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Figure 2 | Scientific Reports

Figure 2

From: Rheumatoid arthritis patients display B-cell dysregulation already in the naïve repertoire consistent with defects in B-cell tolerance

Figure 2

In-depth B-cell phenotype in rheumatoid arthritis by mass cytometry. The figure shows results from mass cytometry analysis of purified peripheral B cells from seven ACPA− RA patients, nine ACPA+ RA patients and seven healthy controls with a 35-marker panel (Supplemental Table 3). Data was analyzed to evaluate cell count differences between tSNE identified cell clusters (A) tSNE visualization of clustering for comparing cell counts in ACPA− RA, ACPA+ RA, and controls. Identified cell clusters with significant or borderline significant ANOVA differences between the three groups, after adjusting for sex, age and sample processing date, are highlighted in (A) (i–iv) and presented in more detail in (B) showing relative expression of the different markers in the B-cell clusters and the normalized cell counts in the three groups. (C) tSNE visualization highlighting the immunoglobulin isotype expression levels. Cell counts were normalized in the analysis.

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