Table 1 Characteristics of included studies
From: Economic Costs of Myasthenia Gravis: A Systematic Review
Author (year) | Setting | Design | Data source(s) | Type of data | Study period(s) | Patient population |
|---|---|---|---|---|---|---|
Chicaiza-Becerra et al. (2012) [9] | Colombia | Modelling study (CEA) | Published literature | Clinical and economic model input data | NR | Patients with MG not associated with thymoma (n and distribution of age and sex NR) |
Desai et al. (2020) [23] | The United States | Retrospective, observational cohort study | The NIS part of the HCUP | Claims data | 2007–2014 | 175 patients with takotsubo syndrome secondary to MG crisis (median age: 73 years; 80% female) |
Furlan et al. (2016) [10] | Canada | Retrospective, observational cohort study; modelling study (CMA) | RCT; the Toronto General Hospital (Ontario, Canada); local unit costs | RCT, hospital expense, and unit cost model input data | 2007–2010 | 38 adults with MG treated with IVIG (mean age: 60 years; 55% female) and 32 with PLEX (mean age: 58 years; 53% female) for exacerbation of moderate to severe MG |
Guptill et al. (2011) [11] | The United States | Retrospective, observational cohort study | The AHS disease management database | Claims data | 2008–2010 | 1288 children and adults with MG (mean age: 60 years; 59% female) |
Guptill et al. (2012) [12] | The United States | Retrospective, observational cohort study | The AHS disease management database | Claims data | 2009 | 113 children and adults with MG (mean age: 60 years; 59% female) |
Heatwole et al. (2011) [13] | The United States | Modelling study (CMA) | Published literature; national unit costs | Clinical and economic model input data | NR | Patients with MG crisis (n and distribution of age and sex NR) |
Lai and Tseng (2010) [14] | Taiwan | Retrospective, observational cohort study | The NHIRD | Claims data | 2000–2007 | 5211 children and adults with MG (distribution of age and sex NR) receiving therapeutic and surgical treatment |
Mandawat et al. (2010) [15] | The United States | Retrospective, observational cohort study | The NIS part of the HCUP | Claims data | 2000–2005 | 1606 patients hospitalized for MG or MG crisis treated with IVIG or PLEX (distribution of age and sex for each stratum reported in the article) |
Mouri et al. (2019) [16] | Japan | Retrospective, observational cohort study | The Japanese Diagnosis Procedure Combination database | Claims data | 2010–2016 | 795 adults with MG hospitalized to receive thymectomy under general anaesthesia also treated with sugammadex (mean age: 55 years; 54% female) or placebo (mean age: 54 years; 50% female) |
Narla et al. (2020) [24] | The United States | Retrospective, observational cohort study | The NIS part of the HCUP | Claims data | 2002–2012 | Patients with MG with pemphigus or pemphigoid (n and distribution of age and sex NR) |
Ogino et al. (2017) [17] | Japan | Retrospective, observational cohort study | The JMDC | Claims data | 2015–2016 | Patients with MG (n and distribution of age and sex NR) |
Omorodion et al. (2017) [18] | The United States | Retrospective, observational cohort study | The NIS part of the HCUP | Claims data | 2003–2013 | 6394 children and adults hospitalized for MG exacerbation and discharged alive (results stratified by age categories; 58% female) |
Schepelmann et al. (2010) [19] | Germany | Cross-sectional, observational study | Survey administrated to patients identified via specialized centres part of the German Network of Muscle Disorders; national unit costs | Self-reported data | 2005 | 41 adults with MG (mean age NR; 56% female) |
Sonkar et al. (2017) [20] | India | Prospective, observational cohort study | Tertiary care teaching hospital in India | Self-reported and hospital expense data | 2014–2016 | 66 children and adults with MG (median age 42 years; 41% female) receiving conventional therapy and surgery (thymectomy) |
Souayah et al. (2009) [21] | The United States | Retrospective, observational cohort study | The NIS part of the HCUP | Claims data | 2001–2002 | 994 patients with severe MG with a primary or secondary procedure code for continuous mechanical ventilation (mean age: 65 years; 53% female) |
Tiamkao et al. (2014) [22] | Thailand | Retrospective, observational cohort study | The National Health Security Office (Bangkok, Thailand) | Claims data | 2009–2010 | 936 adult patients with MG (mean age: 45 years; 72% female) |