Abstract
Purpose
Exercise-induced laryngeal obstruction (EILO) is relatively common in young people. Treatment rests on poor evidence; however, inspiratory muscle training (IMT) has been proposed a promising strategy. We aimed to assess laryngeal outcomes shortly after IMT, and to compare self-reported symptoms with a control group 4–6 years later.
Methods
Two groups were retrospectively identified from the EILO-register at Haukeland University Hospital, Norway; one group had received only information and breathing advice (IBA), and another additionally IMT (IBA + IMT). At diagnosis, all participants performed continuous laryngoscopy during exercise (CLE), with findings split by glottic and supraglottic scores, and completed a questionnaire mapping exercise-related symptoms. After 2–4 weeks, the IBA + IMT-group was re-evaluated with CLE-test. After 4–6 years, both groups were re-assessed with a questionnaire.
Results
We identified 116 eligible patients from the EILO-register. Response rates after 4–6 years were 23/58 (40%) and 32/58 (55%) in the IBA and IBA + IMT-group, respectively. At diagnosis, both groups rated symptoms similarly, but laryngeal scores were higher in the IBA + IMT-group (P = 0.003). After 2–4 weeks, 23/32 in the IBA + IMT-group reported symptom improvements, associated with a decrease of mainly glottic scores (1.7–0.3; P < 0.001), contrasting unchanged scores in the 9/32 without symptom improvements. After 4–6 years, exercise-related symptoms and activity levels had decreased to similar levels in both groups, with no added benefit from IMT; however, full symptom resolution was reported by only 8/55 participants.
Conclusion
Self-reported EILO symptoms had improved after 4–6 years, irrespective of initial treatment. Full symptom resolution was rare, suggesting individual follow-up should be offered.
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Introduction
Exercise-induced laryngeal obstruction (EILO) is an umbrella term describing inappropriate and transient adduction of laryngeal structures during exercise causing breathlessness and/or stridor [1], and is reported to affect 5–7% of young people [2, 3]. Symptoms typically peak at maximal exercise or immediately after, with respiratory distress, prolonged inspiration, a chocking sensation, and sometimes panic [4]. Symptoms of EILO are sometimes interpreted as exercise-induced asthma (EIA) [1, 5], a situation likely leading to mismanagement of both conditions [6]. Besides limiting otherwise healthy adolescents in their physical activities [6, 7], undiagnosed respiratory problems might reduce quality of life and disrupt participation on sports arenas [8, 9]. Individuals with EILO represent a diverse group and range from sedentary youngsters who might be affected in light activities, to top athletes whose performance is affected only when ventilation requirements are very high [10].
EILO is diagnosed by continuously visualizing the larynx with a flexible laryngoscope during maximal exercise (continuously laryngoscopy exercise test, CLE-test) [11]. Laryngeal obstruction can occur at the supraglottic or glottic level or involve both levels, and one may differentiate between EILO subgroups with mainly glottic or supraglottic obstruction, possibly associated with different causal mechanisms [12]. Laryngeal findings can be graded according to severity, using, e.g., CLE-scores, where higher scores indicate more obstruction [12, 13]. However, the perception of breathlessness is subjective [14, 15], and associations with CLE-scores are poorly described [16]. Treatment of EILO is largely based on empirical data [4, 12]. Most conservative strategies focus on making patients properly aware of their breathing pattern, structured breathing advice, and various breathing practices [1, 17,18,19]. Tailoring treatment modalities based on EILO subgroups or CLE-scores is still based on weak evidence, except for severe supraglottic EILO where supraglottoplasty has been reported successful [20].
Inspiratory muscle training (IMT) has been proposed a promising tool to treat EILO. Preliminary research suggest that IMT primarily improve the glottic component; however, randomized controlled studies are required to confirm these reports [22, 24-28]. IMT is based on breathing exercises performed with a resistance applied during inspiration, focusing on enhanced coordination and strengthening of the inspiratory muscles [21]. The effect might rest on the phasic relationship that exist between the diaphragm and the main laryngeal abductor (the posterior cricoarytenoid muscle); the former contracting immediately before the latter [23].
We aimed to assess improvements of self-reported symptoms and laryngeal outcomes in EILO shortly after treatment with standardized information and breathing advice (IBA) plus 6 weeks of IMT. After 4–6 years, we conducted a questionnaire-based follow-up in the same individuals, comparing their self-reported symptoms with a control group with EILO who had only received IBA.
