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Table 2 Adjusted results for ROR score continuous (10-point) according to treatment group, and unadjusted HR estimates of the treatment effect of CEF with CMF as reference according to Prosigna ROR scores and subtype.

From: The Prosigna 50-gene profile and responsiveness to adjuvant anthracycline-based chemotherapy in high-risk breast cancer patients

 

DR

TR

OS

HR

(95% CI)

Pinteraction

HR

(95% CI)

Pinteraction

HR

(95% CI)

Pinteraction

ROR score, continuous (10-point)

0.056

  

0.02

  

0.83

 CMF

1.20

1.09;1.33

 

1.18

1.07;1.30

 

1.07

0.98;1.16

 

 CEF

1.04

0.92;1.18

 

1.00

0.89;1.13

 

1.06

0.96;1.16

 
      

<10 yrs

1.13

1.03;1.25

0.43

       

1.07

0.96;1.19

 
      

≥10 yrs

0.92

0.79;1.07

0.41

       

1.01

0.85;1.20

 

Unadjusted treatment effect of CEF versus CMF

ROR score

  

0.16

  

0.10

  

0.50

≤51

1.01

0.59;1.73

 

1.04

0.64;1.68

 

1.05

0.71;1.54

 

52-71

0.78

0.53;1.15

 

0.72

0.50;1.05

 

0.96

0.70;1.31

 

≥72

0.54

0.36;0.80

 

0.53

0.36;0.78

 

0.78

0.55;1.10

 

Subtype

  

0.06

0.07a

  

0.01

0.07a

  

0.03

0.04a

Luminal A

1.61

0.77;3.35

 

1.70

0.90;3.23

 

1.62

0.97;2.71

 

Luminal B

1.09

0.54;2.19

 

1.03

0.54;1.97

 

1.41

0.80;2.47

 

Basal-like

0.68

0.42;1.08

 

0.60

0.38;0.94

 

0.86

0.61;1.21

 

Her2-enriched

0.57

0.40;0.83

 

0.56

0.39;0.81

 

0.72

0.52;0.99

 
  1. CMF cyclophosphamide, methotrexate and fluorouracil, CEF cyclophosphamide, epirubicin and fluorouracil, ROR risk of recurrence, TR time to recurrence, DR distant recurrence, OS overall survival, HR hazard ratio, 95% CI 95% confidence interval, Pinteraction, P derived from a Wald test for heterogeneity.
  2. aTest of interaction Her2-Enriched vs (Luminal A, Luminal B, Basal-like).