Abstract
Linear scar is a common problem in all fields of surgery as it leads to unpleasant appearance that is not socially acceptable. In particular, linear scars in the exposed areas such as face, neck, and upper extremities cause significant psychological disturbance to patients who need proper medical assistance to release their suffering. The author proposed tissue remodeling strategy on an existed linear scar using FMRT (fractional microplasma radiofrequency technology) to render gross view of a linear scar less visible or non-visible by changing the scar tissue architecture. Similar concept is also applied to the intervention of an early-stage wound to significantly alter the natural process of wound healing via FMRT-mediated change of the histological architecture of a wound, and thus to prevent the formation of a grossly visible linear scar. This chapter introduces the general background information, FMRT concept, and its application on linear scar treatment and prevention with the presentation of several typical cases.
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Keywords
- Wound/scar remodeling
- FMRT (fractional microplasma radiofrequency technology)
- Early-stage wound intervention
- Scar prevention
1 Introduction
A strategy of remodeling of an existed scar is by changing its tissue architecture that can eventually lead to a grossly non-visible or minimally visible scar. Since some years, mechanical or energetic manipulation of scarred skin has received considerable attention in attempts to improve scar quality. Next to techniques as dermabrasia, CO2 laser, or microneedling, microplasma technology might represent a new technique in this field [1].
1.1 Fractional Microplasma Radiofrequency Technology
There are four formats of matter: solid, liquid, gas, and plasma. With energy, solid can be converted into liquid and liquid into gas. Similarly, gas can also be transformed into plasma with energy input. The fractional microplasma radiofrequency technology (FMRT) employs the energy of radiofrequency to act on nitrogen of the air in the narrow space between the therapy tip and the treated skin, and thus to form a grid of high-energy focal-led plasma sparks, which result in ionization of a portion of the atoms. With this physical effect, the FMRT can cause mild ablation of the epidermis with the formation of micro-channels in a fractional way (◘ Fig. 53.1).
The device we used in the past 13 years for patient treatment was a product from Alma Lasers (Caesarea, Israel) called PixelRF with both roller and stationary tips. ◘ Figure 53.1 demonstrates its working mechanism of the device. In general, this device creates the depth of ablative point in 100–150 μm, and the size of ablative point 80–120 μm in diameter, and heating effect with a unipolar can reach the depth of 1000 μm, depending on the radiofrequency power and pulse duration. However, the ablative depth could reach to the upper part of the dermis with increasing energy, and thus to remodel a superficial layer of dermis. By this way, the FMRT can remodel tissue structure via ablative microchannel of epidermis and controlled thermal modification of the underlying dermis, with new collagen synthesis and collagen remodeling [2, 3]. With this type of working mechanism, the created micropore wound can be healed in 7 days (◘ Fig. 53.2) and thus repeated treatments can be applied.
Although this particular device was used because of its availability to the author at that time, the effect of wound/scar remodeling is also likely to be achieved by other devices such as CO2 fractional laser or others made by Lumenis, Cynosure, Alma, or Syneron, depending on physicians’ clinical expertise (◘ Fig. 53.3).
2 Procedures: Clinical Protocol for Microplasma-Based Tissue Remodeling (◘ Fig. 53.3)
2.1 Pre-therapy Preparation
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Patients with skin lesions at the treating area should be advised not to receive the treatment before the cure of these lesions, including infectious skin lesions caused by both virus and bacteria, dermatitis, psoriasis, eczema, and urticaria.
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Patients should be advised for proper management of the micropore wound post-therapy and potential side effects with signed written informed consent.
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Photography before the treatment. Be sure that it is taken before topical anesthesia and it is in the same conditions of environment such as light, focus, and positions.
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Topical application of 5% lidocaine hydrochloric gel under plastic wrap for 60–90 minutes before the treatment followed by thorough cleaning and sterilization with 70% alcohol.
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Non-treated skin should be protected with paper tape surrounding the treated skin if the tip is larger than the area to be treated.
2.2 Microplasma Treatment
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Fractional microplasma radiofrequency treatment was performed with the device of Pixel RF (Alma Lasers, Caesarea, Israel).
