Skip to main content
Springer Nature Link
Account
Fig. 3: Prdm4 expression in adipose tissue (aP2-Prdm4) protect from obesity and fat expansion in HFD feeding. | Cell Death & Disease

Fig. 3: Prdm4 expression in adipose tissue (aP2-Prdm4) protect from obesity and fat expansion in HFD feeding.

From: PI3Ka-Akt1-mediated Prdm4 induction in adipose tissue increases energy expenditure, inhibits weight gain, and improves insulin resistance in diet-induced obese mice

Fig. 3: Prdm4 expression in adipose tissue (aP2-Prdm4) protect from obesity and fat expansion in HFD feeding.

a A schematic transgenic construct used to generate adipose tissue-specific Prdm4 transgenic mice. b Representative Prdm4 and actin expression in iWAT, eWAT, and BAT from male littermate of non-transgenic (NonTg) and two lines of aP2-Prdm4 transgenic (Tg#1 and Tg#2) mice. c Body weight gains of Prdm4 Tg and NonTg male mice. Male NonTg or Prdm4 Tg mice were fed with a low-fat diet (LFD, 10% fat) or high-fat diet (HFD, 60% fat) for 8 weeks. (HFD: n = 7 (NonTg), n = 7 (Tg); LFD: n = 6 (NonTg), n = 7 (Tg)). d Differences in epididymal fat (eWAT) and inguinal fat (iWAT) weight gains in NonTg and Prdm4 Tg male mice. e Adipocyte size of epididymal fat (eWAT) from Prdm4 Tg and NonTg HFD-fed male mice. f Body composition of mice after 8 weeks of HFD-fed NonTg and Prdm4 Tg male mice. Data represent mean ± s.e.m. and statistically significant differences between control NonTg and Prdm4 Tg mice were determined by Student’s t-test. *P < 0.05; **P < 0.005

Back to article page