Fig. 4

Precision medicine profile and rational drug targeting of malignant melanoma. a Rewiring of metabolism and metabolic signaling affects melanogenesis and tunes central carbon metabolism to support evasion, proliferation, and survival of malignant melanoma. b Oncometabolites impact the epigenetic machinery by blocking or supplying carbons for histone modifiers. Epigenetic master regulators in cancer control transcriptional activation of other oncogenes or repression of tumor suppressors. c Personalized medicine strategies to overcome treatment resistance of malignant melanoma patients. d Patient profiles of The Cancer Genome Atlas (TCGA) reveal co-occurrence of BRAF and EZH2 hyperactivity making combination therapy of mitogen-activated kinase inhibitors (MAPKi) and epigenetic inhibitors (EPIi) viable. As alternative option, if immunotherapy (IMMUNOi) fails due to immune evasion and suppression of immune receptors, combination therapy of IMMUNOi and metabolic inhibitors (METABi) is sensible