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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer

Fig. 7

CTBP2 was regulated by circHERC4/miR-556-5p interaction. a Representative image of the co-expression of circHERC4, miR-556-5p and CTBP2 in CRC tissues divided into high-grade group and low-grade group according to the clinical stage. b Representative images of subcutaneous xenograft tumors formed by SW480 cells stably transfected as indicated in nude mice. c, d Tumor weights (c) and tumor volumes (d) were measured for each group (n = 6 per group). *, P < 0.05, **, P < 0.01, ***, P < 0.001. e IHC staining of CTBP2, E-ca and Ki67 in each group. Overexpression of circHERC4 could upregulate CTBP2 and Ki67 and downregulate E-ca expression; the effect could be rescued by inhibiting of CTBP2 or overexpression of miR-556-5p. *, P < 0.05, **, P < 0.01, ***, P < 0.001. f Images and statistics of visible nodules on the lung and liver surface. g Representative images of HE staining analysis of metastatic nodules in lungs and livers. *, P < 0.05, **, P < 0.01, ***, P < 0.001

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