Fig. 4
From: Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease
EV miR-17 family expression altered by stroke subtype. EV expression of hsa-miR-17-5p (a), hsa-miR-20b-5p (b), hsa-miR-27b-3p (c) and hsa-miR-93-5p (d) was profiled in all stroke patients (n = 139) of which there were large artery (n = 22), cardioembolic (n = 40), SVD (n = 37) and unclassified (n = 40). Expression was compared to that of control, non-stroke patients (n = 34). Change in miRNA expression was assessed at 48 h post-stroke by qRT-PCR and RQ calculated from ΔΔCt following normalisation to a spike housekeeper miRNA, cel-miR-39 and compared to non-stroke control patients. Data are presented as RQ ± RQmax/RQmin. Probability values were calculated using one-way-ANOVA with post hoc Dunnett’s test, *p < 0.05; **p < 0.01