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Table 1 Characteristics of patients with gout experiencing a cardiovascular event, Denmark, 1996–2020

From: Cardiovascular safety of using non-steroidal anti-inflammatory drugs for gout: a Danish nationwide case-crossover study

Characteristics

Number (%)

Total

59,150 (100)

Male sex

40,443 (68)

Age in years, median (interquartile range)

72 (62–79)

 ≤ 65

19,260 (33)

 65–74

16,859 (29)

 ≥ 75

23,031 (39)

Comorbidity burden†

 

 None (score: 0)

16,925 (29)

 Low (score: 1–3)

16,814 (28)

 Moderate (score: 4–5)

9,550 (16)

 Severe (score: ≥ 6)

15,861 (27)

Comorbidities

 Myocardial infarction

5,188 (8.8)

 Ischemic stroke

1,916 (3.2)

 Venous thromboembolism

1,602 (2.7)

 Chronic kidney disease

5,439 (9.2)

 Diabetes

9,619 (16)

 Chronic pulmonary disease

8,950 (15)

 Hypertension

22,902 (38)

 Obesity

2,936 (5.0)

 Hyperthyroidism

894 (1.5)

 Inflammatory rheumatic disease

11,526 (19)

 Degenerative rheumatic disease

10,575 (18)

 Soft tissue disorders

3,626 (6.1)

 Osteoporosis

1,289 (2.2)

 Headache

220 (0.37)

 Alcoholism

1,026 (1.7)

 Diseases of the liver

732 (1.2)

Comedication

 Acetylcholinesterase inhibitors

13,593 (23)

 Angiotensin II receptor blockers

4,876 (8.2)

 Beta-blockers

18,721 (32)

 Calcium channel blockers

10,497 (18)

 Diuretics

30,893 (52)

 Nitrates

6,006 (10)

 Statins

12,615 (21)

 Anti-coagulants

9,226 (16)

 Anti-platelets

17,186 (29)

 Selective serotonin reuptake inhibitors

2,707 (4.6)

 Systemic glucocorticoids

5,140 (8.7)

Type of gout

 Cancer related‡

5,290 (8.9)

 Not cancer related

53,860 (91)

  1. Cardiovascular event is defined as composite of myocardial infarction, ischemic stroke, congestive heart failure, atrial fibrillation/ flutter, and cardiovascular death
  2. Defined according to the Danish Comorbidity Index for Acute Myocardial Infarction (DANCAMI)
  3. Defined by the Anatomical Therapeutic Chemical Classification (see Supplementary Table S1) or the primary, in-/outpatient International Classification of Diseases 10th edition code DC (cancers) in the five years before gout