Table 5 Distribution of patient response to treatment, in terms of reduction in number of days and hours with headache at each study time (i.e., T6, T12, and T18) with respect to baseline visit (47 patients)
Follow-up time | p values from HGLM and pairwise comparisons | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Outcome | Responder groups | T6 N (%) | T12 N (%) | T18 N (%) | Test for overall difference | T12–T6 | T18–T6 | T18–T12 | Test for trend |
Monthly days of headache | Non-responders: reduction <30% | 9 (19.1) | 4 (8.5) | 2 (4.3) | 0.078 | 0.195 | 0.114 | 0.344 | 0.025 |
Partial responders: reduction ≥30–<50% | 7 (15.0) | 5 (10.6) | 4 (8.5) | 0.570 | 0.655 | 0.655 | 0.655 | 0.294 | |
Responders: reduction ≥50–≤75% | 12 (25.5) | 22 (46.8) | 14 (29.8) | 0.024 | 0.047 | 0.638 | 0.107 | 0.667 | |
High responders: reduction >75% | 19 (40.4) | 16 (34.1) | 27 (57.4) | 0.012 | 0.389 | 0.140 | 0.009 | 0.069 | |
Monthly hours of headache | Non-responders reduction <30% | 7 (14.9) | 0 (0.0) | 0 (0.0) | <0.001 | 0.006 | 0.006 | 1.000 | 0.074 |
Partial-responders: Reduction ≥30–<50% | 2 (4.3) | 2 (4.3) | 0 (0.0) | 1.000 | 1.000 | 1.000 | 1.000 | 0.215 | |
Responders: Reduction ≥50–≤75% | 13 (27.6) | 9 (19.1) | 5 (10.6) | 0.122 | 0.266 | 0.121 | 0.266 | 0.038 | |
High responders: reduction >75% | 25 (53.2) | 36 (76.6) | 42 (89.4) | <0.001 | 0.009 | <0.001 | 0.051 | <0.001 | |