Abstract
Cholesteryl ester transfer protein (CETP) inhibitors are currently being investigated because of their ability to increase high-density lipoprotein cholesterol levels. In various metabolic settings, the relationship between CETP and lipoprotein metabolism is complex and may depend largely on the concentration of triglyceriderich lipoproteins. Two CETP inhibitors, JTT-705 and torcetrapib, are in an advanced phase of development. Following hopeful intermediate results, a large endpoint study using torcetrapib has just been discontinued due to increased mortality in torcetrapib-treated subjects. In this review we summarize clinical data on the use of CETP inhibitors.
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El Harchaoui, K., van der Steeg, W.A., Stroes, E.S.G. et al. The role of CETP inhibition in dyslipidemia. Curr Atheroscler Rep 9, 125–133 (2007). https://doi.org/10.1007/s11883-007-0008-5
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DOI: https://doi.org/10.1007/s11883-007-0008-5