Ageing influences detrusor contractions to prostaglandin, angiotensin, histamine and 5-HT (serotonin), independent to the Rho kinase and extracellular calcium pathways

Table 1 Comparison of responses to GPCR activation between juvenile and adult detrusor tissues.

Agonist (concentration)	Δ Tension (mN)		n	p-value
Agonist (concentration)	Juvenile	Adult	n	p-value
Carbachol (1 μM)	112.95 ± 12.75	128.18 ± 17.39	24	0.48
Histamine (100 μM)	15.35 ± 2.94	8.63 ± 1.27	22	0.04
5-HT (100 μM)	26.09 ± 4.53	44.82 ± 7.54	22	0.04
NKA (300 nM)	35.99 ± 6.65	52.32 ± 8.50	24	0.14
PGE2 (10 μM)	22.93 ± 1.81	31.15 ± 3.21	24	0.03
ATII (100 nM)	6.40 ± 1.25	10.52 ± 1.50	24	0.04

Data reported as mean ± SEM.
Bold font indicates statistical significance (p < 0.05, unpaired Student’s two-tailed t-test).