Methods
The EILO-register and CLE-test
Since 2013, more than 99 percent of patients diagnosed with EILO at our institution have been consecutively enrolled in the Bergen EILO-register, where background demographics and self-reported questionnaires are stored together with data from the CLE-test, which contains laryngoscopy findings from rest to peak exercise, a soundtrack, and a film of the upper part of the body. CLE-tests are routinely performed as described previously [11], for details please see Fig. 1. The CLE-test permits grading of laryngeal obstruction from 0 (complete patency) to 3 (almost complete closure) at the glottic and supraglottic level (the CLE-score, see Fig. 2) [13]. The CLE recordings were rated in retrospect and in random order by two experienced reviewers who were both blinded to the identity of the person and the clinical situation (i.e., if the film was obtained at diagnosis or 2–4 weeks after IBA + IMT). The findings were split by supraglottic and glottic scores, and disagreements were solved by consensus.
Participants and study design
The participants were retrospectively identified from the Bergen EILO-register, based on access to a diagnostic CLE-test performed during 2013–2015, followed by treatment with standardized IBA plus 6-weeks of IMT, and a subsequent re-evaluation with CLE after 2–4 weeks (IBA + IMT-group). Only patients with a documented compliance to the IMT training exceeding 70%, assured by the memory card of the device, were included. A control group was identified, based on a diagnostic CLE-test and treatment with only IBA during 2013–2014 (IBA-group). A questionnaire mapping self-reported symptoms were completed by all participants at diagnosis and mailed to both groups at a follow-up 4–6 years later (Fig. 3).
The study was approved by the Committee on Medical Research Ethics of Western Norway (REK number 2016/1898). Informed written consent was obtained from participants and/or guardians.
Information and breathing advice (IBA) with biofeedback
Standardized IBA is provided by physicians as first line treatment to all patients diagnosed with EILO at our institution. IBA consists of information about the diagnosis, its benign nature and structured breathing advice while observing the laryngeal responses on the monitor (biofeedback). The breathing advice entails guidance in posture, relaxation of the shoulder girdle, diaphragmatic breathing, avoidance of noisy breathing/stridor during exercise, early recognition of initial signs of breathing problems, and regaining control when such signs arise. Patients are encouraged to maintain their level of physical activity, and to practice breathing advice while exercising.
After the IBA session, patients were (and still are) assigned to second-line treatment depending on the severity of the laryngeal obstruction and the motivation of the patient. At the time the participants were diagnosed, second-line treatment consisted of either speech therapy or inspiratory muscle training (IMT) for 6 weeks. As no hard data existed to prioritize between these two modalities, they were used interchangeably, based on availability. Only those enrolled in IMT treatment were relevant to this particular follow-up study.
Inspiratory muscle training (IMT)
Patients found eligible for IMT were recruited at time of diagnosis, after the IBA had been provided. IMT instructions were then given, and standardized training was performed over the following 6 weeks, using a resistive loading device, Respifit S® (Biegler GmbH, Mauerbach, Austria), for details please see Online resource 1, or a previous communication [27]. The protocol alternates between two modes of resistance; A) inspiratory resistance ≥ 80% of maximum produced mouth pressures (Pimax) [29], and B) inspiratory resistance: 60–80% of Pimax. Evaluation of IMT was performed 2–4 weeks after the 6-week training period with a second CLE-test.
Questionnaire
The participants (and/or guardians) completed a questionnaire at diagnosis, then 2–4 weeks after IMT (only the IBA + IMT-group), and at follow-up 4–6 years after diagnosis (all participants). The questionnaire (Online resource 2) covered medical history, development (Q–A.1–8) and significance (Q-B.1–2) of the breathing problem, symptom perception (Q1–18) and level of physical activity. A reminder was sent after 2 months to those who did not respond.
Study outcomes and statistical methods
This was a register-based descriptive follow-up study with self-reported symptoms as primary outcome, supplemented with CLE-scores obtained by a new CLE-test 2–4 weeks after treatment in the IBA + IMT-group. A secondary outcome was self-reported level of physical activity. CLE-scores are by nature categorical [13], but are reported as means with 95% confidence intervals (CI) which is considered to provide more information than medians and interquartile ranges when there are few categories [30]. Descriptive data was presented with counts and percentages. After checking for normality, the symptom scores (at diagnosis and follow-up) were compared with t-tests and one-way ANOVA, as appropriate. Mann–Whitney U test was applied for non-normally distributed data. Analyses were performed with SPSS version 24 (SPSS, Chicago, IL, USA). A P value < 0.05 was considered significant.
