Fig. 8: The impact of subretinal drusenoid deposits (SDD) and eccentricity of test target on rod-mediated dark adaptation (RMDA).

A Rod-intercept time (RIT) is stratified by disease severity and subretinal drusenoid deposits (SDD) absence versus SDD presence in older normals, early age-related macular degeneration (AMD), and intermediate AMD eyes. Circles are data points from individual eyes. Box-and-whisker plots represent median and interquartile ranges. Early and intermediate AMD eyes with SDD present had longer RITs than eyes with SDD absent. Yet in these eyes, SDD absent eyes also exhibited delayed RMDA. SDD grading was based on near-infrared reflectance and also en face and B-scan multimodal imaging as discussed in [22]. AMD severity groups are assigned based on colour fundus photography grading (ARED 9-step). Used with permission from the Association for Research in Vision and Ophthalmology with article published here [22]. B Scatterplot showing RIT at 5° and 12° for each participant stratified by the Age-Related Eye Disease Studies (AREDS) 9-step system (normal ageing, early AMD, intermediate AMD). The identity line represents a hypothetical scenario in which RMDA at 5° and 12° are equal. The majority had longer RIT at 5° than at 12°. RIT for RMDA at 5° in intermediate AMD eyes is ≥9.5 min whereas RIT in many older normal and early AMD eyes is <9.5 min. Used with permission from the Association for Research in Vision and Ophthalmology through Creative Commons with article published here [100].