Fig. 3

Annexin A11 pathology in ALS due to ANXA11 p.G38R. a Annexin A11 positive inclusions were moderate to severe in amount, comprised of NCIs in the motor cortex (scale bar = 100 µm), hippocampus and striatum (scale bar = 50 µm), with rare skein-like spinal motor neuron inclusions (scale bar = 10 µm). b By double immunofluorescence, annexin A11 pathology was typically ubiquitin positive (scale bar = 20 µm). c Many annexin A11 aggregates appeared to be TDP-43 positive such as NCIs in the dentate gryus (upper row, scale bar = 20 µm). Rare annexin A11 positive spinal motor neuron inclusions were observed that were TDP-43 positive (middle row, scale bar = 10 µm), but many spinal motor neuron inclusions were TDP-43 positive and annexin A11 negative (lower row, scale bar = 20 µm)