Abstract
Plasma cell neoplasms including multiple myeloma (MM) and related terminally differentiated B-cell neoplasms are characterized by secretion of monoclonal immunoglobulin and stepwise development from a preneoplastic clonal B and/or plasma cell proliferation called monoclonal gammopathy of undetermined significance (MGUS). Diagnosis of these disorders requires integration of clinical, laboratory, and morphological features. While their classification mostly remains unchanged compared to the revised 2016 WHO classification and the 2014 International Myeloma Working Group consensus, some changes in criteria and terminology were proposed in the 2022 International Consensus Classification (ICC) of mature lymphoid neoplasms. MGUS of IgM type is now divided into IgM MGUS of plasma cell type, precursor to the rare IgM MM and characterized by MM-type cytogenetics, lack of clonal B-cells and absence of MYD88 mutation, and IgM MGUS, NOS including the remaining cases. Primary cold agglutinin disease is recognized as a new entity. MM is now formally subdivided into cytogenetic groups, recognizing the importance of genetics for clinical features and prognosis. MM with recurrent genetic abnormalities includes MM with CCND family translocations, MM with MAF family translocations, MM with NSD2 translocation, and MM with hyperdiploidy, with the remaining cases classified as MM, NOS. For diagnosis of localized plasma cell tumors, solitary plasmacytoma of bone, and primary extraosseous plasmacytoma, the importance of excluding minimal bone marrow infiltration by flow cytometry is emphasized. Primary systemic amyloidosis is renamed immunoglobulin light chain amyloidosis (AL), and a localized AL amyloidosis is recognized as a distinct entity. This review summarizes the updates on plasma cell neoplasms and related entities proposed in the 2022 ICC.
Key points
• Lymphoplasmacytic lymphoma can be diagnosed with lymphoplasmacytic aggregates in trephine biopsies < 10% of cellularity and evidence of clonal B-cells and plasma cells.
• IgM MGUS is subdivided into a plasma cell type and a not otherwise specified (NOS) type.
• Primary cold agglutinin disease is recognized as a new entity.
• The term “multiple myeloma” replaces the term “plasma cell myeloma” used in the 2016 WHO classification.
• Multiple myeloma is subdivided into 4 mutually exclusive cytogenetic groups and MM NOS.
• Minimal bone marrow infiltration detected by flow cytometry is of major prognostic importance for solitary plasmacytoma of bone and to a lesser extent for primary extraosseous plasmacytoma.
• Localized IG light chain amyloidosis is recognized as a separate entity, distinct from systemic immunoglobulin light chain (AL) amyloidosis.
Similar content being viewed by others
Avoid common mistakes on your manuscript.
Introduction
Plasma cell neoplasms and related entities are derived from terminally differentiated B-cells and characterized by secretion of a monoclonal immunoglobulin in most cases. These disorders share their stepwise evolution from the preneoplastic precursor lesion termed monoclonal gammopathy of unknown significance (MGUS) and the common presence of symptoms and complications related to excess quantities of clonal immunoglobulins or their abnormal deposition in tissues. Given the specific disease features due to the abnormal clonotypic immunoglobulin, which can be detected as a serum biomarker at the preclinical level, the classification of these neoplasms requires the integration of clinical and laboratory features for staging and therapy decisions. The changes proposed in the 2022 International Consensus Classification of Mature Lymphoid Neoplasms are mostly minor and relate both to issues of terminology and to more precise disease definitions and refined diagnostic criteria. The recognition of the major importance of primary genetic alterations resulted in the formal subdivision of multiple myeloma into cytogenetic groups [13]. This article briefly summarizes the current diagnostic criteria for these disorders and describes the updates proposed in the 2022 ICC.
IgM MGUS
The diagnosis of IgM monoclonal gammopathy of undetermined significance (IgM MGUS) is established in cases of IgM paraprotein with < 10% bone marrow clonal plasma cells and lacking lymphoplasmacytic B-cell aggregates sufficient for a diagnosis of LPL. While most cases of IgM MGUS represent potential precursors to LPL or other B-cell neoplasms [35], the rare cases of IgM MM [14, 47] are also presumed to develop through an MGUS precursor stage. In an effort to better identify the rare cases that may progress to multiple myeloma, the ICC [13] recognizes two subtypes of IgM MGUS (Fig. 1). IgM MGUS of plasma cell type is defined as those cases demonstrating t(11;14)(q13;q32) or other cytogenetic abnormalities typical of MM, or as clonal plasma cells without a detectable B-cell component and with wild-type MYD88 (Fig. 2). All remaining cases should be diagnosed as IgM MGUS, not otherwise specified (NOS). The category of IgM MGUS, NOS therefore includes all cases with a MYD88 mutation, those with detectable monotypic/monoclonal B-cells but without abnormal lymphoplasmacytic aggregates diagnostic of LPL or other overt small B-cell neoplasm, and cases lacking a detectable plasma cell or lymphoid component. Routine fluorescence in situ hybridization (FISH) studies on enriched plasma cells and MYD88 mutation analysis are recommended in the evaluation of IgM monoclonal gammopathies in order to distinguish between these two IgM MGUS subsets.
Lymphoplasmacytic lymphoma
Lymphoplasmacytic lymphoma (LPL) is defined as a neoplasm of small B-cells, plasmacytoid lymphocytes, and plasma cells that does not meet diagnostic criteria for any other recognized small B-cell neoplasm. LPL typically involves the bone marrow, and there may be involvement of lymph nodes, spleen, and peripheral blood, and occasionally extranodal sites. In most cases, LPL is associated with the secretion of a monoclonal IgM paraprotein (i.e., Waldenstrom’s macroglobulinemia (WM)), which is defined as an IgM paraprotein at any concentration associated with LPL involving the bone marrow. A minority of LPL express IgG or IgA rather than IgM, and this finding does not alter the pathologic diagnosis.
Bone marrow aspirate smears characteristically show increased small lymphocytes, plasmacytoid cells, and plasma cells, often associated with increased numbers of mast cells. In trephine biopsies, LPL shows infiltrates of lymphoplasmacytic cells which may show nodular, interstitial, diffuse, or paratrabecular growth patterns. In the 2016 WHO classification [70], abnormal lymphoplasmacytic infiltrates were required to represent at least 10% of the bone marrow to establish a diagnosis of LPL. This requirement stood in contrast to the longstanding International Workshop on Waldenstrom’s Macroglobulinemia definition of LPL/WM [57], which allowed for recognition of LPL involving < 10% of bone marrow cellularity. To resolve these discrepant definitions, the ICC, following extensive discussion, determined that a diagnosis of LPL may be rendered in cases with abnormal lymphoplasmacytic aggregates in the bone marrow and evidence of clonal B-cells and plasma cells, even when the aggregates represent < 10% of cellularity of the trephine biopsy. It is recognized that some cases will remain diagnostically challenging. In such cases, when it is unclear whether lymphoid aggregates are reactive rather than neoplastic, a diagnosis of IgM MGUS may be most appropriate. In lymph nodes, the most classic cases display partial preservation of lymph node architecture with patent sinuses and a diffuse infiltrate of monotonous small lymphocytes with mature chromatin and scant cytoplasm. Plasmacytoid lymphocytes and plasma cells are present, typically representing a minority of the cellularity, and Dutcher bodies are typically present. Less commonly, cases may show more complete architectural effacement, sometimes with vague nodularity or even follicular colonization.
LPL displays a non-specific phenotype that overlaps with that of other entities, especially marginal zone lymphoma. LPL is typically negative for CD5, CD10, and CD23 although CD5 and CD23 may be expressed in a subset of cases. CD25 and CD38 expressions are frequently present. Unlike multiple myeloma, the plasma cells of LPL are typically positive for CD19 and negative for CD56. While studies to date are limited, IRTA1 expression, seen in a subset of cases of marginal zone lymphomas, appears to be rare in LPL [23, 74]. CD180 expression has also been reported to favor a diagnosis of marginal zone lymphoma over LPL [53, 55].
