Table 3 Genotype frequencies of the SNPs and their associations with risk of breast cancer.
From: MMP8 and MMP9 gene polymorphisms were associated with breast cancer risk in a Chinese Han population
SNP | Model | Genotype | Case | Control | Without adjustment | With adjustment of age | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P | AIC | BIC | OR (95% CI) | P | AIC | BIC | |||||
rs11225394 | Codominant | C/C | 445 (78.5%) | 445 (77.5%) | 1 | 0.033* | 1580.9 | 1596 | 1 | 0.042* | 1576.2 | 1596.4 |
C/T | 110 (19.4%) | 126 (21.9%) | 0.87 (0.65–1.16) | 0.88 (0.66–1.17) | ||||||||
T/T | 12 (2.1%) | 3 (0.5%) | 4.00 (1.12–14.26) | 3.83 (1.07–13.71) | ||||||||
Dominant | C/C | 445 (78.5%) | 445 (77.5%) | 1 | 0.7 | 1585.6 | 1595.6 | 1 | 0.71 | 1580.4 | 1595.5 | |
C/T-T/T | 122 (21.5%) | 129 (22.5%) | 0.95 (0.71–1.25) | 0.95 (0.72–1.26) | ||||||||
Recessive | C/C-C/T | 555 (97.9%) | 571 (99.5%) | 1 | 0.015* | 1579.8 | 1589.8 | 1 | 0.019* | 1575 | 1590.1 | |
T/T | 12 (2.1%) | 3 (0.5%) | 4.12 (1.16–14.65) | 3.94 (1.10–14.07) | ||||||||
Log-additive | — | — | — | 1.03 (0.80–1.33) | 0.81 | 1585.7 | 1595.7 | 1.03 (0.80–1.33) | 0.81 | 1580.5 | 1595.6 | |
rs3787268 | Codominant | G/G | 253 (44.3%) | 216 (37.5%) | 1 | 0.058 | 1590.4 | 1605.5 | 1 | 0.043* | 1584.5 | 1604.7 |
A/G | 257 (45%) | 286 (49.6%) | 0.77 (0.60–0.98) | 0.76 (0.59–0.97) | ||||||||
A/A | 61 (10.7%) | 74 (12.8%) | 0.70 (0.48–1.03) | 0.69 (0.47–1.01) | ||||||||
Dominant | G/G | 253 (44.3%) | 216 (37.5%) | 1 | 0.019* | 1588.6 | 1598.6 | 1 | 0.014* | 1582.8 | 1597.9 | |
A/G-A/A | 318 (55.7%) | 360 (62.5%) | 0.75 (0.60–0.95) | 0.74 (0.59–0.94) | ||||||||
Recessive | G/G-A/G | 510 (89.3%) | 502 (87.2%) | 1 | 0.26 | 1592.8 | 1602.9 | 1 | 0.22 | 1587.3 | 1602.4 | |
A/A | 61 (10.7%) | 74 (12.8%) | 0.81 (0.57–1.16) | 0.80 (0.55–1.14) | ||||||||
Log-additive | — | — | — | 0.82 (0.68–0.97) | 0.022* | 1588.8 | 1598.9 | 0.81 (0.68–0.96) | 0.016* | 1583 | 1598.1 | |