Table 1 Relative expression of DNA repair and cell cycle proteins in MCF-7 monolayer and mammosphere populations
From: Senescence evasion by MCF-7 human breast tumor-initiating cells
Protein | Dose(Gy) | Normalized band intensity (n = 3) | P value | |
|---|---|---|---|---|
Monolayer | Mammosphere | |||
APE1 | 0 | 1.00 | 2.10 | 0.024 |
1 | 1.02 | 1.92 | 0.052 | |
10 | 1.07 | 1.84 | 0.017 | |
ATM | 0 | 1.00 | 1.99 | 0.018 |
1 | 1.13 | 2.23 | 0.011 | |
10 | 1.62 | 1.99 | 0.088 | |
p21 | 0 | 1.00 | 0.04 | 0.001 |
1 | 1.16 | 1.04 | 0.207 | |
10 | 1.17 | 1.11 | 0.310 | |
Chk1 | 0 | 1.00 | 2.17 | 0.003 |
1 | 1.03 | 2.06 | 0.018 | |
10 | 1.05 | 2.31 | 0.052 | |
phospho-Chk1 | 0 | 1.00 | 0.92 | 0.116 |
1 | 1.13 | 0.80 | 0.027 | |
10 | 1.08 | 0.85 | 0.006 | |
Chk2 | 0 | 1.00 | 2.39 | 0.001 |
1 | 0.92 | 2.46 | 0.001 | |
10 | 0.93 | 2.51 | 0.005 | |
phospho-Chk2 | 0 | 1.00 | 0.69 | 0.034 |
1 | 0.91 | 0.64 | 0.030 | |
10 | 0.84 | 0.91 | 0.180 | |