Table 1 Overview of the number and type of genetic data used for prediction
Predicted phenotype | Study | Type of genetic variants used |
|---|---|---|
Breast cancer | Mealiffe et al. (2010) | 7 GWAS-SNPs with independent replication |
Wacholder et al. (2010) | 10 GWAS-SNPs | |
Dite et al. (2013) | 7 GWAS-SNPs with independent replication | |
Darabi et al. (2012) | 18 GWAS-SNPs | |
Vachon et al. (2015) | 76 GWAS-SNPs | |
Prostate cancer | Zheng et al. (2008) | 5 SNPs from candidate association studies |
Nam et al. (2009) | 19 SNPs from candidate association studies | |
Salinas et al. (2009) | 5 SNPs from GWAS/candidate studies showing independent cumulative association | |
Aly et al. (2011) | 35 GWAS-SNPs with independent replication | |
Johansson et al. (2012) | 33 GWAS-SNPS | |
Kader et al. (2012) | 33 GWAS-SNPs with independent replication | |
Klein et al. (2012) | 49 SNPs associated with prostate cancer or PS/1 SNP associated with breast cancer | |
Lindström et al. (2012) (five age groups) | 25 GWAS-SNPs | |
Helfand et al. (2013) | 4 SNPs from candidate association studies replicated in GWAS | |
Butoescu et al. (2014) | 9 GWAS-SNPSs | |
Esophageal squamous cell carcinoma (ESCC) | Chang et al. (2013) | 25 GWAS-SNPs |
Melanoma | Fang et al. (2013) | 11 GWAS-SNPs |
Cardiovascular disease (CVD) related events | Humphries et al. (2007) | 4 SNPs and 7 SNPs with interaction terms from candidate association studies |
Morrison et al. (2007) | 10 SNPs for whites and 11 SNPs for blacks from candidate association studies | |
Kathiresan et al. (2008) | 9 GWAS-SNPs (associated with LDL and HDL) | |
Paynter et al. (2009) | 1 SNP from a candidate association studies with independent replication | |
Davies et al. (2010) | 13 GWAS-SNPs | |
Paynter et al. (2010) | 101 GWAS-SNPs associated with CVD or an intermediate phenotype and 12 GWAS-SNPs associated with CVD but no intermediate phenotype | |
Ripatti et al. (2010) | 13 GWAS-SNPs | |
Brautbar et al. (2012) | 13 SNPs associated with CVD but no intermediate phenotype from GWAS/candidate studies with independent replication | |
Hernesniemi et al. (2012) | 24 GWAS-SNPs (associated with CAD) | |
Hughes et al. (2012) | 11 SNPs and 2 haplotype from GWAS with independent replication and 15 SNPs from GWAS with independent replication | |
Lluis-Ganella et al. (2012) (two cohorts) | 8 GWAS-SNPs associated with CVD but not with intermediate phenotypes | |
Bolton et al. (2013) | 27 SNPs from meta-analysis of GWAS-SNPs | |
Ganna et al. (2013) | 395 SNPs (associated with CHD and intermediate phenotypes) from GWAS and 46 SNPs (directly associated with CHD) from GWAS | |
Isaacs et al. (2013) | 95 SNPs from meta-GWAS on TC, LDL-C, HDL-C, and TG | |
Tikkanen et al. (2013) | 28 SNPs from GWAS | |
Ibrahim-Verbaas et al. (2014) | 324 GWAS-SNPs (associated with all stroke risk domains) | |
Beaney et al. (2015) | 13 GWAS-SNPs from CARDIoGRAMplusC4D and 19 SNPs from GWAS and candidate studies | |
de Vries et al. (2015) | 49 genome-wide significant SNPs and 103 SNPs at FDR <10 % | |
Atrial fibrillation | Everett et al. (2013) | 12 GWAS-SNPs |
Tada et al. (2014) | 12 GWAS-SNPs | |
Venous thrombosis | de Haan et al. (2012) | 5 SNPs from GWAS/candidate studies with independent replication |
Bruzelius et al. (2014) | 7 SNPs from GWAS and candidate association studies | |
Type 2 diabetes | Balkau et al. (2008) | 2 SNPs from candidate association studies |
Lyssenko et al. (2008) | 11 GWAS-SNPs | |
Meigs et al. (2008) | 18 GWAS-SNPs | |
van Hoek et al. (2008) | 18 GWAS-SNPs with independent replication | |
Lin et al. (2009) | 15 GWAS-SNPs | |
Schulze et al. (2009) | 20 GWAS-SNPs | |
Talmud et al. (2010) | 20 GWAS-SNPs with independent replication | |
Wang et al. (2010) | 19 SNPs from candidate studies with independent replication | |
de Miguel-Yanes et al. (2011) | 40 GWAS-SNPs | |
Vassy et al. (2012a) | 38 GWAS-SNPs | |
Vassy et al. (2012b) | 38 GWAS-SNPs | |
Mühlenbruch et al. (2013) | 42 GWAS-SNPs | |
Tam et al. (2013) | 14 GWAS-SNPs | |
Vassy et al. (2014) | 62 GWAS-SNPs | |
Walford et al. (2014) | 62 GWAS-SNPs | |
Parkinson disease | Hall et al. (2013) | 4 GWAS-SNPs |