Mitochondrial transfer in cancer: mechanisms, immune evasion, and therapeutic opportunities

Table 1 Proposed Therapeutic Target of TNT-mediated MT

Target to inhibit	Mechanism of Action	Related Inhibitor	Key References
RAC1	Blocks actin dynamics and TNT formation, Reduced mitochondrial transfer	NSC23766, EHT1864, ZINC69391	[109,110,111,112,113]
RHOT1 (Miro1)	Disrupts mitochondrial trafficking and TNT function, Impaired tumor adaptation to hypoxia, reduced cancer survival	Miro1 Reducer (CAS 2624336–91-8)	[25, 113, 114]
MTFR2	Limits mitochondrial fission and transfer, suppresses tumor growth	None	[39,40,41, 115, 116]
DRP1	Inhibits mitochondrial fission, reduces mitochondrial transfer	Mdivi-1, MIDI, P110, PPD1	[36, 117,118,119]