Skip to main content
Account

Table 9 The use of ventricular size excluding Evan’s Index for prediction of shunt response in iNPH

From: Radiological predictors of shunt response in the diagnosis and treatment of idiopathic normal pressure hydrocephalus: a systematic review and meta-analysis

Study

Sample size

Radiological methodology

Cutoff specification

Image specification

Image plane

Main reported outcomes

Black [5]

n = 62

•Ventricular span

• > 55 mm

•Pneumoencephalogram (PEG)

•N/A

•There was no significant difference in those with spans over or under 55 mm between SR and SNR. Sensitivity: 90%, specificity 44.4%, PPV 50%, NPV 88.9%. TP 10, TN 8, FP 10 FN 1

Poca et al. [46]

n = 43

•Ventricular score: composite of maximal bifrontal distance, distance between the caudate nuclei at the level of the foramen of Monro, maximal width of the third ventricle, minimal width of both cella media, maximal inner diameter of the skull at the level of the measurement of the maximal bifrontal distance

•N/A

•CT

•N/A

•There was a positive correlation between score and % change on the Digit Span Forward attention test (rho = 0.46, p = 0.002)

Agerskov et al. [2]

n = 168

•Widest diameter of 3rd ventricle between anterior and posterior commissures

•Widest AP diameter of 4th ventricle

•N/A

•MRI 1.5 T.T1-weighted images

•3rd ventricle: coronal slice

•4th ventricle le: Sagittal

•There was no significant difference in 3rd or 4th ventricle size between SR and SNR

•3rd ventricle size: SR: 15.4 mm SNR: 16.5 mm

•4th ventricle: SR: 14.7 mm, SNR: 14.6 mm

Virhammar et al. [60]

n = 108

•Maximum 3rd ventricle diameter in widest part of inferior-superior direction

•N/A

•T1-weighted MRI. (9% of patients on 3 T scanner; 70% on a 1.5 T scanner, 14% on a 1 T scanner and 7% on a 0.5 T scanner

•Transverse plane in center of 3rd ventricle in AP direction

OR between SR and SNR: 1.24 (0.78–1.97), p = 0.37) was statistically insignificant

  1. Studies included assessing the use of any advanced imaging radiological marker as predictor of shunt responsiveness. SR, shunt response; S-NR, shunt non-response; PEG, pneumoencephalogram; NPV, negative predictive value; PPV, positive predictive value; TP, true positives; FP, false positives; TG, true negatives; FN, false negatives