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Figure 4 | Scientific Reports

Figure 4

From: Identification, heterologous production and bioactivity of lentinulin A and dendrothelin A, two natural variants of backbone N-methylated peptide macrocycle omphalotin A

Figure 4

LC–MS analysis of backbone N-methylated peptides extracted from mushrooms O. olearius, L. edodes and D. bispora. (A–C) Ion chromatograms depicting some of the peptides species produced by 28 days liquid cultures of the respective fungi. In case of O. olearius (A) and D. bispora (B), both backbone-N-methylated macrocyclic peptides (M + H+) and additionally oxidized macrocyclic peptides (M + nO + H)+ thereof were observed in the culture supernatant. In case of the L. edodes liquid culture (C), oxidized cyclic peptides were detected in the fungal mycelium. (M + 2HO + H)+ represents the linear form of the macrocyclic peptide. (D) Chemical structures of omphalotin A, lentinulin A and dendrothelin A. Residues different from omphalotin A are underlined. Backbone N-methylation is indicated by green circles.

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