Abstract
The electrical activity of a network of mammalian neurons is mapped with a Multi-Transistor Array (MTA) fabricated with extended CMOS technology. The spatial resolution is 7.4 μm on an area of 1 mm2 at a sampling frequency of 6 kHz for a complete readout of 16,384 sensor transistors. Action potentials give rise to extracellular voltages with amplitudes in a range of 500 μV. On the basis of the high resolution in space and time, correlation algorithms are used to identify single action potentials with amplitudes as low as about 200μV, and to assign the signals to the activity of individual neurons even in a dense network.
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Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License (https://creativecommons.org/licenses/by-nc/2.0), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
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Lambacher, A., Vitzthum, V., Zeitler, R. et al. Identifying firing mammalian neurons in networks with high-resolution multi-transistor array (MTA). Appl. Phys. A 102, 1–11 (2011). https://doi.org/10.1007/s00339-010-6046-9
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DOI: https://doi.org/10.1007/s00339-010-6046-9