Molecular studies for MYD88 and CXCR4 mutations are strongly encouraged in the workup of suspected LPL. MYD88 mutations in the TIR domain are found in > 90% of LPL predominantly L265P, although rarely non-L265P variants may be present [28, 72]. Molecular studies for MYD88 L265P should be performed using a sensitive method as some sequencing methods may yield false negative results, especially in cases with low tumor volume [18]. A small percentage of LPL are MYD88 wild-type with alternative mutations downstream of MYD88 in the NFKB signaling pathway. The CAC debated the question of whether a MYD88 mutation should be required for the diagnosis of LPL, but the consensus conclusion was that there is insufficient evidence to support the classification of MYD88 wild-type cases as a distinct entity. Therefore, although neither present in 100% of cases nor not specific for LPL, the presence of MYD88 L265P mutations assists in the diagnosis of LPL in the appropriate clinicopathologic context, especially as this variant is only seen in a small percentage of marginal zone lymphomas. CXCR4 mutations are identified in up to 40% of LPL, and, particularly, the non-sense variants have been associated with symptomatic hyperviscosity and resistance to ibrutinib therapy [15, 72]. Of note, the molecular techniques employed should be of sufficient sensitivity to detect MYD88 and CXCR4 mutations down to the 1–2% level, such as allele-specific PCR, digital droplet PCR, or highly sensitive NGS-based approaches [31].
Primary cold agglutinin disease
Primary cold agglutinin disease (pCAD) is recognized as a new diagnostic category, distinct from LPL or IgM MGUS. pCAD is defined as an indolent bone marrow–based lymphoproliferative disorder associated with the production of a cold agglutinin monoclonal antibody [4, 5, 61]. The monoclonal antibody is typical of the IgM isotype with the utilization of the IGHV4-34 variable region and recognition of the I blood group antigen. Notably, cases of CAD associated with nodal involvement by an overt lymphoma should be considered secondary CAD and are excluded from this category. Similarly, the presence of splenomegaly suggests a diagnosis of splenic marginal zone lymphoma or other splenic lymphomas with secondary CAD rather than a diagnosis of pCAD.
Morphologically, bone marrow findings in pCAD are variable. Most cases are reported to show an infiltrate of small lymphocytes in aggregates or nodules with median infiltration of 10% of intermedullary space [61]. A minority of cases may show only scattered B-cells and plasma cells. Prominent plasmacytoid lymphocytes and increased mast cells, typical of LPL, are reported to be absent.
Using immunohistochemistry and flow cytometry, the B-cells are light chain restricted with the expression of CD20, PAX5, CD79b, and FMC7 [61]. A minority of cases are reported to be positive for CD5. The B-cells are negative for CD10, BCL6, and cyclin D1. Light chain–restricted plasma cells are also found. pCAD lacks the MYD88 L265P mutation found in LPL [49, 50, 61], a feature which greatly facilitates appropriate diagnosis. Cytogenetic studies and chromosomal microarray studies have shown that trisomies of chromosomes 3, 12, and 18 are highly recurrent in pCAD [49]. Next-generation sequencing studies have identified recurrent mutations in KMT2D and CARD11 [50]. These molecular cytogenetic results have suggested that pCAD may be more closely related to marginal zone lymphomas rather than LPL, but there is insufficient evidence of support for the classification of pCAD as a definitive marginal zone lymphoma subtype at this time.
Plasma cell neoplasms
Plasma cell neoplasms are derived from terminally differentiated B-cells, and plasma cells without a B-cell component constitute the dominant and proliferating cell population, which sets them apart from lymphoplasmacytic lymphoma and other mature B-cell lymphomas, many of which can show maturation to plasma cells to a varying degree [54]. Three groups of disorders can be discerned based on their clinical presentation: (1) multiple myeloma (MM) (previously plasma cell myeloma [58]), the most common disease, characterized by diffuse bone marrow infiltration and diverse manifestations of organ damage; (2) localized plasma cell tumors, namely solitary plasmacytoma of bone (SPB) and primary extraosseous/extramedullary plasmacytoma (EMP), which lack significant bone marrow infiltration; and (3) disorders primarily characterized by the consequences of abnormal immunoglobulin deposition, namely immunoglobulin light chain amyloidosis and non-amyloid light and/or heavy chain immunoglobulin deposition diseases [54]. The presence of a clonal immunoglobulin of non-IgM type, including light chains only, in the absence of diagnostic criteria for one of the above disorders is called non-IgM MGUS, which is considered a virtually universal precursor lesion to MM [35, 75]. Although MGUS is considered a preclinical precursor lesion in asymptomatic individuals, secreted clonal immunoglobulin may cause clinical symptoms and require treatment as described below. Of practical importance, plasma cell neoplasms require the integration of clinical and laboratory parameters, as well as morphology and immunophenotype and cytogenetics to reach a final diagnosis for clinical management. The 2014 IMWG consensus criteria adopted by the revised 2016 WHO classification and the 2022 ICC are summarized in Table 1 [13, 60, 70].
Non-IgM MGUS
The diagnosis of non-IgM MGUS is established in the presence of a minor clonal plasma proliferation in the bone marrow associated with the secretion of a paraprotein of non-IgM type or a single light chain as defined by the International Myeloma Working Group (IMWG) in 2014 and adopted in the ICC 2022 [13, 60]. In brief, the criteria include less than 10% clonal plasma cells in the BM, serum monoclonal protein (non-IgM type) < 30 g/L, or abnormal free light ratio (< 0.26 or > 1.65) and urinary monoclonal protein < 500 mg/24 h in light chain MGUS (approximately 20% of cases), absence of myeloma-defining end-organ damage such as hyperCalcaemia, Renal insufficiency, Anemia, and Bone lesions (so-called CRAB criteria), or amyloidosis that can be attributed to the plasma cell clone. If a clonal bone marrow plasma cell proliferation not fulfilling MM criteria is accompanied by systemic AL amyloid deposition, a diagnosis of immunoglobulin light chain amyloidosis (AL) is rendered. Of note, detection of amyloid in the setting of MGUS or MM does not equal a diagnosis of immunoglobulin light chain amyloidosis (AL) and requires amyloid subtyping, since occasionally other types of amyloid may be found (e.g., ATTR amyloidosis). Non-IgM MGUS is common and affects approximately 3–4% of individuals > 50 years. The average rate of transformation to MM is around 1% per year [35, 36]. As mentioned above, a small subset of IgM MGUS is considered myeloma-type, lacking a B lymphocyte component and MYD88 mutation. The role of pathology in non-IgM MGUS lies in the quantification of plasma cells in the bone marrow and the demonstration of light chain restriction and aberrant marker expression by immunophenotyping. Of note, cases of non-IgM MGUS with a low load of clonal plasma cells frequently lack a demonstrable light chain restriction by immunohistochemistry or in situ hybridization.
Paraneoplastic syndromes associated with plasma cell neoplasms
M-protein produced by the neoplastic plasma cells of MGUS may cause a variety of clinical symptoms not fulfilling diagnostic criteria for MM, but nevertheless may require therapeutic intervention. Renal damage due to toxic immunoglobulin light chains is common in plasma cell neoplasms. Light chain cast nephropathy is a MM-defining CRAB criterion, since most cases fulfill the tumor burden requirements for an MM diagnosis. In addition, renal light chain amyloid deposits lead to a diagnosis of immunoglobulin light chain amyloidosis (AL). However, other forms of kidney damage caused by direct or indirect effects of the monoclonal immunoglobulin do not result in a diagnosis of MM or another B-cell neoplasm, if no other criteria are present. Since these patients nevertheless may require treatment, the term monoclonal gammopathy of renal significance (MGRS) has been coined [42]. In most instances, renal damage is due to the specific properties of the secreted immunoglobulin, which may either result in abnormal deposits in the glomeruli or proximal tubules, crystal formation or activation of complement with glomerular inflammation, or thrombotic microangiopathy [41,42,43]. In addition to renal impairment, a broad range of extrarenal symptoms caused by the clonal immunoglobulin have been described in the setting of early-stage plasma cell or B-cell neoplasia, and an extension of the concept of MGRS has recently been developed to include extrarenal symptoms and complications caused by the clonal immunoglobulin, termed monoclonal gammopathy of clinical significance (MGCS) [24]. In addition to the effects of Ig deposition, disorders caused by autoantibody activity, complement activation, or cytokine secretion of the neoplastic clone are included. Of note, both MGRS and MGCS include disorders with underlying IgM MGUS as well as non-IgM MGUS. Despite their clinical importance, MGRS and MGCS are not considered separate disease entities in the ICC classification [13], which is centered on the malignancy rather than accompanying paraneoplastic syndromes and separates IgM MGUS and non-IgM MGUS on biological and genetic grounds. However, the terms MGRS and MGCS can be added as a clinical descriptor, since the presence of clinically relevant disease caused by the monoclonal immunoglobulin may indicate the use of therapeutic agents aimed at the neoplastic clone, which would otherwise not be justified by the tumor load.
