Abstract
The chapter will focus on fundamental aspects and methodological challenges of X-ray free electron laser research and recent developments in the related field of ultrafast X-ray science. Selected examples proving “molecular movie capabilities” of Free-electron laser radiation investigating gas phase chemistry, chemistry in liquids and transformations in the solid state will be introduced. They will be discussed in the context of ultrafast X-ray studies of complex biochemical research, and time-resolved X-ray characterisation of energy storage materials and energy bionics.
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1 Introduction
After a preparation phase of almost twenty years—from the first vision of a common research effort in synchrotron radiation in Europe (1975) up to the first electron beam entering the first high-brilliant, third generation X-ray synchrotron ring in 1992 (at the European Synchrotron Radiation Facility)—synchrotron radiation has proven its unique X-ray photons characteristics in brilliance, coherence, pulsed properties and high-repetition frequencies—allowing for the development of various synchrotron-typical experiments such as high-resolution X-ray crystallography and anomalous X-ray scattering, the various types of X-ray spectroscopy techniques, X-ray time-resolved methods and coherent and incoherent X-ray diffraction techniques (to name some examples). The techniques have been adapted for and applied to material research, chemistry, solid state and biophysics, earth and planetary research, astrophysics etc.
In the begin of the 2nd millennium, synchrotron researchers faced a similar situation as in begin of 1980s—again with a 20 years agenda from 2000 on—entering their next research “quantum step” by extending the novel technique of the so-called Free-Electron Laser (FEL) principle [1,2,3,4,5,6] from short arrangements of water-cooled magnets to very long arrangements of water-cooled (and now even superconducting) magnets [1,2,3,4,5,6]. Since in free-electron lasers high-speed electrons freely move in a magnetic field [1, 2], being accelerated and decelerated in the field, and by thus generating radiation, changing the properties of the magnetic fields as explained allow for moving from the FEL-generation of micro-waves [2, 4] to the ones of X-ray radiation [4,5,6]. Free-electron lasers are therefore fully tunable and they have the widest frequency range of any laser type .
By developing the FEL-principle to the hard X-ray regime [4,5,6,7]—a gap between the “traditional” synchrotron radiation world and the FEL radiation world has been closed—one of the reasons why FEL radiation is also sometimes called “synchrotrons of the 4th generation” (at least from the perspective of synchrotron researchers). As a consequence, the properties of the novel FEL sources and the properties of the produced X-ray radiation have been amplified by many orders of magnitudes compared to current synchrotron sources of the 3rd generation.
Milestones in the FEL development agenda were the first soft X-ray free-electron laser in operation—2005 the Free-Electron LASer FLASH at DESY in Hamburg, the first hard X-ray free-electron laser in operation—2009 the Linear Coherent Light Source LCLS at SLAC in Stanford (which is a so-called 1st generation of FELs based on a low-repetition frequency approach), and the first high-repetition frequency hard X-ray FEL in operation—2017 the European X-ray Free Electron Laser European XFEL at DESY and in Schenefeld. How these “quantum jumps” in X-ray properties can be made used for novel approaches of research in chemistry will be topic of this chapter.
In order to reflect milestones developments from 2006 on, the chapter reflects recent research summaries [8,9,10] as well as novel developments.
If one reads about chemical reactions and the measurement of real-time responses in chemical reactions, one very quickly ends up with the concept of the resolution of measurements on ultrafast time scales, which are characteristic for the movement of atoms in molecules, i.e. femtoseconds. A femtosecond is defined as the millionth of a billionth of a second. Life-relevant motions, however, can be as slow as seconds or even up to minutes’ or hours’ time scales. The origin of these time scale differences is based on the complexity of the coordination space of a proceeding reaction [8,9,10,11,12,13,14].
In a classical kinetic scheme, following the explanatory approach, the gradients on the potential energy hypersurface define the molecular dynamics. Statistically population-weighted, they compose to the kinetics of a chemical reaction. The coordinates describing the dynamics and kinetics of a chemical reaction are the reaction coordinate and the energy. The reaction coordinate is defined as a one-dimensional projection of the reactant’s and product’s normal coordinates, which span the potential energy hypersurface of reactant and product and the potential energy hypersurfaces of their transitions (Fig. 17.1). The energy gradient along a reaction coordinate is defined as reaction dynamics, the energy gradient along the normal coordinates as molecular dynamics.
Commonly, the potential energy is presented as the characteristic curve or hypersurface in the graph, and the ordinate axis presents the sum of the potential and kinetic energy of the nuclei involved in the chemical reaction (Fig. 17.2). Potential and kinetic energy of molecules can be detangled through the projection of the potential energy onto the total energy axis. The activated complex and transition state (according to Eyring) includes an imaginary vibrational mode [11,12,13,14, 16].
From a chemical physicist’s point of view, one would like to understand which elementary chemical processes happen at which time scales, and how these time scales are inter-connected. To what extend do structural motifs “freeze in” time and dynamics information of chemical reactions? Which type of apparatus needs to be built and which kind of methods need to be developed for investigating the created femtosecond “time stamps” in the structure of complex matter during a chemical or biochemical reaction?
Ultrafast X-ray methods bear the potential of determining the complexity of chemical reactions—during their reactions, in particular in the bulk, with techniques which utilize the specific characteristics of X-ray/matter interaction: in well-ordered systems, X-ray crystallography as a Thomson scattering process allows for element-specific determinations such as electron densities (redox states) and high-precision spatial resolution determination of atoms in lattices from which hydrogen bonding, chemical bonding or van der Waals stacks can be derived. In less-ordered and disordered systems, X-rays deliver element-specific information of the investigated molecules utilizing, for example, X-ray spectroscopy, X-ray absorption, photo-induced electron cascades, or X-ray and electron emission properties. Site-specific information is obtained by elastic and inelastic scattering processes such as multidimensional X-ray spectroscopy, X-ray diffraction, or X-ray scattering. The chemical consequences of X-ray/matter interactions leading to fragmentation can be characterized by X-ray mass spectrometry.
Characteristic for the X-ray photons generated in synchrotrons and free-electron lasers are their
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energy tunability (allowing for excitation-energy-sensitive methods like X-ray spectroscopy or advanced X-ray diffraction methods)
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pulsed structure (allowing for in-situ and time-resolved X-ray methods)
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defined polarization (allowing for advances in X-ray spectroscopy)
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coherence (allowing for X-ray imaging or correlation spectroscopy methods)
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high flux (allowing for high-resolution X-ray experiments in all experimental domains)
Fourth generation accelerator-based light sources (free-electron lasers, FELs) in the VUV or X-ray regime deliver ultra-brilliant coherent radiation in very short pulses (e12 to e13 photons/bunch/10–100 fs). In order to fully exploit their unique photon capabilities, novel instrumentation is required based on single-shot (collection) schemes. Moreover, hundreds up to trillions of fragment particles, ions, electrons or scattered photons can emerge when a single light flash impinges on matter with intensities up to (predicted for the XFEL) 1022 W cm\(^{-2}\). In order to meet these challenges, in the starting time of FLASH (Free-Electron Laser in Hamburg [16a]) and the LCLS (Linac Coherent Light Source [16b]), various experimental chambers and endstations have been designed. Further constructions, in particular for relevance for this chapter have been developed and are under construction at the European XFEL [16e], as shortly been explained in the following.
Starting from this introduction as a comprehensive summary of the basic principles, in the following, various FEL methods developed so far will be summarised, including the concept of filming chemical reactions in real time utilizing ultrafast high-flux X-ray sources [11,12,13,14,15,16], X-ray Diffraction and Crystallography for Condensed State Chemistry Studies—Crystallography with Ultrahigh Temporal and Ultrahigh Spatial Resolution [14, 17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52] and Applications in organic electronics and energy research [14, 53,54,55,56,57,58,59]; from From Local to Global: Ultrafast Multidimensional Soft X-ray Spectroscopy and Ultrafast X-ray Diffraction Shake Their Hands [60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76] and Applications in Bimolecular Reaction Studies and Photocatalysis [77,78,79,80] to Applications in Unimolecular Liquid Phase Reaction Dynamics [81,82,83,84,85,86,87,88,89] and Applications in Bioelectronics, Aqueous and Prebiotics Reaction Dynamics [90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108] to Applications in Biophysics and Gas Phase Biomolecules [109,110,111,112,113,114,115,116,117,118,119,120,121]; from Ultrafast Imaging of Gas Phase Reactions [122,123,124,125,126,127] and Applications in Nanoscience and Multiphoton-Ionisations [128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150] to Applications in Unimolecular Gas Phase Dynamics [122, 151,152,153,154,155,156,157,158,159,160,161,162,163] and Outlook.
2 The Concept: Filming Chemical Reactions in Real Time Utilizing Ultrafast High-Flux X-ray Sources
In a proof-of-principle experiment at the white beam beamline at the ESRF (The European Synchrotron Research Facility) in 2001, it has been demonstrated that high-flux, pulsed X-rays—as created with synchrotrons of the 3rd generation—can act as the “photons of choice” for studying the dynamics and kinetics of small chemical systems on their complex reaction landscape [1]. These studies have been used to define various expectation values for time-resolved experiments at free-electron lasers and saddling the ground for ultrafast X-ray experiments at these sources. Since then, also the phrase of recording the molecular movie has been born (Fig. 17.3) [2–6b].
