Fig. 9

Human PMSCs derived sEVs alleviate neuropathic pain through its anti-inflammatory effect. miR-26a-5p regulated Wnt5a/Ryk/CaMKII/NFAT, a non-canonical Wnt signaling, partly take part in the analgesia of hPMSCs derived sEVs through down-regulating the IL-1β, IL-6, and TNF-α