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A roller tip was used with the power setting at 60–90 watts, and 3–4 passes were usually made in different directions.
2.3 Post-therapy Wound Care
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Patients are advised for comprehensive instructions of post-procedure care.
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Sterile saline cleaning and erythromycin eye ointment were topically applied daily for 6 days to prevent infection.
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Patients are advised not to be exposed to sunlight to avoid post-therapy pigmentation.
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Patients are advised to protect the treating area by avoiding scratching or rubbing.
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Patients are advised to have the follow-up regularly.
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In the case of early wound remodeling, anti-tension type or device should be applied before and after the treatment.
3 Application Areas for FMRT-Mediated Tissue Remodeling
3.1 Microplasma Therapy for Post-scar Revision Skin to Enhance Cosmetic Result
Brief descriptions of the procedures for treating a linear scar for cosmetic reasons are as follows:
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In general, a patient will visit our clinics and seek a consultation through discussing what a patient is expected and what can be achieved from the procedures. Then the patient will make an appointment for a scar revision surgical procedure.
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In the surgical procedure, the patient is given a local injection of 1–2% lidocaine for anesthesia. In most cases, a w-plasty procedure will be applied along with the surgical excision of a linear scar to prevent linear tension, which usually causes observable scarring after the scar revision. To reduce wound tension, wound edge flap should be freed before wound closure. In addition, suturing of wound tissue at various levels also helps reducing wound tension, including subcutaneous, dermal, and epidermal tissues. For patients who are prone to scarring, wound irrigation with triamcinolone acetonide (5 mg/mL) or 5-fluorouracil (2–4 mg/mL) or both combined should be applied before wound closure to prevent scar formation.
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After the surgical procedure, tension-reduction tape (such as 3 M tape) should be applied to keep the wound in a tension-free state. Patients are advised to have the tape changed every 2–3 days and maintained for at least 6 months post-surgery. The stiches are removed at day 5 or 6 post-surgery for head and neck regions, and stich removal can be postponed for 1 or 2 days at other regions. In case of the scar-prone patients who were treated for hypertrophic scar or keloid, an injection of triamcinolone acetonide (5 mg/mL) or 5-fluorouracil (2–4 mg/mL) or both combined with lidocaine into the healed wound can be administered at 1 or 2 months post-suturing.
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In most cases, Pixel RF microplasma is applied to the healed incisional wound at 8 weeks post-surgery. Generally, the therapy should include 2–3 mm normal skin on both sides of the linear wound. The procedure is usually applied with a roller tip at 60–70 watts with 3–4 passes (◘ Fig. 53.2).
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Pixel RF microplasma therapy should be repeated for 3–5 times with 8–12 weeks’ interval in general and patients should be closely followed up every 4–8 weeks until a linear wound mark and stich marks are completely removed. By this procedure, the linear scar resulting from scar revision procedure can be largely removed and the fine linear scar becomes grossly less visible or non-visible.
The following are the case presentations.
Case 1
A 32-year–old female patient visited our clinic to request for forehead scar treatment solely for cosmetic reason. Physical examination showed a red-colored linear scar with a length of 2 cm and a width of 0.2 cm. In addition, the linear scar was also a bit elevated and with a few stich marks scar on both sides (◘ Fig. 53.4a). The patient received a scar revision surgery along with w-plasty procedure. After the surgery, the patient wore 3 M anti-tension paper tape vertical to the incision line. Later, silicone gel was also applied topically on the incisional line, and then 3 M paper was used. At 8 weeks post-surgery, she received microplasma therapy with an energy of 65 watts and 4–6 passes of rolling therapy. At 8 weeks after the first treatment, the follow-up photo showed significant improvement of the gross view of her forehead scar, although a fine linear scar remains when observed closely (◘ Fig. 53.4b). Then, the patient received another two treatments with 8 weeks’ interval between them. At 8 weeks after the third therapy, the follow-up photo shows no visible linear scar on her head (◘ Fig. 53.4c), and the patient was completely satisfied as the result match her original request of removing her forehead scar completely.
