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Fig. 3 | Cancer Cell International

Fig. 3

From: Transcriptomics assisted by metabolomics analysis provides insights into regulation mechanisms during carcinogenic process in a hydrodynamically transfected liver cancer model

Fig. 3

Transcriptomic analysis revealed that differentially expressed genes (DEGs) were significantly enriched into cell cycles pathways. (A) Number of upregulated gene and downregulated ones between liver of experimental group and control; (B) Volcano plot of gene expression between liver of experimental group and control, Red: high expression, yellow: low expression; (C) Top 20 DEGs (|log2FC|> 1, p < 0.05) containing upregulated genes (red) and downregulated genes (blue) were visualized by hierarchical clustering based on gene expression difference (log2fold change, x axis) and statistical significance (− log10 p value, y axis); (D) KEGG enrichment analysis suggest that DEGs were significantly enriched into cell cycles pathways; (E) Analysis of TCGA data showed that expression of Top 20 DEGs was significantly increased in 371 hepatocellular carcinoma (LIHC) patients compared with 50 controls (P < 0.0001);

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