancer and lymph nodes metastasis benefited from radiotherapy [27]. In our study, almost all the patients with lymph nodes metastasis received radiotherapy except for 3 patients with poor tolerance (2 patients were over 80 years old and 1 patient had psychiatric illness).
Targeted therapy
For HER2 positive male patients, adjuvant targeted therapy combining trastuzumab is required. Similar to female breast cancer, clinician recommends trastuzumab for lymph node negative HER2 positive patients and trastuzumab plus pertuzumab for lymph nodes positive HER2 positive patients. Male patients with other high risk of recurrence (such as T > 5 cm, age < 35) could be recommended trastuzumab plus pertuzumab [3, 5, 13, 14]. However, the rate of HER2 overexpression in male breast cancer is low. In our study, none of the 26 male patients got HER2 positive breast cancer, and none of them received anti-HER2 therapy.
We have searched the PubMed for case series of male breast cancer published in the last decade. Twenty-four retrospective studies are found [3, 28-50]. Some data was collected from last four decades with missing or not available information. Male breast cancer is rare. Most case series from single center contained less than twenty patients. Data of large-scale studies come from multicenter or national database. Like our study, most studies showed male patients with breast cancer have ER or PR positive and HER2 negative disease. One study showed 52.4% HER2 positive disease in 69 patients [31]. It is interesting for such high percentage of HER2 positive disease. More attention should be paid to find the reasons. Ki-67 value was reported in five studies with different cut-off values (20% in three studies and 14% in two studies) [31, 33, 40, 42, 45]. We select 20% as Ki-67 cut-off value to build Table 2. Our study showed 17/26 patients had lower Ki-67 value (≤ 20%), while two of five studies showed more patients had higher Ki-67 values [33, 42]. It showed male patients with breast cancer did not mean high Ki-67 values. Details are listed in Table 2.
Conclusion
The incidence of male breast cancer is low. In this study, we present twenty-six cases of male patients with operable breast cancer in our department. All of them received surgery and adjuvant treatment. During the median follow-up period of 37 months, most patients do not have recurrence or distant metastasis disease. Early diagnosis and combined therapy benefit male patients with breast cancer. Surgery together with adjuvant treatment can bring a good prognosis.
Data Availability
The datasets generated and analyzed during the current study are not publicly available for our institutional electronic database is not open to the public but are available from the corresponding author on reasonable request.
Abbreviations
- GnRHa:
-
Gonadotropin-releasing hormone agonist
- AI:
-
Aromatase inhibitor
- HER2:
-
Human epidermal growth factor receptor 2
- ER:
-
Estrogen-receptor
- PR:
-
Progesterone-receptor
- FISH:
-
Fluorescence in situ hybridization
- NA:
-
Not available
References
Globocan. Breast cancer fact sheet (2020) Available from: http://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf. Accessed 1 Jan 2022
Abdelwahab Yousef AJ (2017) Male breast cancer: epidemiology and risk factors. Semin Oncol 44(4):267–272. https://doi.org/10.1053/j.seminoncol.2017.11.002
Chhabra MK, Chintamani MK et al (2019) Male breast cancer-an Indian multicenter series of 106 cases. Indian J Surg 83(Suppl 2):333–340
Liu N, Johnson KJ, Ma CX (2018) Male breast cancer: an updated surveillance, epidemiology, and end results data analysis. Clin Breast Cancer 18(5):e997–e1002. https://doi.org/10.1016/j.clbc.2018.06.013
Mattson J, Vehmanen L (2016) Miehen rintasyöpä [Male breast cancer]. Duodecim 132(7):627–31. Finnish