Figure 17.3 summarizes the principles of such a “molecular movie” approach: after the initialization of a chemical reaction with a short laser pulse, ultrafast X-ray FEL snapshots take photographs of the X-ray spectroscopic or X-ray diffraction signal. By varying the time delay between laser pump and X-ray probe pulse, information about the structural changes as a function of time are collected.
Time-wise, the criterion for “recording the molecular movie” is given when the time resolution of the pump and probe sources meet the time scales of the structural dynamics investigated. The resolution criterion for structural dynamics studies is fulfilled in chemistry, when the refined structure allows for determining the electron density or the charge densities (which are equal in the redox state) around a moving atom. High-resolution X-ray crystallography studies contains such precision [2, 8,9,10,11,12,13,14,15,16, 21, 23, 25, 35, 44, 46, 51].
3 X-ray Diffraction and Crystallography for Condensed State Chemistry Studies—Crystallography with Ultrahigh Temporal and Ultrahigh Spatial Resolution
Crystallography with ultrahigh temporal and spatial resolution allows studying photochemical reactions beyond conventional quantum chemical approaches. Far beyond any present laboratory technique, time-resolved synchrotron (picosecond time resolution) and FEL (femtosecond time resolution) experiments emphasize the uniqueness of the pulsed, ultrafast, high brilliant and coherent X-ray methods and metrology. For chemical bond breaking and bond formation, the criterion for spatial resolution is met in periodic systems (crystallography) when 0.01–0.001Å resolution diffractograms yield high precision structural information [8,9,10,11,12,13,14,15,16, 21,22,23, 25, 35, 44, 46, 51].
Figure 17.4 reflects the changes of X-ray synchrotron beam characteristics when evolving from synchrotrons of the 2nd generation towards hard X-ray free electron lasers. The diffractograms have been collected on a molecular crystal of the same species, the same crystal quality and the same orientation. Utilizing broadband wiggler radiation in 2nd generation synchrotrons (F1/DORIS) Laue diffraction pattern have been collected. Taped undulator radiation of synchrotrons of the 3rd generation yields in quasi Pink-Laue diffractograms (ID09/ESRF).
Compared to the Pink Laue white beam at XPP as well as CXI beamline of LCLS, the FEL radiation is about one to two orders of magnitude smaller in bandwidth, allowing only the investigation of a statistical number of Bragg reflections for small molecular crystals when the crystal is rotated.
Small molecular crystallography at free-electron lasers could be quantitatively utilized for structure determination by the combination of traditional Laue crystallography and FEL- specific serial crystallography techniques with rapid sample exchange and based on a single shot data collection strategy analogous to the developments of time-resolved Laue diffraction at synchrotrons of the 3rd generation.
In contrast to conventional Laue crystallography, for normalization purposes during FEL experiments, every diffractogram needs to be associated to an online collected X-ray spectrum. Utilizing high X-ray energies well above 15 keV (use of the third harmonic and smaller X-ray/atom cross section) with no monochromatization in pink Laue modus reduces radiation damage so that with a monotonically running spindle and randomly changing X-ray wavelength with known X-ray spectral characteristics, various orientations under defined X-ray conditions can be collected. They are sufficient for determining the orientation matrix of small molecules and hence following the indexing of the collected diffractograms.
Since the studied materials are normally compounds of small amounts, in the presented approach highest quality crystals are stacked behind each other in a capillary (or other type of sample target holder) and high energy X-ray radiation is utilized for collecting high resolution diffraction patterns and minimizing accumulative radiation damage. Due to the monochromaticity of FEL X-ray beams even in its pink Laue mode, quasi Pink Laue diffraction pattern will be recorded for various orientations—allowing a precise determination of the orientation matrix of the small molecule crystals. Additionally, on a single shot base, the Bragg peak intensities are wavelength and X-ray intensity normalized (Fig. 17.5).
In the current example, unravelling the mechanisms of electron-transfer induced structural changes (ET), and the interplay of charge-transfer (CT) and structural reorganisations in complex molecular systems is of prime importance in both chemical and biological processes and has gained considerable importance over decades. ET/CT and the associated structural changes are pervasive, path to inevitably diverse processes occurring in nature, including light harvesting systems like photosynthesis to technological innovations such as solar energy converters and optical devices. It is challenging to trap the fleeting excited species or transient species and gain insight into the unprecedented dynamics which occurs in ultrafast time scale in the range of as to ps. Emerging scientific innovations in many synchrotrons and FELs, with high brilliance and extremely high photon flux have wide opened a new domain of research in investigating many ultrafast processes. Information about what happens immediately after the triggering of the reaction is satisfactory but to evaluate what happens next is crucial. In order to tackle these questions, we must know how fast the processes happen and what are the time scales of each processes we are interested in.
By employing time-resolved X-ray diffraction (TR-XRD) technique, the CT/ET reaction has been initiated by a laser pump pulse from the ground state to the excited state or the CT/ET state. The photo-induced subsequent structural changes have been monitored utilizing the pulsed structure of the X-ray beam by varying the time delay between the optical laser pump and X-ray probe pulses (pump/X-ray probe scheme) as been shown in Fig. 17.6.
In the following examples of structural dynamics of organic and metallo-organic systems by trapping charge transfer states using high brilliance Pink Laue time-resolved X-ray diffraction are presented. The photo-induced dynamics has been studied by looking from simple organic donor acceptor molecules (Fig. 17.7) to complex inorganic single crystalline systems. In the former the structural changes are induced by an ET/CT of an organic donor to an organic acceptor moiety, and in the later it is a induced by a metal to ligand charge transfer (MLCT) (see following chapter). Due to their high photo-conversion efficiencies and lifetimes, first are highly suited for solar cell developments, and last are highly suited as photo-catalysts.
The experiments have been performed combining high resolution static single crystal XRD studies utilizing a home-source (Bruker Apex II) system and P11 beamline of PETRA III at DESY. To map out the details of the potential landscapes, ultrafast, light-induced Laue diffraction studies of the pure organic system as well as the metal-complex have been performed at BioCARS, 14-ID beamline/Argonne (picosecond pink-Laue), ID09/ESRF (picosecond pink-Laue), XPP/CXI/LCLS (femtosecond pink-Laue) and P11/PETRA-III (picosecond, monochromatic). In the pure organic system within few hundreds of picoseconds electron density migration occurs and the structural changes are clearly visible from the photo difference map with prominent differences in the electron density maps at the electron donor and electron acceptor system (Fig. 17.7). In the metal-complex, it has been oberseved that upon photo-excitation the electron migration or the charge migration is mostly on the proximal atoms of the organic ligands from the metal center (not shown here).
Figure 17.7 depicts the refined result of such an experiment- the femtosecond structural dynamics or “molecular movie” of a molecular crystal, which consist of only light elements (carbon, nitrogen). The patented system has the most efficient optical light/electron transfer rate possible (100%), by utilizing quantum effects such as electron and structural dynamics pathways which cannot be described through the conventional Born-Oppenheimer approximation.
4 Applications in Energy Research
Understanding this “beyond Born-Oppenheimer” behaviour and combining the properties of this type of system with smart semiconducting plastic types of compounds, it is possible to build flexible, solid, plastic-type of solar cells and organic light emitting diodes with very high efficiency (Fig. 17.8).
Both as a consequence of successive technical developments, and based on the chemical rules and time laws derived during the various method development process, it has become possible to optimize functional performances of solar cell organic materials and devices (Fig. 17.8).
By moving the fundamental method developments into the application regime (again as a proof for the methods’ developments), the circle of promises closes that 3rd and 4th generation X-ray sources may help to optimize strategies for modern material performances. In order to test whether the structural dynamics laws derived through the “molecular movie” approach can have direct consequences for applications of the molecular system, electronic devices such as organic solar cells and organic light emitting diodes have been built and Fig. 17.8 presents such efforts.
As can be seen on the current voltage (I–V) curve, when combining with semiconducting plastic material (which by itself is not photo active), efficient organic solar cells with high mechanic flexibility and cheap in production can be designed.
Since the time-resolved X-ray methods allow for detangling “local-to-global” and “global-to-local” structural responses, desired functional actions of a device like energy storage can be distinguished from “energy-eating” processes based on non-desired heating and energy quenching processes. Figure 17.7 presents the structural mechanisms underlying an optimized all-over organic solar cell. Small atomic changes on the light-absorbing chromophore unit lead to a complete switching of its functional dynamics—from light absorbing solar cell devices [53,54,55,56,57,58,59] to a light emitting organic diode [54]. In another example the understanding of the crystallization processes of organic material out of time-resolved X-ray diffraction (TR-XRD) studies has been influenced by the optimization of the recycling process of molten PET bottles to ultra-hard polyethylene [56]. Such ultra-hard plastic material is currently used in every 2nd wind craft machine produced world-wide.
The current examples emphasize, however, that the real world, functional materials, pharmaceuticals, catalysts or energy converting materials are not always crystalline and far from being periodically ideally arranged as it could look like when performing model type of investigations. If the intrinsic spatial resolution of the system does not allow for such detailed investigations, a combination of ultrafast X-ray spectroscopy and ultrafast X-ray diffraction or scattering as the “local to global approach” deliver configuration and charge information of the molecules studied [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52, 60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76]. This approach will be described in the following chapter.
5 From Local to Global: Ultrafast Multidimensional Soft X-ray Spectroscopy and Ultrafast X-ray Diffraction Shake Their Hands
As ultrafast X-ray spectroscopy and X-ray diffraction can “shake their hands” in X-ray Free-electron laser science, they open up new ways to study complex chemical reactions.
