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Fig. 7: Diabetes suppressed CSF1 expression in testes recovered by melatonin. | Cell Death & Disease

Fig. 7: Diabetes suppressed CSF1 expression in testes recovered by melatonin.

From: Melatonin attenuates detrimental effects of diabetes on the niche of mouse spermatogonial stem cells by maintaining Leydig cells

Fig. 7: Diabetes suppressed CSF1 expression in testes recovered by melatonin.

a CSF1 expression with Hoechst 33342 and their merges of testicular sections from mice under four different treatments in the short term (W2, 2 weeks) and long term (W8, 8 weeks) experiments. Scale bar, 200 μm. b ELISA of CSF1 in mice serum of the four different groups in W2 and W8 experiments. c RT-qPCR detected Csf1 expression in mice testicular tissue under the four different treatments in W2 and W8 experiments. d CSF1 expression level detected by western blot analysis in the four groups in W2 and W8. Histograms are the statistical result of Image J (V1.48d) gradation analysis for the western blot experiments. (The results are shown as the mean ± S.E.M of at least three mice (n = 3) and the statistical significance was expressed as follows: *p < 0.05; **p < 0.01). C control group, M normal group treated with MLT, D diabetic group, DM MLT-treated diabetic group

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