Abstract
Six β-carboline alkaloids including three new ones, trifilines A-C (1–3) were isolated from Trigonostemon filipes, along with a new β-carboline alkaloid, trigonoine C (7) isolated from Trigonostemon lii. Their structures were elucidated by extensive spectroscopic techniques. Trifilines A (1) and B (2) showed weak anti-HIV-1 activity with EC50 values of 54.61 µg/mL and 9.75 µg/mL, along with TI (Therapeutic index) values of 1.52 and 1.42, respectively. This is the first time to report the chemical constituents of Trigonostemon filipes.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Kiu, H. S.; Huang, S. M.; Chang, Y. T. In Flora Reipublicae Popularis Sinicae; Wu, Z. Y., Ed.; Science Press: Beijing, 1996; Vol. 44, pp 162–169.
Li, S. F.; Di, Y. T.; Li, S. L.; Zhang, Y.; Yang, F. M.; Sun, Q. Y.; Simo, J. M.; He, H. P.; Hao, X. J. J. Nat. Prod.2011, 74, 464–469
Hu, X. J.; Wang, Y. H.; Kong, N. Y.; He, H. P.; Gao, S.; Liu, H. Y.; Ding, J.; Xie, H.; Di, Y. T.; Hao, X. J. Tetrahedron Lett.2009, 50, 2917–2919
Tan, C. J.; Di, Y. T.; Wang, Y. H.; Zhang, Y.; Si, Y. K.; Zhang, Q.; Gao, S.; Hu, X. J.; Fan, X.; Li, S. F.; Hao, X. J. Org. Lett.2010, 12, 2370–2373
Li, S. F.; Di, Y. T.; He, H. P.; Zhang, Y.; Wang, Y. H.; Yin, J. L.; Tan, C. J.; Li, S. L.; Hao, X. J. Tetrahedron Lett.2011, 52, 3186–3188
Li, S. F.; Zhang, Y.; Li, Y.; Li, X. R.; Kong, L. M.; Tan, C. J.; Li, S. L.; Di, Y. T.; He, H. P.; Hao, X. J. Bioorg. Med. Chem. Lett.2012, 22, 2296–2299.
Wu, F. E.; Koike, K.; Nikaido, T.; Sakamoto, T.; Ohmoto, T.; Ikeda, K. Chem. Pharm. Bull.1989, 37, 1808–1809
Hu, X. J.; Di, Y. T.; Wang, Y. H.; Kong, N. Y.; Gao, S.; Li, C. S.; Liu, H. Y.; He, H. P.; Ding, J.; Xie, H.; Hao, X. J. Planta Med.2009, 75, 1157–1161.
Jain, M. P.; Koul, S. K.; Dhar, K. L.; Atal, C. K. Phytochemistry1980, 19, 1880–1882.
Tokuhiro, W.; Kazuhiko, H.; Jun, S; Michiyo, O.; Noriko, T.; Harumi, H.; Keiko, T.; Kayo, Y.; Akihiro, O. Heterocycles1989, 29, 123–131.
Wang, J. H.; Tam, S. C.; Huang, H.; Ouyang, D. Y.; Wang, Y. Y.; Zheng, Y. T. Biochem. Biophys. Res. Commun.2004, 317, 965–971.
Author information
Authors and Affiliations
Corresponding authors
Additional information
This article is published with open access at Springerlink.com
Electronic supplementary material
Rights and permissions
Open Access This article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
About this article
Cite this article
Li, SF., Cheng, YY., Zhang, Y. et al. β-carboline alkaloids from Trigonostemon filipes and Trigonostemon lii. Nat. Prod. Bioprospect. 2, 126–129 (2012). https://doi.org/10.1007/s13659-012-0028-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s13659-012-0028-x