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Fig. 3: Frequency of mTOR mutations. | npj Precision Oncology

Fig. 3: Frequency of mTOR mutations.

From: Emergence of mTOR mutation as an acquired resistance mechanism to AKT inhibition, and subsequent response to mTORC1/2 inhibition

Fig. 3: Frequency of mTOR mutations.

A Interrogation of IPCT database in MDACC found that of 20,150 patients sequenced, 273 cases of mTOR mutation were identified; cbioportal was used to identify the frequency in other datasets, including Metastatic Solid Cancers (UMich, Nature 2017) and the MSK-IMPACT Clinical Sequencing Cohort (MSKCC, Nat Med 2017)46,47. B Lollipop plot showing the distribution of mTOR mutations, including the mTOR A1459D mutation, detected in this case46,47.

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