Table 2 Adjusted results for ROR score continuous (10-point) according to treatment group, and unadjusted HR estimates of the treatment effect of CEF with CMF as reference according to Prosigna ROR scores and subtype.
DR | TR | OS | |||||||
|---|---|---|---|---|---|---|---|---|---|
HR | (95% CI) | Pinteraction | HR | (95% CI) | Pinteraction | HR | (95% CI) | Pinteraction | |
ROR score, continuous (10-point) | 0.056 | 0.02 | 0.83 | ||||||
CMF | 1.20 | 1.09;1.33 | 1.18 | 1.07;1.30 | 1.07 | 0.98;1.16 | |||
CEF | 1.04 | 0.92;1.18 | 1.00 | 0.89;1.13 | 1.06 | 0.96;1.16 | |||
<10 yrs | 1.13 | 1.03;1.25 | 0.43 | ||||||
1.07 | 0.96;1.19 | ||||||||
≥10 yrs | 0.92 | 0.79;1.07 | 0.41 | ||||||
1.01 | 0.85;1.20 | ||||||||
Unadjusted treatment effect of CEF versus CMF | |||||||||
ROR score | 0.16 | 0.10 | 0.50 | ||||||
≤51 | 1.01 | 0.59;1.73 | 1.04 | 0.64;1.68 | 1.05 | 0.71;1.54 | |||
52-71 | 0.78 | 0.53;1.15 | 0.72 | 0.50;1.05 | 0.96 | 0.70;1.31 | |||
≥72 | 0.54 | 0.36;0.80 | 0.53 | 0.36;0.78 | 0.78 | 0.55;1.10 | |||
Subtype | 0.06 0.07a | 0.01 0.07a | 0.03 0.04a | ||||||
Luminal A | 1.61 | 0.77;3.35 | 1.70 | 0.90;3.23 | 1.62 | 0.97;2.71 | |||
Luminal B | 1.09 | 0.54;2.19 | 1.03 | 0.54;1.97 | 1.41 | 0.80;2.47 | |||
Basal-like | 0.68 | 0.42;1.08 | 0.60 | 0.38;0.94 | 0.86 | 0.61;1.21 | |||
Her2-enriched | 0.57 | 0.40;0.83 | 0.56 | 0.39;0.81 | 0.72 | 0.52;0.99 | |||