Two specific paraneoplastic syndromes associated with a clonal plasma cell proliferation are POEMS syndrome and TEMPI syndrome. POEMS syndrome is characterized by a clonal plasma cell neoplasm, frequently osteosclerotic multiple myeloma, and, in 11–30% of cases, lymph node changes of multicentric plasma cell variant of Castleman disease. POEMS stands for polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin lesions [20]. Other common features include extravascular fluid overload with effusions, papilledema, lung disease, and markedly elevated levels of vascular endothelial growth factor (VEGF). Most patients (90–95%) show an M-protein with lambda light chains [19]. The bone marrow exhibits a lambda-restricted plasma cell population with concomitant increased polytypic plasma cells, lymphoid aggregates rimmed by plasma cells, and megakaryocyte hyperplasia [17]. TEMPI syndrome (telangiectasias, elevated erythropoietin level and erythrocytosis, monoclonal gammopathy, perinephric fluid collections, and intrapulmonary shunting) is a rare paraneoplastic syndrome associated with MGUS or MM, which may be confused with polycythemia vera due to erythrocytosis caused be extremely elevated erythropoietin levels [71]. The bone marrow in these patients shows significant erythroid hyperplasia without the features of a myeloproliferative neoplasm and a clonal plasma cell population mostly at MGUS levels [63].
A rare, unusual feature of MM is crystal-storing histiocytosis, a reactive hyperplasia of macrophages containing abundant crystallized IG inclusions of kappa light chain type, which may be confused with a storage disorder and is occasionally also observed in other B-cell neoplasms secreting a clonal IG [29, 39].
Smoldering multiple myeloma (SMM)
SMM is a clinically asymptomatic disease stage, which was traditionally handled with a wait-and-see approach [37]. SMM shows a higher tumor load than MGUS, with serum monoclonal protein (IgG or IgA) ≥ 30 g/L or urinary monoclonal protein ≥ 500 mg/24 h and/or clonal bone marrow plasma cells 10–60%, but lacks features for symptomatic MM including the so-called SLiM-CRAB criteria following the updated IMWG definitions [60]. The so-called SLiM criteria added in the 2014 IMWG consensus moved some cases previously designated SMM into the active MM category including the sixty % cutoff for bone marrow plasma cells, a light chain ratio of kappa to lambda > 100, and more than 1 focal lesion on magnetic resonance imaging (MRI). Recent years have shown that the progression risk of SMM, overall about 10%/year and thus tenfold higher than for MGUS, varies widely [37]. Whereas about 50% and 30% of SMM patients do not progress to symptomatic disease within 5 and 10 years, respectively, some patients with SMM have a high progression risk and might benefit from early treatment to avoid the complications of manifest MM. The progression risk can be estimated by conventional clinical and laboratory features, but the addition of cytogenetic and molecular features described below allows for a refined stratification of patients with smoldering MM [9,10,11, 38, 52]. The CAC therefore strongly recommended using established risk models for stratification of SMM to identify patients requiring therapy without yet fulfilling criteria for symptomatic MM [38, 52].
Multiple myeloma
Multiple myeloma is one of the most common hematological neoplasms and constitutes about 1% of all human cancers. Manifest or symptomatic MM is diagnosed in patients fulfilling any of the SLiM-CRAB criteria according to the 2014 IMWG consensus as described above and in Table 1. From the diagnostic viewpoint, this means that differentiating between smoldering and manifest MM requires the integration of clinical data, unless the plasma cell infiltrate exceeds 60% of BM cellularity. The plasma cell percentage should be assessed both cytologically on BM aspirates and in the BM trephine, with the higher number taken for diagnosis. Although most cases of MM are easily identifiable on routine stains, cases with lymphoplasmacytic morphology, frequently associated with CD20 expression, anaplastic MM, and cases with unusual cytoplasmic inclusions due to disturbances in IG secretion may cause diagnostic difficulties (Fig. 3). For exact quantification in the BM trephine, it is advised to use immunostaining for plasma cell markers such as CD38, which is also the target for the therapeutic antibody daratumumab and can be downregulated following treatment, CD138 or MUM1, since tumor cell counts especially in cases with small cell or lymphoplasmacytic morphology and interstitial infiltration may be underestimated in routine stains. Of note, CD138 may be weak in some MM cases and is also expressed by a variety of epithelial tumors and may result in misinterpretation, especially in conjunction with CD56 expression. In addition to showing light chain restriction, immunostains and flow cytometric immunophenotyping can demonstrate an aberrant plasma cell phenotype, such as expression of CD56, CD117, or cyclin D1 and loss of CD19. Strongly and homogeneously expressed cyclin D1 can serve as an indicator for the t(11;14) translocation and is associated with lymphoplasmacytic morphology and concomitant expression of CD20 and other B-cell markers usually absent from MM cells in about half the cases, providing a potential diagnostic pitfall [46, 69]. CD56 is expressed in approximately 70–80% of MM, with a lower incidence in t(11;14) + MM and IgM + MM, and can be downregulated in secondary extramedullary spread, especially in plasma cell leukemia.
Specific subtypes of MM
Some subtypes of MM show specific clinical and/or biological features, which deserve special mention. Most MM secrete a complete or incomplete (light chains (LC) only) monoclonal immunoglobulin (IgG > LC > IgA > > IgM, IgD, IgE), but a very small subset of non-secretory MM lacks a detectable M-protein in blood or urine, even if very sensitive tests such as the free light chain ratio are used. This phenomenon can be due to either lack of secretion or lack of production of the clonal IG. Patients with non-secretory MM show a distinct clinical profile with the absence of M-protein-induced organ damage, such as renal insufficiency, and lower levels of immunoparesis [22, 45].
IgD + MM is a rare disease subtype (1–2% of MM) derived from preclass switched B-cells and more frequently shows a t(11;14) translocation. Although previously considered to exhibit more aggressive behavior overall, survival is comparable to other MM subtypes with modern therapies [1, 44].
Plasma cell leukemia (PCL), which can arise as primary (60–70%) or less frequently as secondary (30–40%) PCL, is an aggressive form of MM with sometimes acute onset and poor prognosis. According to the recently published consensus of the IMWG, the threshold of circulating plasma cells for a diagnosis of PCL was lowered from ≥ 20 to ≥ 5%, given the similarly poor prognosis of patients fulfilling these new criteria [25].