Results
Participants
Fifty-eight participants from the EILO-register were eligible for inclusion in the IBA + IMT-group, of whom 32/58 (55%) participants returned the questionnaire 4–6 years after diagnosis. Correspondingly, 58 participants, consecutively treated only with IBA, were approached as controls, of whom 23/58 (40%) participants returned the questionnaire (Fig. 3). The two groups had similar ratings of self-reported symptoms at diagnosis. Two participants in the IBA-group had to be excluded, as they had later been treated with supraglottoplasty. Demographics and symptoms at diagnosis did not differ between responders and non-responders (Online resource 3), except that non-responders in the IBA + IMT-group reported less problems when physically active (Q12). Mean (range) follow-up time was 59 (46–73) and 60 (54–71) months in the IBA and IBA + IMT-group, respectively. Demographic data are listed in Table 1. Although symptom scores were similar at diagnosis, CLE-scores were higher in the IBA + IMT-group (P = 0.003), which was as expected in a group selected for second-line therapy. Thirteen of the 32 IBA + IMT-group responders took part in a previously published study on IMT [27]. None reported any side effects at follow-up after training with IMT.
Re-evaluation, 2–4 weeks after IMT (IBA + IMT-group only)
Symptom scores had improved in most participants (23/32; 72%), and improvements were associated with reduced CLE-scores, particularly at the glottic level (P < 0.001). In participants without subjective improvement (9/32; 18%), the CLE-scores were unchanged (P.565) (Table 2, Fig. 4).
Follow-up 4–6 years after diagnosis (all participants):
The significance of the breathing problem and the severity of the symptoms
Most questionnaire items describing symptom severity had improved, with no differences between the two treatment groups (Table 3). There were no associations between a positive response at the re-evaluation 2–4 weeks after IBA + IMT treatment and symptom descriptions at the 4–6-year follow-up. Only five (16%) in the IBA + IMT-group and three (13%) in the IBA-group stated, “I no longer have a breathing problem” (Q–A.8). Seven (22%) in the IBA + IMT-group and 9 (39%) in the IBA-group stated, “the problem is unchanged and bothers me as much as before” (Q–A.2). One in the IBA + IMT-group reported worsening of the breathing problem (Q–A.1) (Table 4). In both groups, the impact of the breathing problem was reduced when “considering life overall” (Q-B.2), and the number responding positively to the question “I can control my symptoms when I get them” (Q18) was numerically increased; although significant only in the IBA + IMT-group (P 0.018) (Table 3).
Physical activity level at follow-up
Twenty-three (73%) in the IBA + IMT-group and 12 (52%) in the IBA-group reported reduced level of physical activity (P 0.803). Thirteen (41%) in the IBA + IMT-group and 10 (44%) in the IBA-group reported “less breathing problems because I am less active” (Q–A.4) (Table 4). Eight (25%) in the IBA + IMT-group and five (22%) in the IBA-group still reported “nearly always or always” to the question “I have breathing problems when I am physically active” (Q12). However, most participants in both the IBA + IMT (87%) and the IBA (65%) group answered “never” to the question “Symptoms prevent me from exercising” (Q14) (Table 3).
Individual differences at follow-up
There were extremes as regards self-reported symptoms at follow-up in both groups and in both directions; some reported to be symptom-free, and some reported still being severely affected. For example, in both treatment groups, responses at follow-up to the question “How much do your breathing problems effect you?” could vary from “not at all or a little” to “crippling” (Q-B.2). None in the IBA + IMT-group and two in the IBA-group reported panic (Q11) or to be afraid when symptoms arise (Q15).
Discussion
This is the first follow-up study aiming to evaluate self-reported symptoms and CLE-scores after IMT used to treat EILO. We found that self-reported symptoms and laryngeal findings had improved in most participants shortly after treatment with standardized IBA plus 6 weeks of IMT. Symptom improvement was associated with improved CLE-score, particularly at the glottic level. After 4–6 years, self-reported symptoms had improved to similar levels both in the IBA + IMT-group and in the IBA-group, irrespective of laryngeal findings and symptom reports shortly after the IMT. Symptom resolution was rare, and respiratory problems still disturbed most participants during exercise. The level of physical activity had decreased in most participants during the 4–6-year follow-up.
