Fig. 1
From: Resistin Modulates Low-Density Lipoprotein Cholesterol Uptake in Human Placental Explants via PCSK9
Resistin induces LDLR, PCSK9, and SREBP-2 expression. A LDLR expression significantly increased in HepG2 cells and placental explant. B PCSK9 and C SREBP-2 expression increased significantly in the three experimental models. A one-way ANOVA and Tukey post hoc test was performed for significance testing. Data are shown as mean ± SD of 5 independent experiments. a: vs. 0 ng/mL; b: vs. 0 and 10 ng/mL; c: vs. 50 and 100 ng/mL; d: vs. 0, 10 and 25 ng/mL, and e: vs. 0 and 25 ng/mL. *p < 0.05; **p < 0.01; ***p < 0.001