Choline PET based dose-painting in prostate cancer - Modelling of dose effects

Table 7 TCP-increase for different sensitivities of PET, low whole prostate dose, different α/β values, calculated α and low γ50(CN + 2 definition)

α [Gy^-1]	α/β [Gy]	γ50	Det. rate PET [%]	Dose [Gy]	SIB [Gy]	Single dose [Gy]	TCP_conv [%]	TCP Increase [%]
0.03	1.5	1.4	81	74	90	2	80	13.2
0.03	1.5	1.4	64	74	90	2	80	10.3
0.04	3.1	1.4	81	74	90	2	80	12.6
0.04	3.1	1.4	64	74	90	2	80	9.8
0.06	8.3	1.4	81	74	90	2	80	11.6
0.06	8.3	1.4	64	74	90	2	80	9.0

Calculation of the TCP-increase after boosting choline PET positive regions within the prostate up to 90 Gy. α/β was set to either Fowler's/Wang's or Valdagni's value, α was analytically determined in order to achieve agreement between calculated TCD50 and TCD50 obtained by Cheung et al. γ50 was again taken from Cheung's data (CN + 2 definition).