Fig. 5
From: Altered Extracellular Vesicle MicroRNA Expression in Ischemic Stroke and Small Vessel Disease
MiR-17 family miRNAs and targets. a Schematic representing three polycistronic miRNA clusters: miR-17-92, miR-106a-363 and miR-106b-25. The miRNAs in each cluster have been colour coded to represent which miRNA family (grouped according to seed sequence) each miRNA belongs to. The full miRNA structures for miRNAs -17-5p, -93-5p and -20b-5p have been given and the seed sequence (nucleotides 2–7) for each highlighted. miRNA targets were primarily selected on the basis of their complementarity to the seed sequence of any miRNA. The number of predicted targets involved in apoptotic pathways (b), cellular response to stress and hypoxia pathways (c) and repair pathways, including neurogenesis and vasculogenesis (d) have been summarised for each miRNA in the miR-17 family in Venn diagram form. The list of gene targets summarises those targets that all 3 miRNAs have in common