Strengths and limitations of the study
The major strengths of the study were enrolment of participants who were considered typical of patients seeking treatment for EILO, diagnostic accuracy ensured by a CLE-test performed in all participants at inclusion [1], and that a control group treated with IBA only were included for comparison at the 4–6-year follow-up. Recruitment was based on retrospective identification of all eligible participants from a nationwide EILO-register with high cover ratio. Major weaknesses were that information at the 4–6-year follow-up was based only on self-reports, the retrospective nature of the study and therefore a risk of recall bias, no randomization of participants between the two treatment groups, a high attrition rate, and relatively few participants. The lack of a control group at the time when the short-term influence of IMT was evaluated, prevents us from reliably ascribing the early changes in participants using IMT to the IMT itself—since IBA had also been provided. The questionnaire was not a validated instrument in relation to EILO, and relationships between answers therefore challenging to elucidate in some instances. However, key items were selected from sources validated in EILO or other respiratory contexts [31, 32]. Diagnostic characteristics from the time of the diagnosis were similar between responders and non-responders; however, we had no way of establishing their treatment motivation. The questionnaire required the participants to report utilization of other treatment modalities (for example psychological counselling) during the years that had passed since they had been diagnosed. Our response rate was in line with some [33] and lower than other studies [34,35,36], but the study still represents one of the few studies evaluating symptoms from EILO over time.
The challenges of self-reported symptoms and their relation to objective findings
Dyspnea is a complex and highly subjective feature [15], consisting of both a sensation of breathlessness and an emotional interpretation [37], i.e., the individual’s coping mechanisms to handle the breathlessness. As dyspnea can only be perceived by the individual who experience it, assessment must rest on self-report [38]. The questionnaire used in this study, addressed domains of sensory-perceptual experience and symptom impact or burden, as recommended when assessing dyspnea [38]. We know from other studies that self-reported instruments tend to overestimate intensity and duration of physical activity [39], and that poor physical condition often explain self-reported exercise-induced dyspnea [40], factors we could not control for in our study. Bias by recall or in terms of altered positive and negative expectations related to the experience of symptoms over time, may also be of importance. This mechanism may have been involved in the IBA + IMT-group, where the significance of the breathing problem was scored lower when asked at diagnosis, compared to when retrospectively confronted with the same question at follow-up (Table 3).
The study highlights numerous challenges relating to subjective symptom-reporting versus objective findings in general [41]. Specifically, the study underlines that individuals’ perception of dyspnea do not necessarily correspond to their CLE-scores. Symptom scores at diagnosis were similar in both groups, despite more advanced laryngeal obstruction (higher CLE-scores) in the IBA + IMT-group. Similar levels of self-reported symptoms at diagnosis facilitated a direct comparison at the 4–6 years follow-up, when symptom descriptions were still similar between the two groups, although at lower levels. Interestingly, at the CLE re-evaluation shortly after the IMT, subjective improvements of self-reported symptoms were associated with improved CLE-scores. However, this initial short-term response was seemingly unrelated to symptom scores 4–6 years later. A better understanding of the diagnostic implications and interactions between laryngeal obstruction and individuals’ perception of dyspnea is clearly an unmet need in this field of respiratory medicine [5, 16].
The age and gender distribution of EILO in this study and in general
Participants were recruited from the Bergen EILO-register, which has a high cover ratio, suggesting they were representative for typical EILO patients referred for second-line care. This notion is supported by an age distribution in line with most clinical EILO studies [2]. The participants of the IBA + IMT-group was slightly older than in the IBA-group, perhaps reflecting that older patients felt more motivated for second-line therapy. The female predominance was even higher than reported by others [2, 12], especially in the IBA + IMT-group. Although poorly investigated, gender-dependent anatomical changes of the larynx during puberty suggest a smaller inner diameter of the larynx in females that may explain a female predominance in young adults with EILO [42]. Females also tend to report higher symptom scores in health surveys [39], a factor that might contribute to more females considered for second-line therapy for EILO.
Development of EILO and physical activity
At follow-up 4–6 years after diagnosis, most participants had reduced their level of physical activity, and about half the participants reported that this was the cause of experiencing less breathing problems. The typical age for the debut of EILO corresponds to a period when physical activity often starts to decline [43, 44]. We do not know the natural course of EILO, but the few studies investigating this issue suggest that EILO persists over time [34,35,36]. This is consistent with our findings, with only a few participants reporting full resolution of their breathing problems. A study that re-examined individuals with EILO after 20 years of age, found that CLE-scores tended to be unchanged, paralleled by a decline of both physical activity and symptom severity [35]. These studies and our findings, indicate that a decline of self-reported respiratory symptoms in patients with EILO may be linked to a decline in the level of physical activity; i.e., not an improvement of the condition per se, but simply linked to a vanishing inducer (exercise) [24, 35, 36]. Given the relatively high prevalence of EILO, proper handling of these young individuals seems important also from a public health perspective, as it might contribute to maintenance of a healthy level of physical activity [43].