Genetic subclassification of MM
MM shows a significant genetic heterogeneity, which has been recognized in the last decades. Two main groups are defined by cytogenetics, namely recurrent IGH translocations with a variety of partners in 40–50% of cases and up to 55% lacking recurrent translocations but exhibiting hyperdiploidy, with infrequent cases not falling into either group [6, 26, 27]. These cytogenetic features are already present in MGUS and thus represent primary alterations [21, 30]. They persist throughout the disease course and are strongly correlated with clinical and phenotypic features, prognosis, therapy response, and the gene expression profile [58, 64, 73, 76]. Therefore, the 2022 ICC proposes to formally subdivide MM into 2 mutually exclusive groups, namely (1) MM NOS and (2) MM with recurrent genetic abnormalities including MM with CCND family translocations, MM with MAF family translocation, MM with NSD2 translocation, and MM with hyperdiploidy, characterized by trisomies of uneven chromosomes (3, 5, 7, 9, 11, 15, 19, and 21) (Table 2) [13]. Of note, these genetic groups are also of importance for risk stratification models of MM, which incorporate the high-risk t(4;14) and t(14;16) translocations and also secondary high-risk alterations such as del(17p), amp1q, and del(1p) [58, 68]. The current standard for the detection of these cytogenetic aberrations is interphase fluorescence in situ hybridization (FISH), and minimal and comprehensive FISH panels for the evaluation of MM have been published [16, 58]. At primary diagnosis including smoldering MM, FISH should be performed at least for the t(4;14) and t(14;16) translocations, for alterations of chromosome 1 (+ 1q, -1p) and -17p, usually complemented by the t(11;14) and odd-numbered chromosomes for detection of hyperdiploidy. These alterations may also be detected more comprehensively with gene expression profiling (GEP) or WGS. GEP has also been used to refine prognostication by defining risk scores such as the GEP70 or the EMC92 [34, 67].
The role of mutational profiling in MM, which shows a very heterogeneous molecular landscape, remains to be determined in future studies, but mutational analysis of TP53 is recommended for relapsed MM [40, 51, 59]. Of note, the mutational profile is predetermined by the primary cytogenetic alterations, pointing to an oncogenic interdependence of primary and secondary genetic alterations with non-random clonal evolution [73]. A factor potentially complicating risk prediction and therapy planning is the significant spatial heterogeneity with the development of subclones restricted to focal lesions as demonstrated by profiling of multiple lesions from individual MM patients [62]. Another important feature of the malignant plasma cells in MM is the interaction with and dependence on the bone marrow microenvironment, which gradually diminishes over the course of the illness and finally can result in extramedullary extension of disease and secondary plasma cell leukemia [65].
Localized plasma cell neoplasms
Two forms of localized plasma cell neoplasms are recognized: solitary plasmacytoma of bone (SBP) and primary extraosseous/extramedullary plasmacytoma (EMP) [70]. Both are characterized by tumor-forming accumulations of clonal plasma cells with the absence of manifest bone marrow infiltration by definition. SBP accounts for about 4–5% of all plasma cell neoplasms and lacks MM-defining criteria or clonal bone marrow plasma cells > 10% [12, 56]. Solitary EMP comprises only 1–3% of plasma cell malignancies and usually presents at mostly extranodal sites, frequently in the head and neck region. A special variant of EMP with IgA expression predominantly manifests in lymph nodes of the head and neck region, frequently in younger patients with various forms of immune dysregulation [66]. Both SBP and EMP are characterized by monotonous proliferations of mostly mature plasma cells with light chain restriction (Fig. 4). For EMP, the presence of an accompanying neoplastic B-cell population raises the differential diagnosis of an extranodal marginal zone lymphoma (Table 3). Since amyloid deposition frequently accompanies EMP, a Congo red stain should be included in the workup. Phenotypically, EMP, SBP, and MM are very similar, but EMP shows less frequent expression of CD56, usually absence of cyclin D1 (and the t(11;14) translocation), and a lower proliferation rate as compared to extramedullary manifestations of multiple myeloma, which usually represent an aggressive terminal stage of disease and may show high MYC expression and TP53 aberrations [33]. Extramedullary MM and rarely EMP may show plasmablastic cytology with large nuclei with open chromatin and prominent eosinophilic central nucleoli and high nuclear-cytoplasmic ratio, which raises a differential diagnosis of plasmablastic lymphoma. Table 3 summarizes the criteria for the distinction of B-cell neoplasms with plasmacytic/plasmablastic differentiation. Although data are limited, EMP shows MM-type cytogenetics with recurrent IGH translocations and polysomies, emphasizing a close relationship to MM [7, 8]. Progression to MM occurs in approximately 15% of EMP cases [2, 8, 12, 33, 56]. The risk for progression to MM overall is higher for SBP (60–85% after 10 years) than for EMP (12–35% after 10 years), but it has been shown that the presence of a minimal infiltrate of clonal plasma cells in the BM detected by flow cytometry is associated with a strongly increased progression risk, although the risk remains lower for EMP. The 3-year progression rate to MM is about 60% for SBP with the presence of clonal BM plasma cells versus 6–12% without, and approximately 20% for EMP with and 6% without BM plasma cells. The CAC therefore strongly recommended including the absence or presence of minimal BM infiltration into the diagnosis and using flow cytometry for staging in every localized plasma cell neoplasm. Due to the rarity of these disorders, the prognostic impact of cytogenetic or other molecular alterations is currently unknown.
Immunoglobulin light chain (AL) amyloidosis
The CAC recommended changing the name of primary amyloidosis to immunoglobulin light chain (AL) amyloidosis to clearly separate it from other forms of amyloid deposition disease, as well as from non-amyloid-forming deposition of clonal immunoglobulin in the light chain and heavy chain deposition diseases, but the diagnostic criteria otherwise remain unchanged (Table 1) [13]. A rare, clinically mostly indolent plasma cell disorder is localized light chain (AL) amyloidosis. Localized AL amyloidosis, also called amyloid tumor or amyloidoma, is characterized by tumor-forming deposits of AL amyloid (lambda light chains in 50–75%) with frequent foreign body-type giant cell reaction in the absence of systemic disease or a manifest, i.e., tumor-forming accompanying B-cell or plasma cell neoplasm (Table 1) [3, 32, 48]. Localized AL amyloidosis may be accompanied by a sparse infiltrate of B-cells and plasma cells with clonality detected by immunohistochemistry or in situ hybridization for IG light chains (Fig. 5), or by PCR for clonal IG rearrangements in about 30% and a small serum M-protein in about 20% of cases, depending on case selection criteria. The most commonly affected organs are the urinary tract, lung, upper respiratory tract, skin, and the GI tract, but virtually any organ can be affected. Local progression is common, but several large retrospective series have demonstrated that progression to systemic IG light chain amyloidosis is very rare (< 2%), and complications, if any, usually arise from local tumor growth potentially requiring surgical intervention [3, 32, 48]. The CAC therefore recommended recognizing localized light chain amyloidosis as a distinct entity in order to separate it from systemic immunoglobulin light chain (AL) amyloidosis, which carries a much graver prognosis and requires systemic therapy [13].