X-ray diffraction [17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59] and X-ray spectroscopy [60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76] are complementary techniques. X-ray spectroscopy allows probing the electronic properties in an element-, orbital- and site-specific way, for example bonding or oxidation state changes [63]. Since one gets local information for the system under investigation the method is referenced as the local approach. In X-ray diffraction the structural changes of the whole bulk are probed which is termed as the global approach. With these approaches it is possible to get the overall structural properties of the target system. Furthermore, by applying both methods more complete information can be obtained. However, to follow whole reaction pathways or reaction intermediates between the start and end of a reaction, the experimental approaches have to be extended using the time-resolved method, i.e. the pump-probe scheme, as described in the previous section and shown in Fig. 17.9.
With the availability of the first X-ray FEL, FLASH at DESY in Hamburg, Germany, it became possible to implement X-ray spectroscopy and diffraction for investigating ultrafast chemical reaction processes. In the following, we present two pioneering soft X-ray experiments performed at the FEL facilities FLASH and LCLS.
The first example is a time-resolved X-ray diffraction measurement on silver-behenate [60–76] with an outlook towards combination of the liquid jet with X-ray spectroscopy, the second example is a femtosecond time-resolved X-ray spectroscopy experiment on iron-pentacarbonyl (Fe(CO)5) [78–81]. Figure 17.10a shows the apparatus which has been developed for such experiments at FELs. The ultrafast X-ray diffraction of a silver-containing redox system embedded in a supramolecular organic structure has been studied (Fig. 17.10b). The experiment is a proof-of-principle, utilizing FEL radiation for ultrafast X-ray diffraction of chemical systems in real-time. By investigating the time-evolution of the Bragg reflections (Fig. 17.10c) complex photo-induced transformation kinetics of partially photo-chemically induced and heat-propagation-influenced reaction kinetics has been found.
The decay curve depicts the propagation of the ultrafast transformation throughout the whole material. The black areas present the non-transformed material, the white areas the island of transformed material.
6 Applications in Bimolecular Reaction Studies and Photocatalysis
Another experiment in the field of soft X-ray spectroscopy has recently been worked out for studying photocatalysis. For pioneering time-resolved X-ray spectroscopy measurements the FLASH end station in Fig. 17.10 has been modified by adding a soft X-ray spectrometer in Rowland circle geometry [63, 66, 77,78,79,80]. This so called Liquid Jet (LJ) end station has then been successfully used in resonant inelastic X-ray scattering (RIXS) experiments on Fe(CO)5 at the LCLS-FEL at SLAC in Stanford, CA, USA. Similar end stations have been built to perform soft X-ray spectroscopy experiments at high flux X-ray facilities at DESY/Hamburg [15] and HZB/Berlin. In the above mentioned experiment [77,78,79,80], the dissociation of iron-pentacarbonyl (Fe(CO)5) in ethanol has been studied in real-time. After optical excitation with 266 nm photons, Fig. 17.11a, Fe(CO)5 dissociates into iron-tetracarbonyl (Fe(CO)4) and carbon monoxide (CO) under solvent-assistance. For every time-delay, the incident monochromatic FEL photon energy has been scanned over the Fe 2p edge, and the X-ray emission spectra have been recorded.
The time evolution was deduced from differences of the pumped (positive time-delay) and the un-pumped (negative time-delay) Fe(CO)5 emission spectra. Figure 17.11 summarizes the ethanol-assisted Fe(CO)5 photo-dissociation pathways and simulations are compared to the experiment. The complexity of reaction increases due to the formation and decay of a triplet state, where Fig. 17.11b–e summarises the evolution of the valence-electronic structure of Fe(CO)4 in ethanol upon femtosecond spin crossover and complex formation.
The involved orbitals are assigned according to the Fe 2p and 3d, or ligand 2p characteristics, and according to the symmetry along the Fe–CO bonds. The star (*) in Fig. 17.11b, marks the antibonding orbitals of the electron configuration of the Fe(CO)5 ground state and the single-electron transitions of the laser pump—X-ray probe processes. The dissociation of (Fe(CO)5 \(\longrightarrow \) Fe(CO)4 + CO) is initiated by the optical \(\mathrm {d}_\pi \rightarrow 2 \pi ^*\) excitation. The RIXS measurements at the Fe L3-absorption edge to final valence-excited states involves the probing of the \(\mathrm {d}_\pi \rightarrow \mathrm {d}_\sigma ^*\) transition. In Fig. 17.11(c, top), the difference RIXS spectra (RIXS intensity of incident photon energy versus energy transfer in eV) of the summed pumped and un-pumped sample is illustrated. Figure 17.11(c, bottom) displays the time structure in the regions (1–4) in comparison to simulated populations of the excited (E) and triplet (T) states and ligated complex (L). Figure 17.11d shows the measured RIXS spectra for Fe(CO)5 at negative time delays and the difference after delay intervals of 0–700 fs and 0.7–3.5 ps respectively (color-encoded). By subtracting the negative time delay with a weight of 0.9, the pumped contributions are isolated (top: Fe(CO)5, ground state (negative delays, probe before pump, scattering to \(\mathrm {d}_\pi ^7\mathrm {d}_\sigma ^{*1}\) and \(\mathrm {d}_\pi ^72\pi ^{*1}\) marked by middle/bottom: difference intensities for 0–700 fs and 0.7–3.5 ps time delays). The experimental data is compared to RIXS calculations displayed in Fig. 17.11e. Simulated Fe L3-RIXS intensities and molecular-orbital diagrams of Fe(CO)5 in the ground and hot state and Fe(CO)4 in various valence excited states are depicted.
The \(2p \rightarrow \mathrm {LUMO}\) resonance positions and \(\mathrm {d}_\pi \rightarrow \mathrm {d}_\sigma ^*\) RIXS transitions are marked by arrows. The RIXS pattern at early time evolution can only be reproduced when a complex between the Fe(CO)4 with the solvent is taken into account.
7 Applications in Unimolecular Liquid Phase Reaction Dynamics
In the hard X-ray regime [81,82,83,84,85,86,87,88,89], the “local to global” approach has also been established by combining X-ray spectroscopy with X-ray scattering techniques. The ultrafast structural dynamics of various metal organic systems has been studied applying these techniques [84, 88, 89].
8 Applications in Bioelectronics, Aqueous and Prebiotics Reaction Dynamics
In bioelectronics, aqueous and prebiotics reaction dynamics and biophysics, the ultrafast photon-in/photon-out developments utilizing high flux X-ray sources allow investigating the properties of biorelevant solvents and proteins during their structural reactions [90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108, 115, 116, 118, 121]. The literature-referenced examples include various types of small up to macromolecular model systems studied with X-ray radiation of ultrashort, high flux X-ray sources—X-ray scattering on quasi-periodic systems (Fig. 17.12) [90, 94,95,96,97,98,99,100,101,102,103], X-ray scattering on macromolecules (Fig. 17.13) and (Fig. 17.14) [90, 115, 116, 118, 121] and X-ray spectroscopy (Fig. 17.15) [91,92,93, 104,105,106,107,108].
Two examples of dynamical studies of soft condensed matter via high-flux time-resolved X-ray scattering will be given [90,91,92,93,94,95,96,97,98,99,100,101,102,103,104,105,106,107,108, 115, 116, 118, 121]: first, the studies of the dynamics of a phase transition of a liquid crystal-to-microemulsion system (Fig. 17.12) [95], and second, a real-time study of complex protein dynamics (Fig. 17.13/Fig. 17.14) [115, 116] will be given.
In liquid crystal type of soft condensed matter systems (Fig. 17.12), a manifold of phase-ordering transitions relevant to chemical and biological systems occur, ranging from liquids to self-assembled soft solids (like membranes or liquid crystals). In the present case the dynamics of the driving forces (activation energy and entropy) of a liquid crystal-to-microemulsion phase transition has been studied (Fig. 17.12 (left)). The purpose of this work was to clarify the influence of concentration effects of the amphiphilic molecules on the nature of these self-assembly processes.
By photosensitization of the model system (polyalkylglycolether (C10E4), water, decane, and cyclohexane) with laser dyes, the phase transition could effectively be photo-induced and controlled through the absorption of optical photons (as a photo-induced phase transition, PIPT). The photo transformation conditions were chosen in such a way that the system was in thermal equilibrium as starting conditions.
By applying time-resolved photo small-angle X-ray scattering it has been found that the conversion process depends on the surfactant concentration and the activation energy, which is observable through the length of the induction time (Fig. 17.12 (right)). The phase-transition, though photo-triggered, is still diffusion controlled in the rate-determining steps.
In the second example, X-ray scattering techniques, comprising of small-angle/wide-angle X-ray scattering (SAXS/WAXS) techniques are increasingly used to characterize the structure and interactions of biological macromolecules and their complexes in solution (Figs. 17.13 and 17.14) [90, 94,95,96,97,98,99,100,101,102,103, 115, 116, 118, 121]. It is a method of choice to characterize flexible, partially folded and unfolded protein systems. X-ray scattering is the last resort for proteins that cannot be investigated by crystallography or NMR and acts as a complementary technique with different biophysical techniques to answer challenging scientific questions. The marriage of the X-ray scattering technique with the fourth dimension “time” yields structural dynamics and kinetics information for protein motions in hierarchical timescales from picoseconds to days (Fig. 17.13).
