Table 4 Unadjusted and adjusteda odds ratio (OR) comparing estimated risks of each perinatal outcome at < 18, 18–23, 60–119, and ≥ 120 months interpregnancy intervals with estimated risks following 24–59 months intervals, stratified by maternal age at current delivery
Outcome | Interpregnancy Interval, OR (95% CI) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
< 18 months | 18–23 months | 24–59 months | 60–119 months | ≥ 120 months | ||||||||||||
Unadjusted | Adjusteda | p-valuea | Unadjusted | Adjusteda | p-valuea | Unadjusted | Adjusteda | p-valuea | Unadjusted | Adjusteda | p-valuea | |||||
Small-for-gestational age | ||||||||||||||||
All women | 0.70 (0.31–1.37) | 0.62 (0.28–1.28) | 0.250 | 1.10 (0.55–1.99) | 1.04 (0.53–1.93) | 0.910 | 1.0 | 1.02 (0.73–1.44) | 1.00 (0.69–1.43) | 0.986 | 1.97 (1.33–2.93) | 1.85 (1.11–3.05) | 0.018 | |||
Maternal age, years | ||||||||||||||||
≤ 29 | 0.83 (0.27–2.12) | 0.75 (0.24–1.98) | 0.582 | 1.22 (0.40–3.14) | 1.21 (0.39–3.14) | 0.712 | 1.0 | 3.17 (1.65–6.19) | 3.16 (1.62–6.30) | < 0.001 | / | / | / | |||
30–34 | 0.22 (0.01–1.01) | 0.22 ((0.01–1.03) | 0.139 | 1.23 (0.46–2.69) | 1.24 (0.47–2.75) | 0.625 | 1.0 | 0.86 (0.51–1.42) | 0.73 (0.43–1.23) | 0.241 | 3.29 (1.54–6.37) | 2.19 (1.13–4.89) | 0.044 | |||
≥ 35 | 2.64 (0.41–10.02) | 2.63 (0.40-10.27) | 0.220 | / | / | / | 1.0 | 0.69 (0.34–1.48) | 0.57 (0.28–1.24) | 0.136 | 1.71 (0.88–3.58) | 0.85 (0.40–1.93) | 0.688 | |||
Low birth weight at full term | ||||||||||||||||
All women | 1.07 (0.31–1.37) | 1.14 (0.62–1.93) | 0.658 | 0.97 (0.55–1.99) | 0.98 (0.50–1.74) | 0.945 | 1.0 | 1.11 (0.73–1.44) | 0.97 (0.71–1.34) | 0.829 | 1.93 (1.32–2.91) | 1.34 (0.85–2.11) | 0.208 | |||
Maternal age, years | ||||||||||||||||
≤ 29 | 1.40 (0.65–2.85) | 1.30 (0.59–2.74) | 0.496 | 1.50 (0.62–3.27) | 1.55 (0.64–3.42) | 0.300 | 1.0 | 1.25 (0.58–2.55) | 1.20 (0.55–2.50) | 0.630 | 8.18 (0.44–44.06) | 10.42 (0.55–59.52) | 0.030 | |||
30–34 | 0.57 (0.14–1.57) | 0.61 (0.15–1.67) | 0.404 | 0.35 (0.06–1.14) | 0.37 (0.54–1.37) | 0.165 | 1.0 | 0.87 (0.54–1.37) | 0.77 (0.47–1.24) | 0.280 | 1.12 (0.34–2.78) | 0.89 (0.26–2.31) | 0.824 | |||
≥ 35 | 0.96 (0.05–4.80) | 0.86 (0.05–4.39) | 0.888 | 1.48 (0.23–5.32) | 1.35 (0.21–4.94) | 0.697 | 1.0 | 1.18 (0.68–2.19) | 1.09 (0.62–2.02) | 0.784 | 1.80 (1.02–3.36) | 1.27 (0.67–2.50) | 0.478 | |||
Preterm birth | ||||||||||||||||
All women | 0.99 (0.79–1.22) | 0.98 (0.78–1.22) | 0.867 | 0.83 (0.64–1.05) | 0.82 (0.63–1.04) | 0.113 | 1.0 | 1.27 (1.14–1.43) | 1.28 (1.08–1.38) | 0.001 | 1.74 (1.50–2.01) | 1.52 (1.27–1.82) | < 0.001 | |||
Maternal age, years | ||||||||||||||||
≤ 29 | 0.77 (0.55–1.05) | 0.90 (0.64–1.24) | 0.523 | 0.69 (0.46-1.00) | 0.75 (0.50–1.10) | 0.156 | 1.0 | 1.67 (1.30–2.13) | 1.50 (1.16–1.93) | 0.002 | 1.96 (0.30–7.25) | 1.34 (0.20–5.31) | 0.709 | |||
30–34 | 1.16 (0.82–1.59) | 1.19 (0.84–1.64) | 0.314 | 0.93 (0.65–1.30) | 0.96 (0.67–1.34) | 0.806 | 1.0 | 1.35 (1.15–1.59) | 1.21 (1.02–1.43) | 0.029 | 2.93 (2.19–3.87) | 2.17 (1.59–2.92) | < 0.001 | |||
≥ 35 | 1.05 (0.43–2.17) | 1.01 (0.41–2.11) | 0.985 | 0.68 (0.26–1.45) | 0.65 (0.25–1.40) | 0.314 | 1.0 | 1.16 (0.92–1.48) | 1.06 (0.84–1.36) | 0.625 | 1.59 (1.25–2.04) | 1.17 (0.89–1.55) | 0.026 | |||
Adverse neonatal Composite* | ||||||||||||||||
All women | 0.68 (0.34–1.22) | 0.70 (0.35–1.26) | 0.265 | 0.70 (0.34–1.29) | 0,71 (0.34–1.30) | 0.300 | 1.0 | 1.19 (0.90–1.58) | 1.08 (0.80–1.45) | 0.631 | 1.33 (0.90–1.92) | 0.96 (0.60–1.51) | 0.852 | |||
Maternal age, years | ||||||||||||||||
≤ 29 | 0.38 (0.09–1.10) | 0.48 (0.11–1.42) | 0.237 | 0.74 (0.22–1.96) | 0.84 (0.24–2.24) | 0.753 | 1.0 | 2.17 (1.15–4.07) | 1.76 (0.92–3.35) | 0.085 | 8.18 (0.44–44.06) | 4.59 (0.24–27.31) | 0.165 | |||
30–34 | 1.14 (0.47–2.34) | 1.13 (0.46–2.37) | 0.758 | 0.90 (0.34–1.94) | 0.91 (0.35–1.97) | 0.827 | 1.0 | 1.17 (0.78–1.74) | 1.03 (0.68–1.56) | 0.873 | 2.41 (1.15–4.57) | 1.62 (0.74–3.21) | 0.194 | |||
≥ 35 | 0.75 0.04–3.69) | 0.68 (0.04–3.41) | 0.714 | / | / | / | 1.0 | 0.85 (0.51–1.50) | 0.77 (0.45–1.36) | 0.350 | 0.88 (0.49–1.62) | 0.58 (0.30–1.13) | 0.106 | |||