Leon-Ferre RA, Giridhar KV, Hieken TJ, Mutter RW, Couch FJ, Jimenez RE, Hawse JR, Boughey JC, Ruddy KJ (2018) A contemporary review of male breast cancer: current evidence and unanswered questions. Cancer Metastasis Rev 37(4):599–614. https://doi.org/10.1007/s10555-018-9761-x
Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, Elias AD, Baskin-Bey ES, Cardoso F (2019) Male breast cancer: a disease distinct from female breast cancer. Breast Cancer Res Treat 173(1):37–48. https://doi.org/10.1007/s10549-018-4921-9
Nofal MN, Yousef AJ (2019) The diagnosis of male breast cancer. Neth J Med 77(10):356–359
Goss PE, Reid C, Pintilie M, Lim R, Miller N (1999) Male breast carcinoma: a review of 229 patients who presented to the Princess Margaret Hospital during 40 years: 1955–1996. Cancer 85(3):629–639. https://doi.org/10.1002/(sici)1097-0142(19990201)85:3%3c629::aid-cncr13%3e3.0.co;2-v
Mainiero MB, Lourenco AP, Barke LD, Argus AD, Bailey L, Carkaci S, D’Orsi C, Green ED, Holley SO, Jokich PM, Lee SJ, Mahoney MC, Moy L, Slanetz PJ, Trikha S, Yepes MM, Newell MS (2015) ACR appropriateness criteria evaluation of the symptomatic male breast. J Am Coll Radiol 12(7):678–682. https://doi.org/10.1016/j.jacr.2015.03.024
Doyle S, Steel J, Porter G (2011) Imaging male breast cancer. Clin Radiol 66(11):1079–1085. https://doi.org/10.1016/j.crad.2011.05.004
Shin K, Martaindale S, Whitman GJ (2019) Male breast magnetic resonance imaging: when is it helpful? Our experience over the last decade. Curr Probl Diagn Radiol 48(3):196–203. https://doi.org/10.1067/j.cpradiol.2018.01.002
Giordano SH (2018) Breast cancer in men. N Engl J Med 378(24):2311–2320. https://doi.org/10.1056/NEJMra1707939
Cardoso F, Bartlett JMS, Slaets L, van Deurzen CHM, van Leeuwen-Stok E, Porter P, Linderholm B, Hedenfalk I, Schröder C, Martens J, Bayani J, van Asperen C, Murray M, Hudis C, Middleton L, Vermeij J, Punie K, Fraser J, Nowaczyk M, Rubio IT, Aebi S, Kelly C, Ruddy KJ, Winer E, Nilsson C, Lago LD, Korde L, Benstead K, Bogler O, Goulioti T, Peric A, Litière S, Aalders KC, Poncet C, Tryfonidis K, Giordano SH (2018) Characterization of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program. Ann Oncol 29(2):405–417. https://doi.org/10.1093/annonc/mdx651
Fentiman IS (2018) Surgical options for male breast cancer. Breast Cancer Res Treat 172(3):539–544. https://doi.org/10.1007/s10549-018-4952-2
Cloyd JM, Hernandez-Boussard T, Wapnir IL (2013) Outcomes of partial mastectomy in male breast cancer patients: analysis of SEER, 1983–2009. Ann Surg Oncol 20(5):1545–1550. https://doi.org/10.1245/s10434-013-2918-5
Zaenger D, Rabatic BM, Dasher B, Mourad WF (2016) Is breast conserving therapy a safe modality for early-stage male breast cancer? Clin Breast Cancer 16(2):101–104. https://doi.org/10.1016/j.clbc.2015.11.005
Bateni SB, Davidson AJ, Arora M, Daly ME, Stewart SL, Bold RJ, Canter RJ, Sauder CAM (2019) Is breast-conserving therapy appropriate for male breast cancer patients? A National Cancer Database analysis. Ann Surg Oncol 26(7):2144–2153. https://doi.org/10.1245/s10434-019-07159-4
Walshe JM, Berman AW, Vatas U, Steinberg SM, Anderson WF, Lippman ME, Swain SM (2007) A prospective study of adjuvant CMF in males with node positive breast cancer: 20-year follow-up. Breast Cancer Res Treat 103(2):177–183. https://doi.org/10.1007/s10549-006-9363-0
Patel HZ 2nd, Buzdar AU, Hortobagyi GN (1989) Role of adjuvant chemotherapy in male breast cancer. Cancer 64(8):1583–1585. https://doi.org/10.1002/1097-0142(19891015)64:8%3c1583::aid-cncr2820640804%3e3.0.co;2-q
Grenader T, Yerushalmi R, Tokar M, Fried G, Kaufman B, Peretz T, Geffen DB (2014) The 21-gene recurrence score assay (Oncotype DX™) in estrogen receptor-positive male breast cancer: experience in an Israeli cohort. Oncology 87(1):1–6. https://doi.org/10.1159/000360793