In the “fourth-dimension – time” of X-ray scattering technique (Fig. 17.13) the timescales accessible range from hours down to femtoseconds, even for investigating non-photoactive protein dynamics with different time-resolved X-ray scattering techniques. Various time-resolved and in-situ X-ray scattering techniques listed are complementary to the photon-triggered time-resolved X-ray scattering techniques and can be adaped to structural dynamics investigations of ubiquitous non-photoactive proteins.
Depending on the time scale of the system studied, it has been demonstrated that it is furthermore possible to merge X-ray scattering techniques like diffuse X-ray scattering with pressure jump, temperature jump, electric field modulations, and structural freezing methods or, on the chemical modulation side, with, rapid mixing or photo-switching methods.
Figure 17.13 summarises typical X-ray scattering signal changes—inherent (a), as pressure-jump (b), in electric-field modulations (c), as electromagnetic field modulations (d), as structural freezing (e) and in small angle X-ray scattering experiments coupled with size-exclusion chromatography (SEC) technique (f). Special attention is given to rapid-mixing approaches with the help of microfluidic devices (g) and (Fig. 17.14). Various techniques listed in the summary figure have independently been developed in neighbor projects of the collaborative research center (see “references” and references therein).
Figure 17.14 presents a scheme for a rapid-mixing time-resolved small angle X-ray scattering experiments for the investigation of the ubiquitin unfolding process as model system and model process. Figure 17.14a presents the 20-microchannel continuous-flow microfluidic device and Fig. 17.14b the time-resolved small angle X-ray scattering (SAXS) setup for the kinetic ubiquitin unfolding studies (proving the secondary structure unfolding on the millisecond time scale), followed by the integrated rapid mixing SAXS experimental setup at the cSAXS beamline, PSI Switzerland.
The third example (of [91,92,93, 104,105,106,107,108]) concentrates on the use of multidimensional X-ray spectroscopy for studying the dynamics in soft condensed matter, here the dynamics of ions in aqueous solutions (Fig. 17.15). Hydration shells around ions are crucial for many fundamental biological and chemical processes. Their local physicochemical properties are quite different from those of bulk water and hard to probe experimentally.
By combining high-resolution soft X-ray spectroscopy using liquid jet technology as core hole clock spectroscopy method (Fig. 17.15 (left)) with molecular dynamics simulations and ab initio electronic structure calculations, at the molecular level the water-ion interaction in MgCl2 solution has been elucidated.
The results reveal that salt ions mainly affect the electronic properties of water molecules in close vicinity. Furthermore, in the first solvation shell the oxygen K-edge X-ray emission spectrum of water molecules differs significantly from that of bulk water. Ion-specific effects are identified by fingerprint features in the water X-ray emission spectra. While Mg2+ ions cause a bathochromic shift of the water lone pair orbital, the 3p orbital of the Cl− ions causes an additional peak in the water emission spectrum at around 528 eV (Fig. 17.15 (right)).
9 Applications in Biophysics and Gas Phase Biomolecules
Prolongating from the already presented techniques of combining X-ray scattering techniques like diffuse X-ray scattering with pressure jump, temperature jump, electric field modulations, and structural freezing methods or, on the chemical modulation side, with, rapid mixing or photo-switching methods and their successful application to biophysical questions [90, 94,95,96,97,98,99,100,101,102,103, 115, 116, 118, 121] or the application of core hole clock and multidimensional X-ray spectroscopy techniques towards aqueous and pre-biotics questions [91,92,93, 104,105,106,107,108] or novel liquid jet developments for biophysical research [120], in X-ray spectroscopy various other coupling techniques have been successfully proven.
The combination of synchrotrons or free-electron laser radiation with techniques, such as electrospray ionization mass spectrometry, allows deriving entirely novel experimental techniques for investigating macromolecules [109,110,111,112,113,114,115,116,117,118,119,120,121]. E.g. a mass spectrometric study on gas-phase ubiquitin at FLASH has revealed a fast local structural response, leading to small fragments with yields increasing linearly with photon intensity [109, 119].
Investigating the interaction of light with biologically relevant molecules has gained interest for a wide variety of research fields including photochemical reactions such as light harvesting as well as radiation damage in proteins and DNA related to cutting-edge cancer treatment techniques. However, in the condensed phase, disentangling direct and indirect radiation effects is often difficult [109,110,111,112,113,114,115,116,117,118,119,120,121].
In the beginning, studies on isolated polyatomic molecules in the gas phase were limited to small molecules, which are stable against thermal decomposition. In order to advance to more complex biomolecular systems, a novel apparatus has been designed. This mobile setup combines an electrospray ionization source, radio frequency (RF) mass filters, an RF trap and a mass spectrometer, which as a unity can be interfaced with different photon sources (see Fig. 17.16). Electrospray ionization introduces biomolecular ions from solution into the gas phase, allowing for studies of molecular systems in a well-defined state [109, 111,112,113,114, 119].
The coupling of electrospray ionization sources with synchrotrons [109, 111,112,113,114] and free-electron lasers [119] opens the way to the investigation of the electronic structure of biomolecular systems and of a fine description of their relaxation mechanisms in the VUV and soft X-ray energy range. The wide-ranging photon energy available at the synchrotrons enables systematic studies of ionization and dissociation as a function of the photon energy. Inner-shell excitations provide a localized site of energy deposition.
The extremely high photon flux and fs pulse duration offered by free-electron lasers allow studying the molecular properties in intense fields. Furthermore, using the assets of free-electron lasers in a pump-probe scheme enables the study of the dynamics of charge migration and charge transfer within gas-phase biomolecules.
In the VUV to soft X-ray regime, strong indications have been found that photoabsorption within small peptides induces fast loss of aromatic amino acid side chains through repulsive states, occurring before redistribution of the internal energy. The very fast loss of side chains thus efficiently cools the residual peptide, and may enable the survival of early functional peptide substructures under photon irradiation. This dissociation is mainly caused by photoabsorption in the peptide backbone, which seems to trigger ultrafast charge migration to the side chains, without leading to fragmentation to the backbone itself [111,112,113,114, 119].
In the following, X-ray/peptide or X-ray/protein interactions have been studied as a function of peptide size. Small peptides like leucine enkephalin [109, 112] (five amino acid residues) dissociate into small immonium fragments, whereas bigger proteins like cytochrome c (106 amino acids residues) undergo only multiple ionizations and no fragmentation. The size dependency has been explained by considering that the average excess energy left in the peptide is redistributed over the ro-vibrational modes of the molecule and averaged over the various degrees of freedom. Therefore the larger proteins can handle much more energy due to more degrees of freedom to redistribute the energy.
First studies of a gas-phase protein (ubiquitin, 76 residues) at the free-electron laser in Hamburg, FLASH, has revealed two different photoabsorption regimes: non-dissociative ionization in the few-photon regime (pulse energy of 0.1 \(\upmu \)J), in contrast to side-chain losses in the multi-photon regime (pulse energy of 2.3 \(\upmu \)J) [119]. The yields of these side-chain fragments increase linearly with the number of photons in the pulses. No region has been found where intermediate fragments due to backbone scission prevail. These effects suggest that in the XUV multiphoton regime, proteins seem to react as an ensemble of small peptides losing the side chains in fast local fragmentation processes.
Near edge X-ray absorption fine structure spectroscopy (NEXAFS) probes transitions between atomic core levels and orbitals of the molecular bonding states of intra-molecular neighbours. Therefore, NEXAFS is a powerful structural tool that provides information on the electronic structure. Data taken by near edge X-ray absorption mass spectrometry (NEXAMS) of gas-phase oligonucleotides [114], peptides [109, 112] (and references therein) and proteins [114c,118,119] show (\(\pi ^*\), \(\sigma ^*\)) transitions and Rydberg states similar to conventional NEXAFS spectra of thin films and liquids. Additional structural and dissociation dynamics within the molecules can be extracted from the NEXAMS information of the different individual ionization and dissociation products. Moreover, the gas-phase NEXAMS method can be sensitive to the secondary structure of proteins as shown in the study of melittin [113].
In the photoexcitation case of the protein melittin, the molecules end up singly ionized after excitation of the electron and singly Auger emission. The yields of the singly ionized parent peak of different initial charge states of melittin against the photon energy around the carbon 1s edge are shown in Fig. 17.17 (top). In the photoionization case, the molecules end up doubly ionized after ionization of the electron into the continuum and singly Auger electron emission. The yields of the doubly ionized parent peak are shown in Fig. 17.17 (bottom).
A decrease of the resonance (\(1s-\pi ^*_\mathrm {CO}\)) with increasing charge state is observed, an opposite trend as in the photoexcitation case. The NEXAMS properties and photoionisation behaviour are explained as additional ionization of the molecule by secondary electrons and the probability of the molecules being hit by these electrons depending on their geometries. Consequently, a helical and more compact structure with the charge state \(2+\) the molecule has a higher probability to be hit again by an escaping electron compared to linear structures with four charges.
10 Ultrafast Imaging of Unimolecular Gas-Phase Reactions
The advent of X-ray free-electron lasers enabled not only novel studies in the condensed phase, as described in the first parts of this chapter, but also brought forward unprecedented possibilities to study dynamical processes in the gas phase. The very short and very intense X-ray pulses made it possible, for the first time, to probe ultrafast photo-induced molecular dynamics by electron or ion momentum spectroscopy following multiple, element-specific inner-shell absorption.