Case 2
A 27-year-old female patient visited our clinic for cosmetic treatment of a linear scar on her left face. Physical examination showed a mature flatten linear scar with a length of 6 cm and a width of 0.5 cm as shown in ◘ Fig. 53.5a. The patient received a surgery of scar revision plus w-plasty. The follow-up photo at 8 weeks post-surgery showed an apparent linear scar resulting from scar surgical revision, with which the patient was significantly unsatisfied despite the fact that an original wide and flatten scar has been transformed into a fine linear scar (◘ Fig. 53.5b). At this time point, microplasma tissue remodeling procedure was applied to the patient with an energy of 70 watts and six passes using a roller tip. Interestingly, at 8 weeks after the first therapy, the linear scar has already been significantly remodeled with the previous linear scar obscured; however, the linear scar remained obviously visible (◘ Fig. 53.5c). Thereafter, the patient was given another two microplasma therapies with 8 weeks’ interval between them. At 8 weeks after the third therapy, the follow-up photo showed that a linear scar resulting from scar revision surgery was almost completely remodeled with no apparently visible linear scar (◘ Fig. 53.5d). Due to the thorough tissue remodeling process, in which the tissue structure of a healed linear wound has been significantly changed along with a regenerative skin repair, angiogenesis apparently occurred with manifestation of skin redness (◘ Fig. 53.5d), which will disappear in 3–6 months after the discontinuation of the treatment. The patient was very satisfied with the end result, in which microplasma tissue remodeling played a role significantly more important than the surgical procedure.
3.2 Microplasma for Early Wound Intervention to Prevent Scar Formation
With the success of remodeling healed linear wound tissue, we wondered if such a concept could be applied to tissue remodeling of an early incisional wound to prevent scar formation. The scenario is that linear wounds of non-elected surgical procedures such as trauma and wounding are usually difficult to prepare an optimal condition for their healing, and thus these linear wounds are more likely to form an obvious linear scar than the wounds created by elected surgical procedure of scar revision.
Due to the non-optimal healing condition, the wound tissue remodeling procedure should be applied at an early-stage wound. In addition, improvement of wound healing conditions by other wound manipulation methods should also be applied comprehensively including anti-tension, silicone product, drug local injection, or even re-suturing of an already sutured wound. Following are the general principles:
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When a patient with an acute linear skin wound visits the clinic, proper wound cleaning should be the first consideration. In case of severe wounds or appearance of early signs of wound infection, antibiotics should be applied either locally or systemically or both.
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Anti-tension tape or device should be applied before and after stich removal, such as 3 M tape, Zipline™ or Neodyne™ or other tension reduction device in order to maximally reduce the tension-induced scarring during wound healing process.
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Silicone product should be applied as early as possible, such as Dermatix™, Kelo-cote™ or other products. This should be applied along with taping or tension-reduction device and wound tension-free procedure should not be compromised by other procedures.
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Proper surgical procedures for wound closing is important as a thick scar will be too difficult to be remodeled for achieving a desirable effect. When decided to perform, proper debridement, wound edge preparation as well as fine suturing should all be included.
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The timing for microplasma procedure can be decided on the basis of the wound condition. If an injured wound is properly managed with a condition similar to that of elected surgical procedure, the remodeling procedure can be performed at time point about 8 weeks post-wound closure to give a wound sufficient time to heal as a very fine linear immature scar, which can be completely remodeled with microplasma procedure. If a wound is improperly closed with a thick linear wound mark and obvious other stich marks, then the procedure should be applied as early as 1–4 weeks post-wound closure.
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The energy of microplasma remodeling can be adjusted according to the wound condition. For example, a wound of a child or a wound with fine closure technique, then the wound can be treated with a relative low energy; whereas a wound is closed unprofessionally or in a poor condition, a relatively high energy should be applied and the treatment should be repeated until a desirable result can be achieved.
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The comprehensive scar-reduction management should be continually applied after the remodeling and maintained for at least for 6 months post-wound closure.
The following are the case presentations.
