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Table 3 Multivariate Cox proportional hazards analysis a of RFS according to RARβ2 hypermethylation, stratified by histology, in never-smokers

From: RARβ2 hypermethylation is associated with poor recurrence-free survival in never-smokers with adenocarcinoma of the lung

 

RARβ2 hypermethylation

HR

95% CI

P value

A. Adenocarcinoma

No

1.00

  

  (N = 128)

Yes

2.19

1.28 to 3.47

0.009

B. Other cell types

No

1.00

  

  (N = 23)

Yes

3.27

0.71 to 16.23

0.16

  1. HR, hazard ratio; CI, confidence interval.
  2. aAdjusted for age, sex, differentiation, tumor size, pathologic stage, histology, adjuvant chemotherapy, and protein clusters [(β-catenin/E-cadherin), c-MET, and (cyclin D1/EGFR)].
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