These new 4th generation light sources also called for novel, dedicated instrumentation (Fig. 17.18). To this end, different endstations have been developed, initially in particular for the use at the atomic, molecular, and optical physics (AMO) beamline, which was the first beamline to become operational at the LCLS [122, 122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150,151,152,153,154,155,156,157,158,159,160,161,162,163] in 2009. Several of the early, pioneering experiments from 2009 to 2012 have been performed at the AMO beamline in the CFEL-ASG MultiPurpose (CAMP) endstation [125, 127], see Fig. 17.18, which was developed within the Max-Planck Advanced Study Group (ASG) at the Center for Free-Electron Laser Science (CFEL) in Hamburg. Experiments in this instrument range from X-ray imaging of biomolecules, nanocrystals, and clusters [122, 125, 127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150] to (time-resolved) ion and electron spectroscopy on atoms and small gas-phase molecules [122, 122,123,124,125,126,127, 151,152,153,154,155,156,157,158,159,160,161,162,163]. Since 2014, CAMP is a permanent user endstation at FLASH/BL1 at DESY in Hamburg [124], and its successor, LAMP, has become operational at the AMO beamline at the LCLS [16b].
11 Applications in Nanoscience and Multiphoton-Ionisation
Moreover, the high-field physics (HFP) instrument has been developed at the LCLS [128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150], housing an ion momentum spectrometer and several electron time-of-flight spectrometers mounted under different angles. It also offers a pulsed, supersonic molecular beam, delivering gas-phase molecules to the interaction region. The examples given in the following, as well as multiple other pioneering gas-phase studies have been conducted in the HFP instrument [122,123,124,125,126,127,128,129,130,131,132,133,134,135,136,137,138,139,140,141,142,143,144,145,146,147,148,149,150].
12 Applications in Unimolecular Gas Phase Dynamics
Gas-phase FEL experiments allow questioning fundamental definitions in chemistry, for example the investigation of processes beyond the Born-Oppenheimer approximation. As an example, a UV-pump, X-ray probe study of two complementary halomethane molecules with different photochemistry is shown here [122, 122,123,124, 126, 151,152,153,154,155,156,157,158,159,160,161,162,163].
In Fig. 17.19, the schematic potential energy curves (PECs) of iodomethane (CH3I) and fluoromethane (CH3F) are displayed, illustrating that the different halogen species give rise to qualitatively different PECs [122, 152,153,154,155, 161, 163]. One reason for this is the considerably different electronegativity of iodine and fluorine, stabilizing the C–F bond in contrast to the C–I bond. Upon absorption of one 267 nm UV photon, CH3I dissociates into two neutral fragments, CH3 + I, whereas in CH3F, no PEC is resonantly accessible at 4.6 eV. In the latter case, absorption of at least three UV photons in the same molecule populates several higher-lying ionic PECs, also resulting in dissociation of the molecules.
After a tunable time delay, an intense X-ray pulse (727 eV, 1 mJ) probes the dissociating system by ionizing predominantly the iodine (3d) or the fluorine (1s) level, respectively, because of their large absorption cross section (3.3 Mb for I and 0.4 Mb for F, compared to 0.1 Mb for CH3), resulting in a localized positive charge on the halogen [122, 152,153,154,155, 161, 163].
At these very high X-ray intensities, a single molecule can absorb many photons, such that very highly charged ions up to I21+/F4+ and C4+ are created.
As the charge is initially created locally at the halogen atom though, the fact that highly charged carbon ions are also detected already shows that the charge rearranges within the molecule before or during the fragmentation.
In Fig. 17.20, the calculated electrostatic potentials of an I6+ + CH3 are plotted for three different internuclear distances between the two fragments, together with the binding energy of the highest occupied orbital. In the intact molecule (a), the electrons are delocalized, but as the fragments move apart the potential barrier rises, until at a certain critical distance (b), it reaches the electron binding energy.
Therefore, for larger distances (c) the electrons can classically be regarded as localized at one of the two fragments. It is this transition from a bound molecule to isolated atoms that is probed by time-resolved ion spectroscopy [122, 152,153,154,155, 161, 163].
The delay-dependent time-of-flight peaks of selected ions of iodomethane and fluoromethane are shown in Fig. 17.21. It is evident that the fragmentation patterns of the two molecules are qualitatively different. For iodine charge states \({\ge }\mathrm{I}^{4+}\), the appearance of low-energy ions at positive delays is clearly visible (channel 3 in Fig. 17.21a).
Signatures of long-distance intramolecular electron transfer have been observed for both, CH3I and CH3F, and the reconstructed critical distances (up to 15 Å for I\(^{21+}\)) are in good agreement with a classical over-the-barrier model.
These ions originate from the pump-probe process as indicated for iodomethane in Fig. 17.21, and can be used to extract the critical internuclear distance, up to which electron transfer from methyl to iodine is classically allowed for a given charge state [122, 152,153,154,155, 161, 163].
Two other channels can be seen in Fig. 17.21 that correspond to Coulomb explosion of intact molecules by only the FEL (1) and to ionic dissociation induced by multi-photon UV absorption (2), as illustrated for fluoromethane in Fig. 17.21, which also occurs with a lower probability in CH3I. The low-energy channel is absent in the fluorine ions.
13 Outlook and Conclusion: First High-Repetition Frequency, Ultrafast Hard and Soft X-ray Studies of Chemical Reactions at the European X-ray Free Electron Laser
The current chapter tried to give a comprehensive summary of the very first and pioneering developments of chemical research tools utilizing soft and hard X-ray Free Electron Laser radiation. The structural dynamics and “molecular movie” concept has been introduced and confirmed in various states of matter and in different type of chemical reactions: in the gas phase (unimolecular), in the liquid phase (uni- and bimolecular) and in the solid state.
Novel experimental FEL concepts have been introduced which needed to be developed for the different chemical systems and reaction classes, and their pioneering applications in the various fields of FEL chemistry studies—from molecular reaction studies, through photocatalysis to energy research and biophysics—have been demonstrated. All reported experiments were of pioneer type concerning its kind. It has successfully been shown that it is possible to follow chemical reactions with FEL radiation in real time in the gas phase, in the liquid phase, and in the solid phase. Comparisons to other exiting techniques developed at free-electron laser sources have been given.
As due to the coincidence between the time, where FELs in the soft and hard X-ray regime came first into operational mode (2005–2018), and the start and running time of the Collaborative Research Center SFB755 Nanoscale Photonic Imaging (2007–2019), FEL milestones for chemical research have directly and right-on-time been reported within the SFB755. From our side, therefore, the SFB covers the most precious “life-time” of our experimental efforts so far, making it most important, essential and special for us as intellectual exchange and scientific support platform, and as a common effort of the Göttingen Campus. Every further development being sketched in the last paragraph can be built on the scientific construction platform supported by the SFB.
Since end 2017 the European X-ray Free-electron Laser as the first FEL of the 2nd generation is operationable. It unifies MHz repetition frequency capabilities with highest brilliance, stable time-synchronisation (allowing for view femtosecond time-resolved experiments), highest degree of coherence, tunability etc. allowing for experiments in an evolution to pioneering experiments of 1st generation FELs but also towards novel experimental strategies employing multidimensional X-ray spectroscopy or ultrafast inelastic scattering techniques. In the “molecular movie” field first feasibility and demonstration experiments have been performed and are discussed in the context of existing X-ray FEL chemistry studies. In the next 10 years novel superconducting LINAC technologies will come in operation (i.e. in LCLS-II) allowing for expanding existing techniques and a shift of experimental paradigm from proof-of-concept studies towards sample-curiosity driven X-ray experiments.
14 Acknowledgements
The Helmholtz Society is thanked for continuous financial support and DESY for preferred access to X-ray instrumentation. DESY staff is thanked for their competent help in large scale facility technical and computer support. Up to 2017, the Max Planck Society is acknowledged for continuous financial support. The workshops and chemical facility of the Max Planck Institute for Biophysical Chemistry is thanked for their competent help in chemical synthesis, analysis and technical design of the micro apparatus and computer support.
When the SFB755 “Nanoscale Photonic Imaging” started, in 2006, synchrotron researchers faced their next challenge in developing and proving X-ray Free Electron Laser Science. Throughout and fully, over the last 12 years research work of method developments utilizing X-ray free-electron lasers and synchrotron research (method development) as been presented in this chapter have been financially supported by the Deutsche Forschungsgemeinschaft within the Collaborative Research Center SFB755 “Nanoscale Photonic Imaging” (project B03 and project B10). Systems- and sample-related research work also presented in this chapter have been funded through the Collaborative Research Center SFB1073 “Atomic-scale Control of Energy Conversion” (project B06 and C02). Furthermore, the German Academic Exchange Service DAAD, the Alexander von Humboldt Foundation AvH, the Fonts of the Chemical Industry FCI, the Aventis Foundation, “Niedersachsen Vorab”, the Peter-Paul-Ewald Fellowship program of the Volkswagen Foundation (No 87008) are thanked for financial support.
The independent young investigator groups of Daniel Rolles (“Watching Chemistry in Action” (VH-NG-904, 2012–2017), now Kansas State U) and Sadia Bari (“Structure and Dynamics of Gas Phase Biomolecules” (VH-NG-1104, 2016-now) have additionally financially been supported by the project B03 of the SFB755 (see “references”).
The Advanced Study Group of the Max Planck Society is thanked for financial support 2006–2011, the Initiative and Networking Fund of the Helmholtz Association is thanked from 2012 on (programs: VH-NG-1104, NV-NG-904, HG-recruitment, HG-Innovation “ECRAPS”, HG-Innovation “HESEB/SESAME”, DSF, DASHH, DGP, CMWS).
