Radiological predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis

Table 22 Mixed-effects single-variate meta-regression

The results of the meta-regression of the meta-analyses of Callosal angle (“CA), periventricular white matter (“PVM”) changes, disproportionately Enlarged Subarachnoid space Hydrocephalus (“DESH”) and cerebral blood flow (“CBF”), for each of the covariates (sample, year, age, females, HTN, Gait-, mRS, EI, CA, depression, S-R, Compl.) as independent variable to the dependent variable odds ratio. In round brackets is the standard error. If significance is yielded (denoted with * and bold regression coefficient), the p-value of the regression coefficient is shown in squared bracket only if significant, otherwise assume non-significance. A meta-regression was not performed for CT cisternography (“CTC”) due to small sample size (n = 3). Significance is assumed for p < 0.05. If a covariate was covered by < 3 studies for a respective radiological marker, then a regression analysis was omitted (“- “) for this respective relationship due to insufficient data for strong regression analysis. The different explanatory variables were calculated singularly as sole covariates in separate meta-regressions