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Table 5 Dose volume parameters of the rectal cancer patients

From: Excluding external iliac node irradiation during neoadjuvant radiotherapy decreases lower intestinal toxicity without compromising efficacy in T4b rectal cancer patients with tumours involving the anterior structures

 

EIN

NEIN

P value

Median (range)

Median (range)

GTV (cm3)

64.3 (18.9–245.3)

61.2 (22.0–418.9)

0.831

CTV (cm3)

521.9 (240.9–871.2)

411.0 (188.8–1077.1)

0.011

Small bowel

 Dmax (cGy)

5039 (2904–5345)

4779 (309–5392)

0.001

 V5 (cm3)

240.6 (14.1–531.8)

262.4 (0.0–696.20)

0.831

 V10 (cm3)

212.4 (1.8–497.6)

239.4 (0.0–611.7)

0.831

 V15 (cm3)

201.2 (0.1–460.0)

197.8 (0.0–585.2)

0.831

 V35 (cm3)

91.1 (0.0–276.2)

45.8 (0.0–196.3)

0.003

 V45 (cm3)

51.0 (0.0–130.0)

11.4 (0.0–116.6)

 < 0.001

Colon

 Dmax (cGy)

5194 (3039–5428)

4944 (2630–5419)

0.286

 V5 (cm3)

116.5 (40.0–462.9)

135.2 (26.2–830.7)

0.286

 V10 (cm3)

102.8 (19.7–418.4)

120.8 (24.4–694.6)

0.286

 V15 (cm3)

90.7 (17.6–411.7)

113.7 (20.8–645.5)

0.286

 V35 (cm3)

55.5 (0.0–257.9)

47.1 (0.0–239.2)

0.135

 V45 (cm3)

36.5 (0.0–109.0)

22.1 (0.0–219.7)

0.006

Bladder

 D30 (cGy)

4483 (2428–5145)

3752 (1296–5182)

 < 0.001

 D50 (cGy)

3938 (2161–4764)

3205 (1090–5143)

 < 0.001

 V45 (cm3)

29.0 (0–117.3)

11.8 (0.0–87.9)

0.001

  1. EIN, group with external iliac nodes radiation; NEIN, group without external iliac nodes radiation; GTV, gross tumour volume, including only the primary tumour volume; CTV, clinical target volume
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