References
Agbuduwe C, Iqbal G, Cairns D, Menzies T, Dunn J, Gregory W, Kaiser M, Owen R, Pawlyn C, Child JA, Davies F, Morgan GJ, Jackson GH, Drayson MT, Basu S (2022) Clinical characteristics and outcomes of IgD myeloma: experience across UK national trials. Blood Adv 6:5113–5123. https://doi.org/10.1182/bloodadvances.2022007608
Alexiou C, Kau RJ, Dietzfelbinger H, Kremer M, Spiess JC, Schratzenstaller B, Arnold W (1999) Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. Cancer 85:2305–2314
Basset M, Hummedah K, Kimmich C, Veelken K, Dittrich T, Brandelik S, Kreuter M, Hassel J, Bosch N, Stuhlmann-Laeisz C, Blank N, Muller-Tidow C, Rocken C, Hegenbart U, Schonland S (2020) Localized immunoglobulin light chain amyloidosis: novel insights including prognostic factors for local progression. Am J Hematol 95:1158–69. https://doi.org/10.1002/ajh.25915
Berentsen S, Barcellini W, D’Sa S, Randen U, Tvedt THA, Fattizzo B, Haukas E, Kell M, Brudevold R, Dahm AEA, Dalgaard J, Froen H, Hallstensen RF, Jaeger PH, Hjorth-Hansen H, Malecka A, Oksman M, Rolke J, Sekhar M, Sorbo JH, Tjonnfjord E, Tsykunova G, Tjonnfjord GE (2020) Cold agglutinin disease revisited: a multinational, observational study of 232 patients. Blood 136:480–488. https://doi.org/10.1182/blood.2020005674
Berentsen S, Malecka A, Randen U, Tjonnfjord GE (2020) Cold agglutinin disease: where do we stand, and where are we going? Clin Adv Hematol Oncol 18:35–44
Bergsagel PL, Kuehl WM (2005) Molecular pathogenesis and a consequent classification of multiple myeloma. J Clin Oncol 23:6333–6338
Bink K, Haralambieva E, Kremer M, Ott G, Beham-Schmid C, de Leval L, Peh SC, Laeng HR, Jutting U, Hutzler P, Quintanilla-Martinez L, Fend F (2008) Primary extramedullary plasmacytoma: similarities with and differences from multiple myeloma revealed by interphase cytogenetics. Haematologica 93:623–626. https://doi.org/10.3324/haematol.12005
Boll M, Parkins E, O’Connor SJ, Rawstron AC, Owen RG (2010) Extramedullary plasmacytoma are characterized by a ‘myeloma-like’ immunophenotype and genotype and occult bone marrow involvement. Br J Haematol 151:525–527. https://doi.org/10.1111/j.1365-2141.2010.08386
Boyle EM, Deshpande S, Tytarenko R, Ashby C, Wang Y, Bauer MA, Johnson SK, Wardell CP, Thanendrarajan S, Zangari M, Facon T, Dumontet C, Barlogie B, Arbini A, Rustad EH, Maura F, Landgren O, Zhan F, van Rhee F, Schinke C, Davies FE, Morgan GJ, Walker BA (2021) The molecular make up of smoldering myeloma highlights the evolutionary pathways leading to multiple myeloma. Nat Commun 12:293. https://doi.org/10.1038/s41467-41020-20524-41462
Bustoros M, Anand S, Sklavenitis-Pistofidis R, Redd R, Boyle EM, Zhitomirsky B, Dunford AJ, Tai YT, Chavda SJ, Boehner C, Neuse CJ, Rahmat M, Dutta A, Casneuf T, Verona R, Kastritis E, Trippa L, Stewart C, Walker BA, Davies FE, Dimopoulos MA, Bergsagel PL, Yong K, Morgan GJ, Aguet F, Getz G, Ghobrial IM (2022) Genetic subtypes of smoldering multiple myeloma are associated with distinct pathogenic phenotypes and clinical outcomes. Nat Commun 13:3449. https://doi.org/10.1038/s41467-41022-30694-w
Bustoros M, Sklavenitis-Pistofidis R, Park J, Redd R, Zhitomirsky B, Dunford AJ, Salem K, Tai YT, Anand S, Mouhieddine TH, Chavda SJ, Boehner C, Elagina L, Neuse CJ, Cha J, Rahmat M, Taylor-Weiner A, Van Allen E, Kumar S, Kastritis E, Leshchiner I, Morgan EA, Laubach J, Casneuf T, Richardson P, Munshi NC, Anderson KC, Trippa L, Aguet F, Stewart C, Dimopoulos MA, Yong K, Bergsagel PL, Manier S, Getz G, Ghobrial IM (2020) Genomic profiling of smoldering multiple myeloma identifies patients at a high risk of disease progression. J Clin Oncol 38:2380–2389. https://doi.org/10.1200/JCO.2320.00437
Caers J, Paiva B, Zamagni E, Leleu X, Blade J, Kristinsson SY, Touzeau C, Abildgaard N, Terpos E, Heusschen R, Ocio E, Delforge M, Sezer O, Beksac M, Ludwig H, Merlini G, Moreau P, Zweegman S, Engelhardt M, Rosinol L (2018) Diagnosis, treatment, and response assessment in solitary plasmacytoma: updated recommendations from a European Expert Panel. J Hematol Oncol 11:10. https://doi.org/10.1186/s13045-017-0549-1
Campo E, Jaffe ES, Cook JR, Quintanilla-Martinez L, Swerdlow SH, Anderson KC, Brousset P, Cerroni L, de Leval L, Dirnhofer S, Dogan A, Feldman A, Fend F, Friedberg JW, Gaulard P, Ghia P, Horwitz SM, King RL, Salles GA, San-Miguel JF, Seymour JF, Treon SP, Vose J, Zucca E, Advani R, Ansell SM, Au WY, Barrionuevo C, Bergsagel PL, Chan WC, Cohen JI, d’Amore F, Davies AJ, Falini B, Ghobrial IM, Goodlad JR, Gribben JG, Hsi ED, Kahl BS, Kim WS, Kumar SK, LaCasce AS, Laurent C, Lenz G, Leonard JP, Link MP, López-Guillermo A, Mateos MV, Macintyre EA, Melnick AM, Morschhauser F, Nakamura S, Narbaitz M, Pavlovsky A, Pileri SA, Piris MA, Pro B, Rajkumar SVV, Rosen ST, Sander B, Sehn LH, Shipp MA, Smith SM, Staudt LM, Thieblemont C, Tousseyn T, Wilson WH, Yoshino T, Zinzani PL, Dreyling M, Scott DW, Winter JN, Zelenetz AD (2022) The International Consensus Classification of Mature Lymphoid Neoplasms: a report from the Clinical Advisory Committee. Blood 140:1229–1253. https://doi.org/10.1182/blood.2022015851
Castillo JJ, Jurczyszyn A, Brozova L, Crusoe E, Czepiel J, Davila J, Dispenzieri A, Eveillard M, Fiala MA, Ghobrial IM, Gozzetti A, Gustine JN, Hajek R, Hungria V, Jarkovsky J, Jayabalan D, Laubach JP, Lewicka B, Maisnar V, Manasanch EE, Moreau P, Morgan EA, Nahi H, Niesvizky R, Paba-Prada C, Pika T, Pour L, Reagan JL, Richardson PG, Shah J, Spicka I, Vij R, Waszczuk-Gajda A, Gertz MA (2017) IgM myeloma: a multicenter retrospective study of 134 patients. Am J Hematol 92:746–751. https://doi.org/10.1002/ajh.24753
Castillo JJ, Moreno DF, Arbelaez MI, Hunter ZR, Treon SP (2019) CXCR4 mutations affect presentation and outcomes in patients with Waldenstrom macroglobulinemia: a systematic review. Expert Rev Hematol 12:873–881. https://doi.org/10.1080/17474086.2019.1649132
Chng WJ, Huang GF, Chung TH, Ng SB, Gonzalez-Paz N, Troska-Price T, Mulligan G, Chesi M, Bergsagel PL, Fonseca R (2011) Clinical and biological implications of MYC activation: a common difference between MGUS and newly diagnosed multiple myeloma. Leukemia 25:1026–1035. https://doi.org/10.1038/leu.2011.53
Dao LN, Hanson CA, Dispenzieri A, Morice WG, Kurtin PJ, Hoyer JD (2011) Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood 117:6438–6444. https://doi.org/10.1182/blood-2010-11-316935
