Figure 4

Inhibitory effect of imatinib mesylate on SCF-enhanced proliferation in pancreatic cancer cell lines. Cells were incubated without either SCF or imatinib mesylate (control, white columns), or with 10 ng/mL SCF (black columns), or with 10 ng/mL SCF and 5 μM imatinib mesylate (horizontal striped columns) for 72 hours and proliferation was measured by WST-1 assay. Statistical analysis was performed by one-way ANOVA with the SNK test. Bars indicate the SD, *, p < 0.05 compared with control; #, p < 0.01 compared with SCF 10 ng/mL.