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Fig. 3: DTL-induced EMT and cell migration and invasion through FOXO1. | Cell Death & Disease

Fig. 3: DTL-induced EMT and cell migration and invasion through FOXO1.

From: Overexpression of DTL enhances cell motility and promotes tumor metastasis in cervical adenocarcinoma by inducing RAC1-JNK-FOXO1 axis

Fig. 3: DTL-induced EMT and cell migration and invasion through FOXO1.

A Heatmap showing the top 200 up- or downregulated genes affected by DTL overexpression. B Enriched pathways for the top 200 genes associated with DTL in RNA-Seq assay including “SAPK/JNK pathway.” C FOXO1 expression is positively correlated with DTL through the TCGA database. D Western blotting demonstrated that DTL overexpression increases FOXO1 protein levels. E, F FOXO1 siRNAs (E) or FOXO1 inhibitor (AS1842856) (F) reduces DTL-induced EMT. G, H Quantified data of transwell migration (G) or invasion (H) assay in SiHa and Caski cells. Error bars indicate the mean ± SD of three independent experiments. Student’s t-test; *P < 0.05, **P < 0.01, ***P < 0.001.

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