Abstract
Eleven compounds, 12-oxo-phytodienoic acid (1), persicogenin (2), eriodictyol 3′, 4′, 7-trimethyl ether (3), phytol (4), spathulenol (5), 4-hydroxycinnamic acid (6), onopordin (7), 5, 8, 4′-trihydroxy-7, 3′-dimethoxyflavone (8), quercetin (9), jaceosidin (10), and 8-hydroxyluteolin (11), were isolated from an ethanol extract of Lantana balansae Briq., Verbenaceae, that was found to possess antileishmanial activity. The structures of the compounds were determined by NMR spectroscopy and HR mass spectrometry, and 1, 2, 3, 7, 8 and 9 were investigated for antiprotozoal activity toward promastigotes of Leishmania amazonensis and Leishmania braziliensis. Compound 1 was shown to be the most potent, with the IC50 values 2.0 μM toward L. amazonensis and 0.68 μM toward L. braziliensis, although less potent than the positive control Amphotericin B. All compounds have been reported previously, but this is the first report of the isolation of a cyclopentenone fatty acid (1) and flavanones (2 and 3) from a Lantana species.
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Acknowledgments
The financial support of the Swedish International Development Agency (SIDA) in a frame of collaboration agreement between Lund University (Sweden) and San Simón University (Bolivia) is gratefully acknowledged. We thank to Lic. Modesto Zárate for identifiying the plant.
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EMM have contributed to plant collection, carried out the laboratory work, analysis of the NMR data and wrote the manuscript. ES and AG performed the biological studies. OS supervised the laboratory work, interpreted the NMR data and wrote the manuscript. All the authors have read the final manuscript and approved the submission.
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Maldonado, E.M., Salamanca, E., Giménez, A. et al. Antileishmanial metabolites from Lantana balansae. Revista Brasileira de Farmacognosia 26, 180–183 (2016). https://doi.org/10.1016/j.bjp.2015.11.007
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DOI: https://doi.org/10.1016/j.bjp.2015.11.007