Mauras N, O’Brien KO, Klein KO, Hayes V (2000) Estrogen suppression in males: metabolic effects. J Clin Endocrinol Metab 85(7):2370–2377. https://doi.org/10.1210/jcem.85.7.6676
Eggemann H, Ignatov A, Smith BJ, Altmann U, von Minckwitz G, Röhl FW, Jahn M, Costa SD (2013) Adjuvant therapy with tamoxifen compared to aromatase inhibitors for 257 male breast cancer patients. Breast Cancer Res Treat 137(2):465–470. https://doi.org/10.1007/s10549-012-2355-3
Hayes FJ, Seminara SB, Decruz S, Boepple PA, Crowley WF Jr (2000) Aromatase inhibition in the human male reveals a hypothalamic site of estrogen feedback. J Clin Endocrinol Metab 85(9):3027–3035. https://doi.org/10.1210/jcem.85.9.6795
Zagouri F, Sergentanis TN, Chrysikos D, Dimopoulos MA, Psaltopoulou T (2015) Fulvestrant and male breast cancer: a pooled analysis. Breast Cancer Res Treat 149(1):269–275. https://doi.org/10.1007/s10549-014-3240-z
National Comprehensive Cancer Network (2020) Available from: https://www.nccn.org/professionals/physician_gls/default.aspx#breast. Accessed 29 Dec 2020
Abrams MJ, Koffer PP, Wazer DE, Hepel JT (2017) Postmastectomy radiation therapy is associated with improved survival in node-positive male breast cancer: a population analysis. Int J Radiat Oncol Biol Phys 98(2):384–391. https://doi.org/10.1016/j.ijrobp.2017.02.007
Aggarwal A, Adepoju B, Yacur M, Maron D, Sharma MC (2021) Gender disparity in breast cancer: a veteran population-based comparison. Clin Breast Cancer 21(4):e471–e478. https://doi.org/10.1016/j.clbc.2021.01.013
Lomma C, Chan A, Chih H, Reid C, Peter W (2021) Male breast cancer in Australia. Asia Pac J Clin Oncol 17(2):e57–e62. https://doi.org/10.1111/ajco.13299
Johnson AE, Coopey SB, Spring LM et al (2021) Management and outcomes of men diagnosed with primary breast cancer. Breast Cancer Res Treat 188:561–569. https://doi.org/10.1007/s10549-021-06174-y
Pellini F, Granuzzo E, Urbani S, Mirandola S, Caldana M, Lombardi D, Fiorio E, Mandarà M, Pollini GP (2020) Male breast cancer: surgical and genetic features and a multidisciplinary management strategy. Breast Care (Basel) 15(1):14–20. https://doi.org/10.1159/000501711
Yetkin G, Celayir MF, Tanik C, Citgez B, Uludag M, Mihmanli M (2019) Male breast cancer: a 10 year retrospective case series in a tertiary care hospital. J Pak Med Assoc 69(8):1209–1212
Oana Cristina V, Monica Mihaela C, Daniel I, Maria S, Adrian Vasile D, Oana Mari P, Dan-Corneliu J, Adriana Elena N (2018) Histology of male breast lesions. Series of cases and literature review. Maedica (Bucur) 13(3):196–201. https://doi.org/10.26574/maedica.2018.13.3.196
Wan BA, Ganesh V, Zhang L, Sousa P, Drost L, Lorentz J, Vesprini D, Lee J, Rakovitch E, Lu FI, Eisen A, Yee C, Lam H, Chow E (2018) Treatment outcomes in male breast cancer: a retrospective analysis of 161 patients. Clin Oncol (R Coll Radiol) 30(6):354–365. https://doi.org/10.1016/j.clon.2018.02.026
Weir J, Zhao YD, Herman T, Algan Ö (2018) Clinicopathologic features and radiation therapy utilization in patients with male breast cancer: a National Cancer Database study. Breast Cancer (Auckl) 20(12):1178223418770687. https://doi.org/10.1177/1178223418770687
McKinley N, McCain S, Kirk S (2017) Long term follow up of male breast cancer. Ulster Med J 86(3):177–180
Rayne S, Schnippel K, Thomson J, Reid J, Benn C (2017) Male breast cancer has limited effect on survivor’s perceptions of their own masculinity. Am J Mens Health 11(2):246–252. https://doi.org/10.1177/1557988316631512