The German-Israeli Foundation for Scientific Research and Development (GIF) and the Technion Society/BMBF are thanked for support in education and research.
Over the last decade, beamline staff of the Helmholtz Center Berlin (HZB—Prof. A. Foehlisch and his team) is thanked for the fruitful collaborations, experimental support and hospitality. Beamline responsibles of the European Synchrotron Radiation Facility (ID09, ID11, ESRF—Prof. M. Wulff and his team), the Advanced Photon Source (ID14, APS—V. Srajier and the team), the Swiss Light Source (cSAXS (A. Menzel), SLS), the Stanford Synchrotron Radiation Facility (SPEAR, SSRL), PETRA III (P01 (H. Yavas), P03 (S. Roth), P04 (J. Viefhaus), P10 (M. Stumpf) and P11 (A. Burkhardt)) and the Advanced Light Source (ALS) are thanked for their fruitful collaborations, experimental support and hospitality.
Staff and beamline scientists of the free-electron laser FLASH (BL1-BL3, CAMP (B. Erk); E. Ploenjes, B. Manschwetus, R. Treusch, M. Kuhlmann and the teams) @ DESY, staff and beamline scientists of the free-electron laser LCLS (AMO (J. Bozek, C. Bostedt), SXR (B. Schlotter, J. Turner), XPP (D. Fritz) and CXI (M. Messerschmidt, S. Boutet)) @ SLAC, staff and beamline scientists of the Free Electron Laser SACLA @ SPRING-8/Riken and staff and—finally—the European X-ray free-electron laser European XFEL in Schenefeld and their beamline staff (FXE (C. Bressler), SPB (A. Mancuso), SCS (A. Scherz) and SQS (M. Meyer)) are deeply acknowledged for their collaborations, support and hospitality with the DESY/FS-SCS group members.
Use of the Linac Coherent Light Source (LCLS), SLAC National Accelerator Laboratory, is supported by the U.S. Department of Energy, Office of Science, Office of Basic Energy Sciences under Contract No. DE-AC02-76SF00515.
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Lindenberg, A.M., Larsson, J., Sokolowski-Tinten, K., Gaffney, K., Blome, C., Synnergren, O., Sheppard, J., Caleman, C., MacPhee, A.G., Weinstein, D., Lowney, D.P., Allison, T., Matthews, T., Falcone, R.W., Cavalieri, A.L., Fritz, D.M., Lee, S.H., Bucksbaum, P.H., Reis, D.A., Rudati, J., Mills, D.M., Fuoss, P.H., Stephenson, G.B., Kao, C.C., Siddons, D.P., Pahl, R., Als-Nielsen, J., Dusterer, S., Ischebeck, R., Schlarb, H., Shulte-Schrepping, H., Tschentscher, T., Schneider, J., Hignette, O., Sette, F., Chapman, H.N., Lee, R.W., Hansen, T.N., Techert, S., Wark, J.S., Bergh, M., Huldt, G., van der Spoel, D., Timneanu, M., Hajdu, J., von der Linde, D., Akre, R.A., Bong, E., Emma, P., Krejcik, P., Arthur, J., Brennan, S., Luening, K., Hastings, J.B.: Atomic-scale visualization of inertial dynamics. Science 308(5720), 392–395 (2005). https://doi.org/10.1126/science.1107996
Messerschmidt, M., Tschentscher, T., Cammarata, M., Meents, A., Sager, C., Davaasambuu, J., Busse, G., Techert, S.: Ultrafast potential energy surface softening of one-dimensional organic conductors revealed by picosecond time-resolved laue crystallography. J. Phys. Chem. A 114(29), 7677–7681 (2010). https://doi.org/10.1021/jp104081b
More, R.: Untersuchung zur strukturdynamik organischer molekularer halbleiter: Photochemische festkörperreaktionen—protonentransfer in carbonsäuredimeren (2012)
Moré, R., Busse, G., Hallmann, J., Paulmann, C., Scholz, M., Techert, S.: Photodimerization of crystalline 9-anthracenecarboxylic acid: a nontopotactic autocatalytic transformation. he J. Phys. Chem. C 114(9), 4142–4148 (2010). https://doi.org/10.1021/jp909513v
Moré, R., Scholz, M., Busse, G., Busse, L., Paulmann, C., Tolkiehn, M., Techert, S.: Hydrogen bond dynamics in crystalline \(\beta \)-9-anthracene carboxylic acid—a combined crystallographic and spectroscopic study. Phys. Chem. Chem. Phys. 14(29), 10,187 (2012). https://doi.org/10.1039/c2cp40216e
Neutze, R., Techert, S.: Watching ultrafast chemistry with FEL radiation. TESLA Tech. Des. Rep.—Part I, (2001)
Quevedo, W., Busse, G., Hallmann, J., Moré, R., Petri, M., Krasniqi, F., Rudenko, A., Tschentscher, T., Stojanovic, N., Düsterer, S., Treusch, R., Tolkiehn, M., Techert, S., Rajkovic, I.: Ultrafast time dynamics studies of periodic lattices with free electron laser radiation. J. Appl. Phys. 112(9), 093,519 (2012). https://doi.org/10.1063/1.4764918
Rajkovic, I., Busse, G., Hallmann, J., Moré, R., Petri, M., Quevedo, W., Krasniqi, F., Rudenko, A., Tschentscher, T., Stojanovic, N., Düsterer, S., Treusch, R., Tolkiehn, M., Techert, S.: Diffraction properties of periodic lattices under free electron laser radiation. Phys. Rev. Lett. 104(12) (2010). https://doi.org/10.1103/physrevlett.104.125503
Scholz, M.: Ultrafast X-ray diffraction of metalloorganic compounds (2010)
Schotte, F., Techert, S., Anfinrud, P., Srajer, V., Moffat, K., Wulff, M.: Recent advantages in the generation of pulsed synchrotron radiation suitable for picosecond time-resolved X-ray studies. Wiley-Interscience (2002)
Sørensen, H.O., Schmidt, S., Wright, J.P., Vaughan, G.B.M., Techert, S., Garman, E.F., Oddershede, J., Davaasambuu, J., Paithankar, K.S., Gundlach, C., Poulsen, H.F.: Multigrain crystallography. Zeitschrift für Kristallographie 227(1), 63–78 (2012). https://doi.org/10.1524/zkri.2012.1438
Techert, S.: Current developments in time-resolved X-ray diffraction. Crystallogr. Rev. 12(1), 25–45 (2006). https://doi.org/10.1080/08893110600688873
Techert, S.: Watching chemistry with femtosecond X-rays, scientific case of an energy recovery linac (2006)
Techert, S.: Structural changes during the photoswitching of matter. MPIbpC News 10, 1–8 (2007)
Techert, S.: Ultrafast photochemistry. In: Tschentscher, T., Rousse, A. (eds.) Conference Proceedings on X-ray Investigations of Ultrafast Processes, pp. 410–445. Hasylab at DESY, Hamburg (2007)
Techert, S.: Concepts of structural dynamics investigations in chemical research, pp. 129–139. Springer Netherlands (2014)
Techert, S., Zachariasse, K.A.: Structure determination of the intramolecular charge transfer state in crystalline 4-(diisopropylamino)benzonitrile from picosecond X-ray diffraction. J. Am. Chem. Soc. 126(17), 5593–5600 (2004). https://doi.org/10.1021/ja0379518
Veedu, S.T., Cao, D., Lavy, T., Botoshansky, M., Kaftory, M.: Unexpected molecular flip in solid-state photodimerization. Cryst. Growth & Des. 13(2), 936–941 (2013). https://doi.org/10.1021/cg3016707
Grossmann, P., Rajkovic, I., Moré, R., Norpoth, J., Techert, S., Jooss, C., Mann, K.: Time-resolved near-edge X-ray absorption fine structure spectroscopy on photo-induced phase transitions using a tabletop soft-X-ray spectrometer. Rev. Sci. Instrum. 83(5), 053,110 (2012). https://doi.org/10.1063/1.4718936
Idzik, K.R., Cywiński, P.J., Kuznik, W., Frydel, J., Licha, T., Ratajczyk, T.: The optical properties and quantum chemical calculations of thienyl and furyl derivatives of pyrene. Phys. Chem. Chem. Phys. 17(35), 22758–22769 (2015). https://doi.org/10.1039/c5cp03013g
Mildner, S., Hoffmann, J., Blöchl, P.E., Techert, S., Jooss, C.: Temperature- and doping-dependent optical absorption in the small-polaron systemPr1-xCaxMnO3. Phys. Rev. B 92(3) (2015). https://doi.org/10.1103/physrevb.92.035145
Petri, M.: Private communication (2016)
Raiser, D.: Development of ultrafast optical methods for the study of the structural dynamics of complex solids (2017)
Raiser, D., Mildner, S., Ifland, B., Sotoudeh, M., Blöchl, P., Techert, S., Jooss, C.: Evolution of hot polaron states with a nanosecond lifetime in a manganite perovskite. Adv. Energy Mater. 7(12), 1602,174 (2017). https://doi.org/10.1002/aenm.201602174
