Abstract
The aim of the present study was to assess the activity of the hazelnut oil in the treatment of polycystic ovary syndrome in rats. Serum follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, testosterone, serum lipid parameters, leptin and glucose levels were evaluated. Moreover, antioxidant activity was tested using superoxide dismutase, malondialdehyde, catalase, glutathione peroxidase levels. The phytosterol content of the oil was determined by HPLC. The plasma high density lipoprotein-cholesterol level was found to be significantly high and leptin and glucose concentrations were found to be significantly low in the treatment group. According to the phytochemical analysis, the main components of the oil were detected as α-tocopherol, λ-tocopherol, squalene, β-sitosterol, campes-terol and stigmasterol. Corylus avellana oil was found to be effective in the treatment of polycystic ovary syndrome via regulating gonadotropins, steroids and serum lipid parameters and possesses antioxidant activity.
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Acknowledgement
Authors would like to thank Ferat ŞAHİN from Turkish Medicines and Medical Devices Agency, Ankara, Turkey, for his valuable help during HPLC analysis.
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MAD contributed to the laboratory works, analysis of the data. MI contributed to laboratory work, data analysis and collection of plant samples. IS contributed to manuscript writing, laboratory works and collection of plant samples. HK helped in histopathological studies. EKA designed the study, supervised the laboratory works, manuscript writing, helped in collection of plant samples.
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Demirel, M.A., Ilhan, M., Suntar, I. et al. Activity of Corylus avellana seed oil in letrozole-induced polycystic ovary syndrome model in rats. Rev. Bras. Farmacogn. 26, 83–88 (2016). https://doi.org/10.1016/j.bjp.2015.09.009
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DOI: https://doi.org/10.1016/j.bjp.2015.09.009