Abstract
Diabetes mellitus is a chronic and severe metabolic dysfunction, it’s slow and progressive evolution interferes directly in the metabolism of carbohydrates, fats and proteins, causing hyperglycemia, glycosuria, polydipsia, hyperlipidaemia, among others. The aim of this study was to evaluate the antidiabetic effect of hydroethanolic extract and granulated of Calophyllum brasiliense Cambess., Clusiaceae, species in diabetic rats as well as it’s biochemical parameters. The results demonstrated that both the pharmaceutical forms, hydroethanolic extract and granulated, were able to reduce significantly (p < 0.001) hyperglycemia and glycosuria, in addition to improve polydipsia, polyuria, and weight loss. Treatments using hydroethanolic extract and granulated were also able to reduce significantly levels of triacylglycerides, cholesterol and low-density lipoprotein, as well as the transaminases, urea and creatinine levels. Therefore, it is concluded that these pharmaceutical forms have anti-diabetic effect and act improving the biochemical parameters, this effect is probably due to the high content of polyphenolic compounds found in the formulations.
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HOC, BSFS, IVFS, and HK contributed to the preparation of formulations and execution of experimental tests. HOC, RLR, CPF and JCTC, contributed execution of experimental tests and to development and critical reading of the manuscript. All authors read and approved the final manuscript submission.
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de Carvalho, H.O., e Souza, B.S.F., dos Santos, I.V.F. et al. Hypoglycemic effect of formulation containing hydroethanolic extract of Calophyllum brasiliense in diabetic rats induced by streptozotocin. Rev. Bras. Farmacogn. 26, 634–639 (2016). https://doi.org/10.1016/j.bjp.2016.04.004
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DOI: https://doi.org/10.1016/j.bjp.2016.04.004