Veedu, S.T., Raiser, D., Kia, R., Scholz, M., Techert, S.: Ultrafast dynamical study of pyrene-n, n-dimethylaniline (PyDMA) as an organic molecular diode in solid state. J. Phys. Chem. B 118(12), 3291–3297 (2014). https://doi.org/10.1021/jp4121222
David, C., Rösner, B., Döring, F., Guzenko, V., Koch, F., Lebugle, M., Marschall, F., Seniutinas, G., Raabe, J., Watts, B., Grolimund, D., Yin, Z., Beye, M., Techert, S., Viefhaus, J., Falkenberg, G., Schroer, C.: Diffractive X-ray optics for synchrotrons and free-electron lasers. Microsc. Microanal. 24(S2), 268–269 (2018). https://doi.org/10.1017/s1431927618013673
Döring, F., Marschall, F., Yin, Z., Rosner, B., Beye, M., Miedema, P., Kubicek, K., Glaser, L., Raiser, D., Soltau, J., Guzenko, V.A., Viefhaus, J., Buck, J., Risch, M., Techert, S., David, C.: ID-full field microscopy of elastic and inelastic scattering with transmission off-axis fresnel zone plates. Microsc. Microanal. 24(S2), 184–185 (2018). https://doi.org/10.1017/s1431927618013260
Hallmann, J., Grübel, S., Rajkovic, I., Quevedo, W., Busse, G., Scholz, M., More, R., Petri, M., Techert, S.: First steps towards probing chemical systems and dynamics with free-electron laser radiation—case studies at the FLASH facility. J. Phys. B: At. Mol. Opt. Phys. 43(19), 194,009 (2010). https://doi.org/10.1088/0953-4075/43/19/194009
Kunnus, K., Rajkovic, I., Schreck, S., Quevedo, W., Eckert, S., Beye, M., Suljoti, E., Weniger, C., Kalus, C., Grübel, S., Scholz, M., Nordlund, D., Zhang, W., Hartsock, R.W., Gaffney, K.J., Schlotter, W.F., Turner, J.J., Kennedy, B., Hennies, F., Techert, S., Wernet, P., Föhlisch, A.: A setup for resonant inelastic soft X-ray scattering on liquids at free electron laser light sources. Rev. Sci. Instrum. 83(12), 123,109 (2012). https://doi.org/10.1063/1.4772685
Marschall, F., Yin, Z., Rehanek, J., Beye, M., Döring, F., Kubiček, K., Raiser, D., Veedu, S.T., Buck, J., Rothkirch, A., Rösner, B., Guzenko, V.A., Viefhaus, J., David, C., Techert, S.: Transmission zone plates as analyzers for efficient parallel 2d RIXS-mapping. Sci. Rep. 7(1) (2017). https://doi.org/10.1038/s41598-017-09052-0
Rajkovic, I., Grübel, S., Quevedo, W., Techert, S.: Ultrafast pump/probe diffraction and spectroscopy experiments with FEL radiation: setup development from the soft to the hard X-rays with the aim of studying chemical processes. In: Tschentscher, T., Cocco, D. (eds.) Advances in X-ray Free-electron Lasers: Radiation Schemes, X-ray Optics, and Instrumentation. SPIE (2011). https://doi.org/10.1117/12.886763
Rajkovic, I., Hallmann, J., Grübel, S., More, R., Quevedo, W., Petri, M., Techert, S.: Development of a multipurpose vacuum chamber for serial optical and diffraction experiments with free-electron laser radiation. Rev. Sci. Instrum. 81(4), 045,105 (2010). https://doi.org/10.1063/1.3327816
Rajkovic, I., Hallmann, J., Grübel, S., More, R., Quevedo, W., Petri, M., Techert, S.: Development of a multipurpose vacuum chamber for serial optical and diffraction experiments with free- electron laser radiation. Virtual J. Ultrafast X-ray Sci. 9(1), 5 (2010). https://doi.org/10.1063/1.3327816
Techert, S.: Choreografie der moleküle—röntgenblitze “filmen” molekulare schalter. MPIbpC News 5, 1–3 (2010)
Techert, S.: Capturing the structural dynamics of biomolecules with X-ray photon-in/photon-out techniques. MPIbpC News 1, 1–4 (2011)
Wernet, P., Kunnus, K., Schreck, S., Quevedo, W., Kurian, R., Techert, S., de Groot, F.M.F., Odelius, M., Föhlisch, A.: Dissecting local atomic and intermolecular interactions of transition-metal ions in solution with selective X-ray spectroscopy. J. Phys. Chem. Lett. 3(23), 3448–3453 (2012). https://doi.org/10.1021/jz301486u
Yin, Z.: X–ray spectroscopy of complex chemical systems in liquid phase (2016)
Yin, Z., Löchel, H., Rehanek, J., Goy, C., Kalinin, A., Schottelius, A., Trinter, F., Miedema, P., Jain, A., Valerio, J., Busse, P., Lehmkühler, F., Möller, J., Grübel, G., Madsen, A., Viefhaus, J., Grisenti, R.E., Beye, M., Erko, A., Techert, S.: X-ray spectroscopy with variable line spacing based on reflection zone plate optics. Opt. Lett. 43(18), 4390 (2018). https://doi.org/10.1364/ol.43.004390
Yin, Z., Peters, H.B., Hahn, U., Agåker, M., Hage, A., Reininger, R., Siewert, F., Nordgren, J., Viefhaus, J., Techert, S.: A new compact soft X-ray spectrometer for resonant inelastic X-ray scattering studies at PETRA III. Rev. Sci. Instrum. 86(9), 093,109 (2015). https://doi.org/10.1063/1.4930968
Yin, Z., Peters, H.B., Hahn, U., Gonschior, J., Mierwaldt, D., Rajkovic, I., Viefhaus, J., Jooss, C., Techert, S.: An endstation for resonant inelastic X-ray scattering studies of solid and liquid samples. J. Synchrotron Radiat. 24(1), 302–306 (2017). https://doi.org/10.1107/s1600577516016611
Yin, Z., Rajković, I., Raiser, D., Scholz, M., Techert, S.: Experimental setup for high resolution X-ray spectroscopy of solids and liquid samples. In: Klisnick, A., Menoni, C.S. (eds.) X-Ray Lasers and Coherent X-Ray Sources: Development and Applications X. SPIE (2013). https://doi.org/10.1117/12.2023992
Yin, Z., Rehanek, J., Löchel, H., Braig, C., Buck, J., Firsov, A., Viefhaus, J., Erko, A., Techert, S.: Highly efficient soft X-ray spectrometer based on a reflection zone plate for resonant inelastic X-ray scattering measurements. Opt. Express 25(10), 10,984 (2017). https://doi.org/10.1364/oe.25.010984
Kunnus, K., Josefsson, I., Rajkovic, I., Schreck, S., Quevedo, W., Beye, M., Grübel, S., Scholz, M., Nordlund, D., Zhang, W., Hartsock, R., Gaffney, K.J., Schlotter, W.F., Turner, J.J., Kennedy, B., Hennies, F., Techert, S., Wernet, P., Odelius, M., Föhlisch, A.: Anti-stokes resonant X-ray raman scattering for atom specific and excited state selective dynamics. New J. Phys. 18(10), 103,011 (2016). https://doi.org/10.1088/1367-2630/18/10/103011
Kunnus, K., Josefsson, I., Rajkovic, I., Schreck, S., Quevedo, W., Beye, M., Weniger, C., Grübel, S., Scholz, M., Nordlund, D., Zhang, W., Hartsock, R.W., Gaffney, K.J., Schlotter, W.F., Turner, J.J., Kennedy, B., Hennies, F., de Groot, F.M.F., Techert, S., Odelius, M., Wernet, P., Föhlisch, A.: Identification of the dominant photochemical pathways and mechanistic insights to the ultrafast ligand exchange of fe(CO)5 to fe(CO)4etoh. Struct. Dyn. 3(4), 043,204 (2016). https://doi.org/10.1063/1.4941602
Wernet, P., Kunnus, K., Josefsson, I., Rajkovic, I., Quevedo, W., Beye, M., Schreck, S., Grübel, S., Scholz, M., Nordlund, D., Zhang, W., Hartsock, R.W., Schlotter, W.F., Turner, J.J., Kennedy, B., Hennies, F., de Groot, F.M.F., Gaffney, K.J., Techert, S., Odelius, M., Föhlisch, A.: Orbital-specific mapping of the ligand exchange dynamics of fe(CO)5 in solution. Nature 520(7545), 78–81 (2015). https://doi.org/10.1038/nature14296
Yin, Z., Quevedo, W., Rajkovic, I., Wernet, P., Föhlisch, A., Pietsch, A., Techert, S.: Ionic solutions probed by resonant inelastic X-ray scattering. Zeitschrift für Physikalische Chem. 1(1), 100–120 (2015). https://doi.org/10.1515/zpch-2015-0610
Debnarova, A.: Ab-initio studies of chemical reactions under intense X-ray radiation (2009)
Debnarova, A., Techert, S., Schmatz, S.: Ab initio studies of ultrafast X-ray scattering of the photodissociation of iodine. J. Chem. Phys. 133(12), 124,309 (2010). https://doi.org/10.1063/1.3475567
Debnarova, A., Techert, S., Schmatz, S.: Computational studies of the X-ray scattering properties of laser aligned stilbene. J. Chem. Phys. 134(5), 054,302 (2011). https://doi.org/10.1063/1.3523569
