Figure 3
From: Lymphatic outflow of cerebrospinal fluid is reduced in glioma
CSF circulation was blocked at the site of the basal cistern. (a) Representative MRI images of the cisterna magna at 15 min, 25 min, 35 min, 45 mins and 55 min after contrast agent infusion. (b) Plots of percent change in signal-to-noise ratio (SNR) at the cisterna magna. The analyzed ROI is shown in Fig. S2. n = 5 in each group. Two-way ANOVA with Sidak’s multiple comparisons test was performed. (c) Representative images of P40D680 tracer at the circle of Willis (basal cistern region) in normal and glioma-bearing mice. Scale bar: 2 mm. (d) Quantification of tracer signal at the basal cistern region. Data are the mean± SD. (e) Representative images of P40D680 tracer at the brain surface of the left dorsal hemisphere in normal and glioma-bearing mice (contralateral to the glioma site). Scale bar: 1 mm. (f) Quantification of tracer signal on the dorsal brain surface. Data are the mean± SD.