Vermeulen MA, Slaets L, Cardoso F, Giordano SH, Tryfonidis K, van Diest PJ, Dijkstra NH, Schröder CP, van Asperen CJ, Linderholm B, Benstead K, Foekens R, Martens JWM, Bartlett JMS, van Deurzen CHM (2017) Pathological characterisation of male breast cancer: results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program. Eur J Cancer 82:219–227. https://doi.org/10.1016/j.ejca.2017.01.034
Madden NA, Macdonald OK, Call JA, Schomas DA, Lee CM, Patel S (2016) Radiotherapy and male breast cancer: a population-based registry analysis. Am J Clin Oncol 39(5):458–462. https://doi.org/10.1097/COC.0000000000000078
Masci G, Caruso M, Caruso F, Salvini P, Carnaghi C, Giordano L, Miserocchi V, Losurdo A, Zuradelli M, Torrisi R, Di Tommaso L, Tinterri C, Testori A, Garcia-Etienne CA, Gatzemeier W, Santoro A (2015) Clinicopathological and immunohistochemical characteristics in male breast cancer: a retrospective case series. Oncologist 20(6):586–592. https://doi.org/10.1634/theoncologist.2014-0243
Bradley KL, Tyldesley S, Speers CH, Woods R, Villa D (2014) Contemporary systemic therapy for male breast cancer. Clin Breast Cancer 14(1):31–39. https://doi.org/10.1016/j.clbc.2013.09.001
Iorfida M, Bagnardi V, Rotmensz N, Munzone E, Bonanni B, Viale G, Pruneri G, Mazza M, Cardillo A, Veronesi P, Luini A, Galimberti V, Goldhirsch A, Colleoni M (2014) Outcome of male breast cancer: a matched single-institution series. Clin Breast Cancer 14(5):371–377. https://doi.org/10.1016/j.clbc.2014.02.008
Rushton M, Kwong A, Visram H, Graham N, Petrcich W, Dent S (2014) Treatment outcomes for male breast cancer: a single-centre retrospective case-control study. Curr Oncol 21(3):e400–e407. https://doi.org/10.3747/co.21.1730
Fogh S, Kachnic LA, Goldberg SI, Taghian AG, Powell SN, Hirsch AE (2013) Localized therapy for male breast cancer: functional advantages with comparable outcomes using breast conservation. Clin Breast Cancer 13(5):344–349. https://doi.org/10.1016/j.clbc.2013.05.004
Nilsson C, Johansson I, Ahlin C, Thorstenson S, Amini RM, Holmqvist M, Bergkvist L, Hedenfalk I, Fjällskog ML (2013) Molecular subtyping of male breast cancer using alternative definitions and its prognostic impact. Acta Oncol 52(1):102–109. https://doi.org/10.3109/0284186X.2012.711952
Yu XF, Feng WL, Miao LL, Chen B, Yang HJ (2013) The prognostic significance of molecular subtype for male breast cancer: a 10-year retrospective study. Breast 22(5):824–827. https://doi.org/10.1016/j.breast.2013.02.005
Arslan UY, Oksüzoğlu B, Ozdemir N, Aksoy S, Alkış N, Gök A, Kaplan MA, Gümüş M, Berk V, Uncu D, Baykara M, Colak D, Uyetürk U, Türker I, Işıkdoğan A (2012) Outcome of non-metastatic male breast cancer: 118 patients. Med Oncol 29(2):554–560. https://doi.org/10.1007/s12032-011-9978-9
Dabakuyo TS, Dialla O, Gentil J, Poillot ML, Roignot P, Cuisenier J, Arveux P (2012) Breast cancer in men in Cote d’Or (France): epidemiological characteristics, treatments and prognostic factors. Eur J Cancer Care (Engl) 21(6):809–816. https://doi.org/10.1111/j.1365-2354.2012.01365.x
Müller AC, Gani C, Rehm HM, Eckert F, Bamberg M, Hehr T, Weinmann M (2012) Are there biologic differences between male and female breast cancer explaining inferior outcome of men despite equal stage and treatment?! Strahlenther Onkol 188(9):782–787. https://doi.org/10.1007/s00066-012-0118-z
Yu E, Suzuki H, Younus J, Elfiki T, Stitt L, Yau G, Vujovic O, Perera F, Lock M, Tai P (2012) The impact of post-mastectomy radiation therapy on male breast cancer patients—a case series. Int J Radiat Oncol Biol Phys 82(2):696–700. https://doi.org/10.1016/j.ijrobp.2011.01.010
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Li, C., Li, X. Case Series Analysis of Male Breast Cancer. Indian J Surg 85, 764–770 (2023). https://doi.org/10.1007/s12262-022-03559-1
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DOI: https://doi.org/10.1007/s12262-022-03559-1