Fig. 1

Mean plasma concentration–time profiles for the cytochrome P450 (CYP) probe drugs and metabolites alone and in the presence of risankizumab 150 mg administered subcutaneously every 4 weeks for 12 weeks. Open symbols indicate CYP probe drugs and metabolites alone on day 1; closed symbols indicate CYP probe drugs and metabolites on day 98 after 12-weeks of treatment with risankizumab