The role and diagnostic value of deregulated miRNAs in cervical cancer

Parvizi, Masoumeh; Vaezi, Maryam; Jeddi, Farhad; Bakhshandeh, Masoumeh; Eghdam-Zamiri, Reza; Mobaraki-Asl, Noushin; Esmati, Ebrahim; Karimi, Abbas

doi:10.1007/s12672-025-02744-4

Table 3 List of the deregulated miRNAs in the body fluids of CC compared to the healthy individuals

From: The role and diagnostic value of deregulated miRNAs in cervical cancer

miRNAs	Body fluid	Methods	Up/Down-Regulated in CC ^a	References
miR‑125a‑5p	Plasma and exosomes	RNA-seq and qPCR	Down: CC < Normal	[143]
let-7 d-3p and miR-30 d-5p	Plasma and exosomes	RNA-seq and qPCR	Down: CIN I > CIN II⁺	[144]
miR-1468-5p	Serum and exosomes	qPCR	Up: CC > Normal	[145]
^a miR‑483‑5p, miR‑1246, miR‑1275 and miR‑1290	Serum	Array and qPCR	- Up: CC > Normal - miR-1290: CC > CIN > Normal	[146]
miR-20a and miR-203	Serum	qPCR	Up: CC > Normal UP: LNM (miR-20a) Down: LNM (miR-203)	[147]
miR-150	Serum	qPCR	Up: CC > Normal	[148]
miR-205	Serum	qPCR	Up: CC > Normal	[149]
miR-9, miR-10a, miR-20a and miR-196a	Serum	qPCR	Up: CIN > Normal Up: CIN-HPV⁺ > CIN-HPV⁻	[150]
miR-3142	Serum	qPCR	Up: Stage-II/III > Stage-I CC	[151]
miR-18a	Serum	qPCR	Up: Stage-III > Stage-I/II CC	[152]
miR-221	Serum	qPCR	Up: CC > Normal	[153]
miR-9, miR-192 and miR-205	Serum	qPCR	Up: CC > Precancer > Normal	[154]
miR-766-5p	Serum	qPCR	Up: CC > Normal	[155]
miR-152	Serum	qPCR	Up: CC > CIN (I/II) > CIN (III/IV) > normal	[156]
miR-21, −29a, −25, −200a and −486-5p	Serum	RNA-seq and qPCR	Up: CC > Normal	[157]
miR-1266	Serum	qPCR	Up: CC > HSIL > LSIL > Normal	[158]
miR-425-5p	Serum	qPCR	Up: CC > Benign CC > Normal	[159]
miR-G-1	Serum	qPCR	Up: CC > Normal	[63]
miR-497, miR-16–2*	Serum	qPCR	Up: CC > CIN and Normal	[160]
miR-34a and miR-218	Serum	qPCR	Up: LSIL > Normal	[161]
miR-29a, miR-25, and miR-486-5p	Serum	qPCR	Up: early-stage (I and II)	[43]
^b miR-20a, miR-205, miR-21, miR-29a, miR-200a, miR-25, and miR-486-5p vs miR-218	Serum	Machine learning	Up vs Down: early-stage (I and II)	[43]
miR-15b vs miR-34a and miR-218	Serum	qPCR	Up vs Down: (SCC vs Normal)	[161]
miR-21 vs 125b/miR-370	Serum	qPCR	Up vs Down: Normal and CIN compared to the early stage of CC	[162]
miR-17-5p/miR-32-5p/miR-454-3p vs miR-409-3p	Serum	RNA-seq and qPCR	Up vs Down: (CC vs Normal)	[163]
miR-21 vs miR-124	Serum	qPCR	Up vs Down: (CC vs Normal)	[164]
miR-21/miR-199a/miR-155-5p vs miR-34a/miR-145/miR-218	Serum and Urine	qPCR	Up vs Down: (CC vs Pre-cancer and Normal)	[98]
miR-100	Serum	qPCR	Down: (Normal and CIN > CC)	[165]
miR-195, miR-2861	Serum	qPCR	Down: CC < CIN and Normal	[160]
miR-1254	Serum	qPCR	Down: CC < Normal	[166]
miR-378a-3p	Serum	qPCR	Down: CC < Normal	[167]
miR-144-3p and miR-337- 3p	Serum	qPCR	Down: CC < Normal	[168]
miR-139-5p	Serum	qPCR	Down: CC < Normal	[169]
miR-375-3p	Serum	qPCR	Down: CC < Normal	[170]
miR-638, miR-521 and miR-203a-3p	Serum	qPCR	Down: Normal > CIN > CSCC	[171]
miR-1914-5p	Serum	qPCR	Down: CIN > CSCC	[171]
miR-29b	Serum	qPCR	Down: CC < Normal	[172]
miR-758	Serum	qPCR	Down: CC < Normal	[173]
miR-378a-3p	Serum	qPCR	Down: CC < Normal	[167]
miR-146a-5p, miR-151a-3p, miR-2110 and miR-21-5p	Plasma	qPCR	Up: CC > Normal	[174]
miR-432	Cervical mucus	qPCR	Down: Normal > CINII and CIN III > CC	[175]
miR-126-3p, −20b-5p, −451a, and −144-3p	Cervical mucus	Array and qPCR	Up: SCC and AD > Normal	[176]
miR-26b-5p, miR-142-3p, miR-143-3p, miR-191-5p, miR-223-3p and miR-338-3p	Cervical mucus	qPCR	Up: CIN3 > Normal	[177]
miR-92a-5p and miR-155-5p	Pap smear	qPCR	Up: LSIL and HSIL > Normal	[178]

^amiR-1290 expression escalates with CC progression, serving as an indicator of disease advancement. Conversely, other miRNAs exhibit increased expression in CC relative to healthy individuals, but do not show a significant rise in expression in a CIN compared to normal tissue
^bThe"vs"symbol indicates a comparison between upregulated and downregulated miRNAs. For instance, miR-20a, miR-205, miR-21, miR-29a, miR-200a, miR-25, and miR-486-5p are upregulated in the early stages of CC, while miR-218 is downregulated during these stages (miR-20a, miR-205, miR-21, miR-29a, miR-200a, miR-25, and miR-486-5p vs miR-218)

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