Information and breathing advice versus inspiratory muscle training
Several authors have suggested that IBA facilitates control of EILO symptoms [7, 19], and that IMT may have an added positive influence [27]. The present study might be used to support these views, as symptoms shortly after IBA + IMT had improved in a majority, and these improvements were associated with better CLE-scores. As already discussed, this must be tested in controlled studies, as short-term contributions from IBA and IMT cannot readily be distinguished in our study design. Moreover, the improvements of self-reported symptoms after 4–6 years contribute to a positive view on both conservative treatment tools. We found no significant difference long-term between those who received only IBA and those receiving additionally 6 weeks of IMT. The IBA and IMT incorporates some of the work which in other countries might have been provided by speech and language therapists, but was provided by physicians during only one session and at rest. We were not present when participants attempted to “translate” this experience into real-life exercise at home, aspects that may have hampered long-term effects [5]. We know for example, that muscle strength is reversible and changes over time [21]. One may speculate that repeated training sessions would contribute to maintenance of the positive short-term results obtained after IBA + IMT as reported when applied in patients with paradoxical vocal fold motion at rest [45]. This should be investigated in future controlled studies.
EILO subgroups and implications for choice of treatment
Tailored treatment based on laryngeal findings still rests on weak evidence, except in severe supraglottic EILO where laser surgery has been reported successful [20]. Subjective improvement shortly after IBA + IMT was associated with better CLE-scores, particularly at the glottic level, a finding substantiating the hypothesis that IBA + IMT mainly targets glottic obstruction [27]. Thus, it is reasonable to assume from this and previous studies that some EILO subgroups may not benefit from IBA + IMT. Indeed, a case-report suggests that IMT might even be counterproductive in severe supraglottic EILO [26]. A somewhat disappointing finding was that CLE-scores at diagnosis were not associated with self-reported symptoms 2–4 weeks after IBA + IMT, nor at follow-up 4–6 years later. Thus, diagnostic CLE-scores seemingly do not predict who will respond to IBA + IMT.
Conclusion
Self-reported symptoms and laryngeal findings had improved 2–4 weeks after treatment with IBA plus 6 weeks of IMT. After 4–6 years, self-reported symptoms were improved compared to at time of diagnosis; however, irrespective of initial treatment and findings 2–4 weeks after IBA + IMT. Full symptom resolution was rare, and respiratory problems still disturbed most participants during physical activity. Future studies should investigate if follow-up schemes after conservative treatment, including retraining sessions with IMT, will lead to strengthened and sustained improvements.
Abbreviations
- CI:
-
Confidence interval
- CLE test:
-
Continuous laryngoscopy exercise test
- EILO:
-
Exercise induced laryngeal obstruction
- IBA:
-
Information and breathing advice (instructed by a physician)
- IMT:
-
Inspiratory muscle training
- Pimax :
-
Maximal inspiratory mouth pressure
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Acknowledgements
The authors have no financial or non-financial interests that are directly or indirectly related to the work submitted for publication to disclose.
Funding
Open access funding provided by University of Bergen (incl Haukeland University Hospital). Research grant for Astrid Sandnes was received by Innlandet Hospital Trust, Norway. Research support in form of salaries to the authors and equipment was received by Haukeland University Hospital.
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All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by AS and in collaboration with the other authors. The first draft of the manuscript was written by AS and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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The authors have no conflicts of interest to disclose. Haukeland University Hospital owns parts of US patent No. 11/134551, protecting the commercial rights of the CLE test.
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The study was approved by the Regional Ethics Committee (REK number: 2016/1898), date 24 October 2018. The study was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. All participants provided informed written consent.
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Sandnes, A., Andersen, T., Clemm, H.H. et al. Clinical responses following inspiratory muscle training in exercise-induced laryngeal obstruction. Eur Arch Otorhinolaryngol 279, 2511–2522 (2022). https://doi.org/10.1007/s00405-021-07214-5
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Issue Date:
DOI: https://doi.org/10.1007/s00405-021-07214-5