Case 3
A 52-year-old male (◘ Fig. 53.6) was wounded on his left-side face 3 days before, and he came to our clinic for assistance of the wound management in order to prevent severe scarring. Physical examination showed that there was a linear wound on his left-side face with a length of 3 cm. The wound had been closed unprofessionally by single layer suturing with tight knots that would be bound to form a thick linear scar with obvious stich marks after the healing of the wound (◘ Fig. 53.6a). To better prepare the wound closure, the stiches were removed and the wound was re-opened. After thorough wound debridement, wound dermal and epidermal layers were properly positioned and closed with fine suturing (◘ Fig. 53.6b). The stiches were removed at day 5 post-surgery and 3 M tape was applied. At 4 weeks post-surgery (31 days after wounding), the patient received his first microplasma remodeling. Eight weeks later (87 days after wounding), the follow-up photo showed significant improved gross view of the healed linear wound (◘ Fig. 53.6c). Then the patient was given the second microplasma remodeling. Eight weeks later (143 day after wounding), the patient was followed up with a photo demonstrating that linear wound mark was almost all removed via tissue remodeling (◘ Fig. 53.6d). The patient was very satisfied with the wound remodeling result.
Case 4
A 11-year-old female was injured on her left-side face and part of nose 5 days before she visited our clinic. She had concern of possible scar formation on her face after wound healing. Physical examination showed that there was a linear scar on her left-side face starting from suborbital region and extending to the left part of the upper region of the nose. In addition, she also had a curved linear wound at the left side of her left ala nasi as shown in ◘ Fig. 53.7a. The patient was asked to remove her stiches and to apply 3 M tape for anti-tension purpose. The patient was given COX-2 inhibitor (oral medicine) for 2 weeks to reduce wound inflammatory process. At day 12 post-wounding, there was an early sign of scar formation as raised tissue was observed on the upper wound of her face (arrow, ◘ Fig. 53.7b). The patient was thus given an injection of low concentration steroid to inhibit potential scar formation. Four weeks later, several more injections were given with 4 weeks’ interval between them. During the time period, taping and silicone gel were consistently applied. At 3.5 months post-wounding, the patient was given the first microplasma remodeling. Eight weeks after the first therapy (5.5 months post-wounding), the scarring was significantly remodeled with obvious improvement of the gross view as shown in ◘ Fig. 53.7c. Afterward, the patient was given three more procedures of microplasma remodeling. The final follow-up photo demonstrated that original scar was barely visible except for minor pigmentation. The patient was extremely satisfied with the results.
3.3 Microplasma Remodeling for an Existing Linear Scar
As described previously, scar revision surgery along with microplasma tissue remodeling is a preferred procedure to deal with the significant linear scars in majority cases. However, direct remodeling with microplasma is also a choice for linear scars under certain conditions. These include (1) a superficial linear scar; (2) an irregular shaped linear scar that is difficult to revise with surgical procedure; (3) a linear scar that formed in not too long time; and (4) the scar contains less dense collagen. These linear scars are more likely to be remodeled than other types of linear scars.
The following is a case presentation:
Case 5
A 35-year–old female patient had an irregular linear scar caused by trauma in less than 1 year on the region between forehead and nose (◘ Fig. 53.8a). The linear scar was relatively irregular and superficial and was a bit raised above the skin. Microplasma remodeling procedure was applied using a roller tip with 70 watts for 4–6 passes. ◘ Figure 53.8 shows the tissue remodeling results after the first (◘ Fig. 53.8b), third (◘ Fig. 53.8c), and fourth (◘ Fig. 53.8d) microplasma treatments, which demonstrated gradual improvement of the gross view of the linear scar, and the scar was barely detectable at the end of the treatment. The patient was very happy with the end result.
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Liu, W. (2020). Emerging Technologies in Scar Management: Remodeling of Post-surgical Linear Scar Using Microplasma Radiofrequency. In: Téot, L., Mustoe, T.A., Middelkoop, E., Gauglitz, G.G. (eds) Textbook on Scar Management. Springer, Cham. https://doi.org/10.1007/978-3-030-44766-3_53
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