Figure 1

Performance evaluation for somatic SNV calling in the four DREAM WGS datasets. SNVs called by eight individual callers, NeuSomatic, the majority voting with four callers (LoFreq, MuSE, MuTect2 and Strelka) and seven callers (LoFreq, MuSE, MuTect2, SomaticSniper, Strelka, VarDict and VarScan) were compared to the high confidence call sets respectively. Precision, recall and F1 scores were calculated for all comparisons and depicted in (A) precision-recall plot (B) F1 plot.