de Leval L, Alizadeh AA, Bergsagel PL, Campo E, Davies AJ, Dogan A, Fitzgibbon J, Horwitz SM, Melnick AM, Morice WG, Morin RD, Nadel B, Pileri SA, Rosenquist R, Rossi D, Salaverria I, Steidl C, Treon SP, Zelenetz AD, Advani R, Allen CE, Ansell SM, Chan WC, Cook JR, Cook LB, d’Amore F, Dirnhofer S, Dreyling M, Dunleavy K, Feldman A, Fend F, Gaulard P, Ghia P, Gribben JG, Hermine O, Hodson DJ, Hsi ED, Inghirami GG, Jaffe ES, Karube K, Kataoka K, Klapper W, Kim WS, King RL, Ko YH, LaCasce AS, Lenz G, Martin-Subero I, Piris MA, Pittaluga S, Pasqualucci L, Quintanilla-Martinez L, Rodig SJ, Rosenwald A, Salles GA, San-Miguel J, Savage KJ, Sehn LH, Semenzato G, Staudt LM, Swerdlow SH, Tam CS, Trotman J, Vose J, Weigert O, Wilson WH, Winter JN, Wu CJ, Zinzani PL, Zucca E, Bagg A, Scott DWW (2022) Genomic profiling for clinical decision making in lymphoid neoplasms. Blood. https://doi.org/10.1182/blood.2022015854
Dispenzieri A (2014) POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. Am J Hematol 89:214–223. https://doi.org/10.1002/ajh.23644
Dispenzieri A (2021) POEMS syndrome: 2021 update on diagnosis, risk-stratification, and management. Am J Hematol 96:872–888. https://doi.org/10.1002/ajh.26240
Drach J, Angerler J, Schuster J, Rothermundt C, Thalhammer R, Haas OA, Jager U, Fiegl M, Geissler K, Ludwig H, Huber H (1995) Interphase fluorescence in situ hybridization identifies chromosomal abnormalities in plasma cells from patients with monoclonal gammopathy of undetermined significance. Blood 86:3915–3921
Dupuis MM, Tuchman SA (2016) Non-secretory multiple myeloma: from biology to clinical management. Onco Targets Ther 9:7583–7590. https://doi.org/10.2147/OTT.S122241
Falini B, Agostinelli C, Bigerna B, Pucciarini A, Pacini R, Tabarrini A, Falcinelli F, Piccioli M, Paulli M, Gambacorta M, Ponzoni M, Tiacci E, Ascani S, Martelli MP, Dalla Favera R, Stein H, Pileri SA (2012) IRTA1 is selectively expressed in nodal and extranodal marginal zone lymphomas. Histopathology 61:930–941. https://doi.org/10.1111/j.1365-2559.2012.04289.x
Fermand JP, Bridoux F, Dispenzieri A, Jaccard A, Kyle RA, Leung N, Merlini G (2018) Monoclonal gammopathy of clinical significance: a novel concept with therapeutic implications. Blood 132:1478–1485. https://doi.org/10.1182/blood-2018-1404-839480
Fernandez de Larrea C, Kyle R, Rosinol L, Paiva B, Engelhardt M, Usmani S, Caers J, Gonsalves W, Schjesvold F, Merlini G, Lentzch S, Ocio E, Garderet L, Moreau P, Sonneveld P, Badros A, Gahrton G, Goldschmidt H, Tuchman S, Einsele H, Durie B, Wirk B, Musto P, Hayden P, Kaiser M, Miguel JS, Blade J, Rajkumar SV, Mateos MV (2021) Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage. Blood Cancer J 11:192. https://doi.org/10.1038/s41408-021-00587-0
Fonseca R, Barlogie B, Bataille R, Bastard C, Bergsagel PL, Chesi M, Davies FE, Drach J, Greipp PR, Kirsch IR, Kuehl WM, Hernandez JM, Minvielle S, Pilarski LM, Shaughnessy JD Jr, Stewart AK, Avet-Loiseau H (2004) Genetics and cytogenetics of multiple myeloma: a workshop report. Cancer Res 64:1546–1558
Fonseca R, Bergsagel PL, Drach J, Shaughnessy J, Gutierrez N, Stewart AK, Morgan G, Van Ness B, Chesi M, Minvielle S, Neri A, Barlogie B, Kuehl WM, Liebisch P, Davies F, Chen-Kiang S, Durie BG, Carrasco R, Sezer O, Reiman T, Pilarski L, Avet-Loiseau H (2009) International Myeloma Working Group molecular classification of multiple myeloma: spotlight review. Leukemia 23:2210–2221. https://doi.org/10.1038/leu.2009.174
Hunter ZR, Xu L, Tsakmaklis N, Demos MG, Kofides A, Jimenez C, Chan GG, Chen J, Liu X, Munshi M, Gustine J, Meid K, Patterson CJ, Yang G, Dubeau T, Samur MK, Castillo JJ, Anderson KC, Munshi NC, Treon SP (2018) Insights into the genomic landscape of MYD88 wild-type Waldenstrom macroglobulinemia. Blood Adv 2:2937–2946. https://doi.org/10.1182/bloodadvances.2018022962
Jones D, Bhatia VK, Krausz T, Pinkus GS (1999) Crystal-storing histiocytosis: a disorder occurring in plasmacytic tumors expressing immunoglobulin kappa light chain. Hum Pathol 30:1441–1448
Kaufmann H, Ackermann J, Baldia C, Nosslinger T, Wieser R, Seidl S, Sagaster V, Gisslinger H, Jager U, Pfeilstocker M, Zielinski C, Drach J (2004) Both IGH translocations and chromosome 13q deletions are early events in monoclonal gammopathy of undetermined significance and do not evolve during transition to multiple myeloma. Leukemia 18:1879–1882. https://doi.org/10.1038/sj.leu.2403518
Kofides A, Hunter ZR, Xu L, Tsakmaklis N, Demos MG, Munshi M, Liu X, Guerrera ML, Leventoff CR, White TP, Flynn CA, Meid K, Patterson CJ, Yang G, Branagan AR, Sarosiek S, Castillo JJ, Treon SP, Gustine JN (2021) Diagnostic next-generation sequencing frequently fails to detect MYD88(L265P) in Waldenstrom macroglobulinemia. Hemasphere 5:e624. https://doi.org/10.1097/HS9.0000000000000624
Kourelis TV, Kyle RA, Dingli D, Buadi FK, Kumar SK, Gertz MA, Lacy MQ, Kapoor P, Go RS, Gonsalves WI, Warsame R, Lust JA, Hayman SR, Rajkumar SV, Zeldenrust SR, Russell SJ, Lin Y, Leung N, Dispenzieri A (2017) Presentation and outcomes of localized immunoglobulin light chain amyloidosis: the Mayo Clinic experience. Mayo Clin Proc 92:908–917. https://doi.org/10.1016/j.mayocp.2017.02.016
Kremer M, Ott G, Nathrath M, Specht K, Stecker K, Alexiou C, Quintanilla-Martinez L, Fend F (2005) Primary extramedullary plasmacytoma and multiple myeloma: phenotypic differences revealed by immunohistochemical analysis. J Pathol 205:92–101
Kuiper R, Broyl A, de Knegt Y, van Vliet MH, van Beers EH, van der Holt B, el Jarari L, Mulligan G, Gregory W, Morgan G, Goldschmidt H, Lokhorst HM, van Duin M, Sonneveld P (2012) A gene expression signature for high-risk multiple myeloma. Leukemia 26:2406–2413. https://doi.org/10.1038/leu.2012.127
Kyle RA, Larson DR, Therneau TM, Dispenzieri A, Kumar S, Cerhan JR, Rajkumar SV (2018) Long-term follow-up of monoclonal gammopathy of undetermined significance. N Engl J Med 378:241–249. https://doi.org/10.1056/NEJMoa1709974
Kyle RA, Rajkumar SV (2006) Monoclonal gammopathy of undetermined significance. Br J Haematol 134:573–589. https://doi.org/10.1111/j.1365-2141.2006.06235.x
Kyle RA, Remstein ED, Therneau TM, Dispenzieri A, Kurtin PJ, Hodnefield JM, Larson DR, Plevak MF, Jelinek DF, Fonseca R, Melton LJ 3rd, Rajkumar SV (2007) Clinical course and prognosis of smoldering (asymptomatic) multiple myeloma. N Engl J Med 356:2582–2590. https://doi.org/10.1056/NEJMoa070389
Lakshman A, Rajkumar SV, Buadi FK, Binder M, Gertz MA, Lacy MQ, Dispenzieri A, Dingli D, Fonder AL, Hayman SR, Hobbs MA, Gonsalves WI, Hwa YL, Kapoor P, Leung N, Go RS, Lin Y, Kourelis TV, Warsame R, Lust JA, Russell SJ, Zeldenrust SR, Kyle RA, Kumar SK (2018) Risk stratification of smoldering multiple myeloma incorporating revised IMWG diagnostic criteria. Blood Cancer J 8:59. https://doi.org/10.1038/s41408-41018-40077-41404
