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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: High-affinity transferrin receptor binding improves brain delivery of bispecific antibodies at tracer dose

Fig. 3

Ex vivo autoradiography of three bispecific affinity variants and Bapi in WT and AppNL−G−F mice over 168 h post-injection. Autoradiography in sagittal sections from WT and AppNL−G−F mice injected with [125I]I-Bapi-8D3WT, [125I]I-Bapi-8D3Y32A, [125I]I-Bapi-8D3Y52A and [125I]I-Bapi at 4, 24, 72 and 168 h post-injection. The intensity for [125I]I-Bapi-8D3WT and [125I]I-Bapi-8D3Y32A are scaled differently than [125I]I-Bapi-8D3Y52A and [125I]I-Bapi

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