Hippocampal atrophy but not white-matter changes predicts the long-term cognitive response to cholinesterase inhibitors in Alzheimer’s disease

Table 2 Regression coefficients in Cox proportional hazard models of factors associated with TMSE decline-free survival

Model		B	SE	Exp(B) (95 % CI)	P-value
Model I	Age of starting ChEI	−0.030	0.008	0.971 (0.955 ~ 0.986)	<0.0005
Model II	Age of starting ChEI	−0.035	0.008	0.965 (0.949 ~ 0.981)	<0.0005
Model II	Total MTA score	0.147	0.047	1.158 (1.056 ~ 1.271)	0.002

CDR Clinical Dementia Rating, ChEI cholinesterase inhibitor, MTA medial temporal atrophy, TMSE Taiwanese Mini-Mental State Examination, WMH white matter hyperintensity, CI confidence interval; excluded variables in Model II: gender, educational level, baseline TMSE, baseline CDR, and total WMH score; excluded variables in Model I: gender, educational level, baseline TMSE, baseline CDR, total WMH score, and total MTA score