Lebeau A, Zeindl-Eberhart E, Muller EC, Muller-Hocker J, Jungblut PR, Emmerich B, Lohrs U (2002) Generalized crystal-storing histiocytosis associated with monoclonal gammopathy: molecular analysis of a disorder with rapid clinical course and review of the literature. Blood 100:1817–1827
Ledergor G, Weiner A, Zada M, Wang SY, Cohen YC, Gatt ME, Snir N, Magen H, Koren-Michowitz M, Herzog-Tzarfati K, Keren-Shaul H, Bornstein C, Rotkopf R, Yofe I, David E, Yellapantula V, Kay S, Salai M, Ben Yehuda D, Nagler A, Shvidel L, Orr-Urtreger A, Halpern KB, Itzkovitz S, Landgren O, San-Miguel J, Paiva B, Keats JJ, Papaemmanuil E, Avivi I, Barbash GI, Tanay A, Amit I (2018) Single cell dissection of plasma cell heterogeneity in symptomatic and asymptomatic myeloma. Nat Med 24:1867–1876. https://doi.org/10.1038/s41591-018-0269-2
Leung N, Bridoux F, Batuman V, Chaidos A, Cockwell P, D’Agati VD, Dispenzieri A, Fervenza FC, Fermand JP, Gibbs S, Gillmore JD, Herrera GA, Jaccard A, Jevremovic D, Kastritis E, Kukreti V, Kyle RA, Lachmann HJ, Larsen CP, Ludwig H, Markowitz GS, Merlini G, Mollee P, Picken MM, Rajkumar VS, Royal V, Sanders PW, Sethi S, Venner CP, Voorhees PM, Wechalekar AD, Weiss BM, Nasr SH (2019) The evaluation of monoclonal gammopathy of renal significance: a consensus report of the International Kidney and Monoclonal Gammopathy Research Group. Nat Rev Nephrol 15:45–59. https://doi.org/10.1038/s41581-41018-40077-41584
Leung N, Bridoux F, Hutchison CA, Nasr SH, Cockwell P, Fermand JP, Dispenzieri A, Song KW, Kyle RA (2012) Monoclonal gammopathy of renal significance: when MGUS is no longer undetermined or insignificant. Blood 120:4292–4295. https://doi.org/10.1182/blood-2012-4207-445304
Leung N, Bridoux F, Nasr SH (2021) Monoclonal gammopathy of renal significance. N Engl J Med 384:1931–1941. https://doi.org/10.1056/NEJMra1810907
Liu J, Hu X, Jia Y, Lu J, Lee JH, Kim K, Chen W, Liu A, Liu Y, Chen Q, Zhang C, Suh C, Kim MK, Zhou F, Chng WJ, Kumar SK, Durie B, Hou J, Fu W, Du J (2021) Clinical features and survival outcomes in IgD myeloma: a study by Asia Myeloma Network (AMN). Leukemia 35:1797–1802. https://doi.org/10.1038/s41375-020-01060-w
Lonial S (2013) Kaufman JL (2013) Non-secretory myeloma: a clinician’s guide. Oncology (Williston Park) 27:924–928
Lorsbach RB, Hsi ED, Dogan A, Fend F (2011) Plasma cell myeloma and related neoplasms. Am J Clin Pathol 136:168–182. https://doi.org/10.1309/AJCPENJ68FFBRIYB
Lu H, Durkin L, Zhao X, Nakashima MO (2022) IgM plasma cell myeloma. Am J Clin Pathol 157:47–53. https://doi.org/10.1093/ajcp/aqab095
Mahmood S, Bridoux F, Venner CP, Sachchithanantham S, Gilbertson JA, Rowczenio D, Wagner T, Sayed R, Patel K, Fontana M, Whelan CJ, Lachmann HJ, Hawkins PN, Gillmore JD, Wechalekar AD (2015) Natural history and outcomes in localised immunoglobulin light-chain amyloidosis: a long-term observational study. Lancet Haematol 2:e241-250. https://doi.org/10.1016/S2352-3026(15)00068-X
Malecka A, Delabie J, Ostlie I, Tierens A, Randen U, Berentsen S, Tjonnfjord GE, Troen G (2020) Cold agglutinin-associated B-cell lymphoproliferative disease shows highly recurrent gains of chromosome 3 and 12 or 18. Blood Adv 4:993–996. https://doi.org/10.1182/bloodadvances.2020001608
Malecka A, Troen G, Tierens A, Ostlie I, Malecki J, Randen U, Wang J, Berentsen S, Tjonnfjord GE, Delabie JMA (2018) Frequent somatic mutations of KMT2D (MLL2) and CARD11 genes in primary cold agglutinin disease. Br J Haematol 183:838–842. https://doi.org/10.1111/bjh.15063
Manier S, Salem KZ, Park J, Landau DA, Getz G, Ghobrial IM (2017) Genomic complexity of multiple myeloma and its clinical implications. Nat Rev Clin Oncol 14:100–113. https://doi.org/10.1038/nrclinonc.2016.122
Mateos MV, Kumar S, Dimopoulos MA, González-Calle V, Kastritis E, Hajek R, De Larrea CF, Morgan GJ, Merlini G, Goldschmidt H, Geraldes C, Gozzetti A, Kyriakou C, Garderet L, Hansson M, Zamagni E, Fantl D, Leleu X, Kim BS, Esteves G, Ludwig H, Usmani S, Min CK, Qi M, Ukropec J, Weiss BM, Rajkumar SV, Durie BGM, San-Miguel J (2020) International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM). Blood Cancer J 10:102. https://doi.org/10.1038/s41408-41020-00366-41403
Mayeur-Rousse C, Guy J, Miguet L, Bouyer S, Genevieve F, Robillard N, Solly F, Maar A, Bene MC, Mauvieux L, Geil, (2016) CD180 expression in B-cell lymphomas: a multicenter GEIL study. Cytometry B Clin Cytom 90:462–466. https://doi.org/10.1002/cyto.b.21325
McKenna RW, Kyle RD, Kuehl WM, Harris NL, Coupland R, Fend F (2017) Plasma cell neoplasms. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri S, Stein H, Thiele J, Arber DA, Hasserjian RP, Le Beau MM, Orazi A, Siebert R (eds) WHO classification of tumours of hematopoietic and lymphoid tissues. IARC, Lyon, pp. 241–253
Miguet L, Lennon S, Baseggio L, Traverse-Glehen A, Berger F, Perrusson N, Chenard MP, Galoisy AC, Eischen A, Mayeur-Rousse C, Maar A, Fornecker L, Herbrecht R, Felman P, Van Dorsselaer A, Carapito C, Cianferani S, Mauvieux L (2013) Cell-surface expression of the TLR homolog CD180 in circulating cells from splenic and nodal marginal zone lymphomas. Leukemia 27:1748–1750. https://doi.org/10.1038/leu.2013.3
Nahi H, Genell A, Walinder G, Uttervall K, Juliusson G, Karin F, Hansson M, Svensson R, Linder O, Carlson K, Bjorkstrand B, Kristinsson SY, Mellqvist UH, Blimark C, Turesson I (2017) Incidence, characteristics, and outcome of solitary plasmacytoma and plasma cell leukemia. Population-based data from the Swedish Myeloma Register. Eur J Haematol 99:216–222. https://doi.org/10.1111/ejh.12907
Owen RG, Treon SP, Al-Katib A, Fonseca R, Greipp PR, McMaster ML, Morra E, Pangalis GA, San Miguel JF, Branagan AR, Dimopoulos MA (2003) Clinicopathological definition of Waldenstrom’s macroglobulinemia: consensus panel recommendations from the Second International Workshop on Waldenstrom’s Macroglobulinemia. Semin Oncol 30:110–115. https://doi.org/10.1053/sonc.2003.50082
Palumbo A, Avet-Loiseau H, Oliva S, Lokhorst HM, Goldschmidt H, Rosinol L, Richardson P, Caltagirone S, Lahuerta JJ, Facon T, Bringhen S, Gay F, Attal M, Passera R, Spencer A, Offidani M, Kumar S, Musto P, Lonial S, Petrucci MT, Orlowski RZ, Zamagni E, Morgan G, Dimopoulos MA, Durie BG, Anderson KC, Sonneveld P, San Miguel J, Cavo M, Rajkumar SV, Moreau P (2015) Revised International Staging System for Multiple Myeloma: a report From International Myeloma Working Group. J Clin Oncol 33:2863–2869. https://doi.org/10.1200/JCO.2015.61.2267
Pawlyn C, Morgan GJ (2017) Evolutionary biology of high-risk multiple myeloma. Nat Rev Cancer 17:543–556. https://doi.org/10.1038/nrc.2017.63
