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Fig. 10 | Scientific Reports

Fig. 10

From: Dose dependent toxicity of streptozotocin inducing diabetic complications in male Sprague Dawley rats with metabolic biochemical histopathological effects

Fig. 10

Effect of different administration of STZ on the histopathological picture of the brain of male Sprague- Dawley rats. Normal control group (Fig. 10A) showed normal histopathological picture of the cerebral cortex. STZ GROUP 45 showed also normal structure of cerebral cortex formed of neuronal cells; typically have large pale nuclei with prominent nucleoli. The non-neuronal cells (glial) cells include oligodendrocytes, hyperchromatic round nuclei with abundant clear cytoplasm (Fig. 10B). While STZ 60 Showed paler more elongated nuclei with scant cytoplasm, dilated and congested blood vessels (Fig. 10C). (n): Neuron Cells, (o): Oligodendrocytes, (a): Astrocytes, (Red Arrows): blood vessels. (H&E 200×)

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