Kjaer, K.S., Zhang, W., Alonso-Mori, R., Bergmann, U., Chollet, M., Hadt, R.G., Hartsock, R.W., Harlang, T., Kroll, T., Kubicek, K., Lemke, H.T., Liang, H.W., Liu, Y., Nielsen, M.M., Robinson, J.S., Solomon, E.I., Sokaras, D., van Driel, T.B., Weng, T.C., Zhu, D., Persson, P., Warnmark, K., Sundström, V., Gaffney, K.J.: Ligand manipulation of charge transfer excited state relaxation and spin crossover in [fe(2,2\(\prime \)-bipyridine)2(CN)2]. Struct. Dyn. 4(4), 044,030 (2017). https://doi.org/10.1063/1.4985017
Neutze, R., Wouts, R., Techert, S., Kirrander, A., Davidson, J., Kocsis, M., Schotte, F., Wulff, M.: Visualising photo-chemical dynamics in solution through picosecond X-ray scattering. Phys. Rev. Lett. 87(4), 195,508–195,512 (2001). https://doi.org/10.1103/PhysRevLett.86.2030
Petrov, N.K., Gulakov, M.N., Alfimov, M.V., Busse, G., Techert, S.: Solvation-shell effect on the cyanine-dye fluorescence in binary liquid mixtures. Zeitschrift für Physikalische Chem. 221(4), 537–547 (2007). https://doi.org/10.1524/zpch.2007.221.4.537
Techert, S., Neutze, R.: Ultrafast photochemistry, pp. 133–139. TESLA Technical Design Report (2001)
Zhang, W., Kjær, K.S., Alonso-Mori, R., Bergmann, U., Chollet, M., Fredin, L.A., Hadt, R.G., Hartsock, R.W., Harlang, T., Kroll, T., Kubicek, K., Lemke, H.T., Liang, H.W., Liu, Y., Nielsen, M.M., Persson, P., Robinson, J.S., Solomon, E.I., Sun, Z., Sokaras, D., van Driel, T.B., Weng, T.C., Zhu, D., Warnmark, K., Sundstrom, V., Gaffney, K.J.: Tracking excited-state charge and spin dynamics in iron coordination complexes. Nature 509(7500), 345–348 (2014). https://doi.org/10.1038/nature13252
Zhang, W., Kjær, K.S., Alonso-Mori, R., Bergmann, U., Chollet, M., Fredin, L.A., Hadt, R.G., Hartsock, R.W., Harlang, T., Kroll, T., Kubicek, K., Lemke, H.T., Liang, H.W., Liu, Y., Nielsen, M.M., Persson, P., Robinson, J.S., Solomon, E.I., Sun, Z., Sokaras, D., van Driel, T.B., Weng, T.C., Zhu, D., Warnmark, K., Sundstrom, V., Gaffney, K.J.: Manipulating charge transfer excited state relaxation and spin crossover in iron coordination complexes with ligand substitution. Chem. Sci. 8(1), 515–523 (2017). https://doi.org/10.1039/c6sc03070j
Debnarova, A., Techert, S., Schmatz, S.: Limitations of high-intensity soft x-ray laser fields for the characterisation of water chemistry: Coulomb explosion of the octamer water cluster. Phys. Chem. Chem. Phys. 14(27), 9606 (2012). https://doi.org/10.1039/c2cp40598a
Jay, R.M., Norell, J., Eckert, S., Hantschmann, M., Beye, M., Kennedy, B., Quevedo, W., Schlotter, W.F., Dakovski, G.L., Minitti, M.P., Hoffmann, M.C., Mitra, A., Moeller, S.P., Nordlund, D., Zhang, W.W.W.L., Kunnus, K., Kubicek, K., Techert, S.A., Lundberg, M., Wernet, P., Gaffney, K., Odelius, M., Föhlisch, A.: Disentangling transient charge density and metal–ligand covalency in photoexcited ferricyanide with femtosecond resonant inelastic soft X-ray scattering. J. Phys. Chem. Lett. 9(12), 3538–3543 (2018). https://doi.org/10.1021/acs.jpclett.8b01429
Kunnus, K., Josefsson, I., Schreck, S., Quevedo, W., Miedema, P.S., Techert, S., de Groot, F.M.F., Föhlisch, A., Odelius, M., Wernet, P.: Quantifying covalent interactions with resonant inelastic soft x-ray scattering: case study of Ni2 aqua complex. Chem. Phys. Lett. 669, 196–201 (2017). https://doi.org/10.1016/j.cplett.2016.12.046
Mitzner, R., Rehanek, J., Kern, J., Gul, S., Hattne, J., Taguchi, T., Alonso-Mori, R., Tran, R., Weniger, C., Schröder, H., Quevedo, W.H.L., Sierra, R.G., Han, G., Lassalle-Kaiser, B., Koroidov, S., Kubicek, K., Schreck, S., Kunnus, K., Brzhezinskaya, M., Firsov, A., Minitti, M.P., Turner, J.J., Moeller, S., Sauter, N.K., Bogan, M.J., Nordlund, D.W.F.S., Messinger, J., Borovik, A., Techert, S., de Groot, F.M.F., Föhlisch, A., Erko, A.U.B., Yachandra, V.K., Wernet, P., Yano, J.: L-edge x-ray absorption spectroscopy of dilute systems relevant to metalloproteins using an x-ray free-electron laser. J. Phys. Chem. Lett. 4(21), 3641–3647 (2013). https://doi.org/10.1021/jz401837f
Petri, M.: Time-resolved structure determination in low-periodic systems (2011)
Petri, M., Busse, G., Quevedo, W., Techert, S.: Photo-induced phase transitions to liquid crystal phases: influence of the chain length from c8e4 to c14e4. Materials 2(3), 1305–1322 (2009). https://doi.org/10.3390/ma2031305
Petri, M., Menzel, A., Bunk, O., Busse, G., Techert, S.: Concentration effects on the dynamics of liquid crystalline self-assembly: time-resolved x-ray scattering studies. J. Phys. Chem. A 115(11), 2176–2183 (2011). https://doi.org/10.1021/jp1108224
Quevedo, W.: Time-resolved investigations in liquid crystals and periodic nanostructures (2010)
Quevedo, W., Peth, C., Busse, G., Mann, K., Techert, S.: Nanosecond dynamics of photoexcited lyotropic liquid crystal structures. J. Phys. Chem. B 114(26), 8593–8599 (2010). https://doi.org/10.1021/jp101609q
Quevedo, W., Peth, C., Busse, G., Scholz, M., Mann, K., Techert, S.: Time-resolved soft x-ray diffraction reveals transient structural distortions of ternary liquid crystals. Int. J. Mol. Sci. 10(11), 4754–4771 (2009). https://doi.org/10.3390/ijms10114754
Quevedo, W., Petri, M., Busse, G., Techert, S.: On the mechanism of photoinduced phase transitions in ternary liquid crystal systems near thermal equilibrium. J. Chem. Phys. 129(2), 024,502 (2008). https://doi.org/10.1063/1.2943200
Quevedo, W., Petri, M., Techert, S.: Home-based time-resolved photo small angle x-ray diffraction and its applications. Zeitschrift für Kristallographie 223(4-5/2008) (2008). https://doi.org/10.1524/zkri.2008.0031
Ramos, A.S.F., Techert, S.: Influence of the water structure on the acetylcholinesterase efficiency. Biophys. J. 89(3), 1990–2003 (2005). https://doi.org/10.1529/biophysj.104.055798
Ramos, A.S.F., Techert, S.: Determination of the relative permittivity of acetylcholinesterase. J. Phys. Chem. Lett. 1(1), 417–419 (2009). https://doi.org/10.1021/jz900261z
Schreck, S., Beye, M., Sellberg, J.A., McQueen, T., Laksmono, H., Kennedy, B., Eckert, S., Schlesinger, D., Nordlund, D., Ogasawara, H., Sierra, R.G., Segtnan, V., Kubicek, K., Schlotter, W.F., Dakovski, G.L., Moeller, S., Bergmann, U., Techert, S., Pettersson, L., Wernet, P., Bogan, M.J., Harada, Y., Nilsson, A., Föhlisch, A.: Reabsorption of soft X-ray emission at high X-ray free-electron laser fluences. Phys. Rev. Lett. 113(15) (2014). https://doi.org/10.1103/physrevlett.113.153002
Schreck, S., Pietzsch, A., Kennedy, B., Såthe, C., Miedema, P.S., Techert, S., Strocov, V.N., Schmitt, T., Hennies, F., Rubensson, J.E., Föhlisch, A.: Ground state potential energy surfaces around selected atoms from resonant inelastic X-ray scattering. Sci. Rep. 7, 20,054 (2016). https://doi.org/10.1038/srep20054
Sellberg, J.A., McQueen, T.A., Laksmono, H., Schreck, S., Beye, M., DePonte, D.P., Kennedy, B., Nordlund, D., Sierra, R.G., Schlesinger, D., Tokushima, T., Zhovtobriukh, I., Eckert, S., Segtnan, V.H., Ogasawara, H., Kubicek, K., Techert, S., Bergmann, U., Dakovski, G.L., Schlotter, W.F., Harada, Y., Bogan, M.J., Wernet, P., Föhlisch, A., Pettersson, L.G.M., Nilsson, A.: X-ray emission spectroscopy of bulk liquid water in “no-man’s land”. J. Chem. Phys. 142(4), 044,505 (2015). https://doi.org/10.1063/1.4905603
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Techert, S., Thekku Veedu, S., Bari, S. (2020). Development of Ultrafast X-ray Free Electron Laser Tools in (Bio)Chemical Research. In: Salditt, T., Egner, A., Luke, D.R. (eds) Nanoscale Photonic Imaging. Topics in Applied Physics, vol 134. Springer, Cham. https://doi.org/10.1007/978-3-030-34413-9_17
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