Rajkumar SV, Dimopoulos MA, Palumbo A, Blade J, Merlini G, Mateos MV, Kumar S, Hillengass J, Kastritis E, Richardson P, Landgren O, Paiva B, Dispenzieri A, Weiss B, LeLeu X, Zweegman S, Lonial S, Rosinol L, Zamagni E, Jagannath S, Sezer O, Kristinsson SY, Caers J, Usmani SZ, Lahuerta JJ, Johnsen HE, Beksac M, Cavo M, Goldschmidt H, Terpos E, Kyle RA, Anderson KC, Durie BG, Miguel JF (2014) International Myeloma Working Group updated criteria for the diagnosis of multiple myeloma. Lancet Oncol 15:e538-548. https://doi.org/10.1016/S1470-2045(14)70442-5
Randen U, Troen G, Tierens A, Steen C, Warsame A, Beiske K, Tjonnfjord GE, Berentsen S, Delabie J (2014) Primary cold agglutinin-associated lymphoproliferative disease: a B-cell lymphoma of the bone marrow distinct from lymphoplasmacytic lymphoma. Haematologica 99:497–504. https://doi.org/10.3324/haematol.2013.091702
Rasche L, Chavan SS, Stephens OW, Patel PH, Tytarenko R, Ashby C, Bauer M, Stein C, Deshpande S, Wardell C, Buzder T, Molnar G, Zangari M, van Rhee F, Thanendrarajan S, Schinke C, Epstein J, Davies FE, Walker BA, Meissner T, Barlogie B, Morgan GJ, Weinhold N (2017) Spatial genomic heterogeneity in multiple myeloma revealed by multi-region sequencing. Nat Commun 8:268. https://doi.org/10.1038/s41467-017-00296-y
Rosado FG, Oliveira JL, Sohani AR, Schroyens W, Sykes DB, Kenderian SS, Lacy MQ, Kyle RA, Hoyer JD (2015) Bone marrow findings of the newly described TEMPI syndrome: when erythrocytosis and plasma cell dyscrasia coexist. Mod Pathol 28:367–372. https://doi.org/10.1038/modpathol.2014.117
Schinke C, Hoering A, Wang H, Carlton V, Thanandrarajan S, Deshpande S, Patel P, Molnar G, Susanibar S, Mohan M, Mathur P, Radhakrishnan M, Hoque S, Jo Kamimoto J, Grazziutti M, van Rhee F, Zangari M, Insuasti-Beltran G, Alapat D, Post G, Yaccoby S, Epstein J, Rasche L, Johnson S, Moorhead M, Willis T, Barlogie B, Walker B, Weinhold N, Davies FE, Morgan GJ (2017) The prognostic value of the depth of response in multiple myeloma depends on the time of assessment, risk status and molecular subtype. Haematologica 102:e313–e316. https://doi.org/10.3324/haematol.2017.165217
Schurch CM, Rasche L, Frauenfeld L, Weinhold N, Fend F (2020) A review on tumor heterogeneity and evolution in multiple myeloma: pathological, radiological, molecular genetics, and clinical integration. Virchows Arch 476:337–351. https://doi.org/10.1007/s00428-019-02725-3
Shao H, Xi L, Raffeld M, Pittaluga S, Dunleavy K, Wilson WH, Spector N, Milito C, Morais JC, Jaffe ES (2010) Nodal and extranodal plasmacytomas expressing immunoglobulin a: an indolent lymphoproliferative disorder with a low risk of clinical progression. Am J Surg Pathol 34:1425–1435. https://doi.org/10.1097/PAS.0b013e3181f17d0d
Shaughnessy JD Jr, Zhan F, Burington BE, Huang Y, Colla S, Hanamura I, Stewart JP, Kordsmeier B, Randolph C, Williams DR, Xiao Y, Xu H, Epstein J, Anaissie E, Krishna SG, Cottler-Fox M, Hollmig K, Mohiuddin A, Pineda-Roman M, Tricot G, van Rhee F, Sawyer J, Alsayed Y, Walker R, Zangari M, Crowley J, Barlogie B (2007) A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1. Blood 109:2276–2284. https://doi.org/10.1182/blood-2006-07-038430
Sonneveld P, Avet-Loiseau H, Lonial S, Usmani S, Siegel D, Anderson KC, Chng WJ, Moreau P, Attal M, Kyle RA, Caers J, Hillengass J, San Miguel J, van de Donk NW, Einsele H, Blade J, Durie BG, Goldschmidt H, Mateos MV, Palumbo A, Orlowski R (2016) Treatment of multiple myeloma with high-risk cytogenetics: a consensus of the International Myeloma Working Group. Blood 127:2955–2962. https://doi.org/10.1182/blood-2016-01-631200
Specht K, Haralambieva E, Bink K, Kremer M, Mandl-Weber S, Koch I, Tomer R, Hofler H, Schuuring E, Kluin PM, Fend F, Quintanilla-Martinez L (2004) Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels. Blood 104:1120–1126
Swerdlow SH, Campo E, Pileri SA, Harris NL, Stein H, Siebert R, Advani R, Ghielmini M, Salles GA, Zelenetz AD, Jaffe ES (2016) The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 127:2375–2390. https://doi.org/10.1182/blood-2016-01-643569
Sykes DB, Schroyens W, O’Connell C (2011) The TEMPI syndrome–a novel multisystem disease. N Engl J Med 365:475–477. https://doi.org/10.1056/NEJMc1106670
Treon SP, Xu L, Guerrera ML, Jimenez C, Hunter ZR, Liu X, Demos M, Gustine J, Chan G, Munshi M, Tsakmaklis N, Chen JG, Kofides A, Sklavenitis-Pistofidis R, Bustoros M, Keezer A, Meid K, Patterson CJ, Sacco A, Roccaro A, Branagan AR, Yang G, Ghobrial IM, Castillo JJ (2020) Genomic landscape of Waldenstrom macroglobulinemia and its impact on treatment strategies. J Clin Oncol 38:1198–1208. https://doi.org/10.1200/JCO.19.02314
Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies FE, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat R, Moreau P, Durie B, Stewart AK, Goldschmidt H, Raab MS, Einsele H, Sonneveld P, San Miguel J, Lonial S, Jackson GH, Anderson KC, Avet-Loiseau H, Munshi N, Thakurta A, Morgan GJ (2018) Identification of novel mutational drivers reveals oncogene dependencies in multiple myeloma. Blood 132:587–597. https://doi.org/10.1182/blood-2018-03-840132
Wang Z, Cook JR (2019) IRTA1 and MNDA expression in marginal zone lymphoma: utility in differential diagnosis and implications for classification. Am J Clin Pathol 151:337–343. https://doi.org/10.1093/ajcp/aqy144
Weiss BM, Abadie J, Verma P, Howard RS, Kuehl WM (2009) A monoclonal gammopathy precedes multiple myeloma in most patients. Blood 113:5418–5422. https://doi.org/10.1182/blood-2008-12-195008
Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S, Epstein J, Yaccoby S, Sawyer J, Burington B, Anaissie E, Hollmig K, Pineda-Roman M, Tricot G, van Rhee F, Walker R, Zangari M, Crowley J, Barlogie B, Shaughnessy JD Jr (2006) The molecular classification of multiple myeloma. Blood 108:2020–2028. https://doi.org/10.1182/blood-2005-11-013458
Funding
Open Access funding enabled and organized by Projekt DEAL.
Author information
Authors and Affiliations
Contributions
FF, AD, and JRC drafted and reviewed the manuscript and approved the final version.
Corresponding authors
Ethics declarations
Ethics approval
The authors confirm that this manuscript fulfils ethical standards.
Conflict of interest
The authors declare no competing interests.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
About this article
Cite this article
Fend, F., Dogan, A. & Cook, J.R. Plasma cell neoplasms and related entities—evolution in diagnosis and classification. Virchows Arch 482, 163–177 (2023). https://doi.org/10.1007/s00428-022-03431-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00428-022-03431-3