Abstract
Introduction
We qualitatively examined the symptoms and impact of recurrent primary focal segmental glomerulosclerosis (rpFSGS) in kidney transplant recipients, compared with two related FSGS populations, to characterize the experience of patients with rpFSGS.
Methods
A literature review identified 58 articles concerning the experience of patients with pFSGS and/or rpFSGS in three groups: pre-transplant pFSGS, post-transplant rpFSGS, or post-transplant non-recurrent pFSGS. Literature findings were used to construct a preliminary conceptual model incorporating the symptoms and impact of rpFSGS, which was refined on the basis of qualitative interviews with clinicians. Twenty-five patients (rpFSGS: n = 15; pre-transplant pFSGS: n = 5; post-transplant non-recurrent pFSGS: n = 5) were interviewed to characterize the experience of patients with rpFSGS and compare it with other FSGS populations, and findings were used to finalize the conceptual model.
Results
The impact of pFSGS/rpFSGS described in the literature was diverse. Treatment-related symptoms, along with anxiety and depression, were considered important features of rpFSGS in addition to the findings from the literature review, according to clinicians. Patient-reported tiredness and swelling were the most common/disturbing symptoms associated with rpFSGS, while physical activity restrictions and adverse effects on work/social life were considered the most profound impact concepts. The collective disease experience was different for patients with rpFSGS and non-recurrent pFSGS, although psychological impact, including treatment-related anxiety and depression, were common to both groups.
Conclusions
Post-transplant recipients with rpFSGS display a greater symptom burden and experience a more diverse impact than those with non-recurrent pFSGS, highlighting the importance of effective patient monitoring and introducing effective treatments for the prevention and management of pFSGS recurrence.
Funding
Astellas Pharma Global Development, Inc.
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Introduction
Focal segmental glomerulosclerosis (FSGS) is a common cause of proteinuria and nephrotic syndrome leading to end-stage renal disease (ESRD). It refers to a group of clinicopathological syndromes characterized by focal and segmental scarring in the glomerulus [1, 2]. Although several factors are implicated in the development of FSGS, a common cause is podocyte injury [1, 3].
Worldwide, the prevalence of FSGS is increasing, although the absolute incidence and prevalence of the condition remain largely unknown [4, 5]. A systematic literature review based on studies of the incidence of primary glomerulonephritis in Europe, North and South America, Canada, Australasia, and the Middle East reported an overall incidence rate of 0.8/100,000 of the population per year for FSGS [6]. Meanwhile, a United States (US)-based population study showed that rates of FSGS had increased annually by 2.7/100,000 person-years over a 12-year observation period, with FSGS accounting for 38.9% of all primary glomerulonephropathies [7].
FSGS occurs as either primary (idiopathic) FSGS (pFSGS) or as secondary FSGS (sFSGS). pFSGS represents a major type of glomerulonephritis, accounting for about 4% of ESRD in the USA [1, 2], while sFSGS is associated with non-nephrotic proteinuria and shows less clinical severity [1]. Approximately 30–50% of pFSGS cases will recur following kidney transplantation [8], although the causal mechanisms of recurrent pFSGS (rpFSGS) remain largely unknown [4, 9].
RpFSGS is associated with an increased risk of allograft failure and its management represents a clinical challenge [4, 8, 10, 11]. High-dose corticosteroid therapy is used as first-line therapy in patients with pFSGS/rpFSGS with nephrotic-range proteinuria [12]; however, no large-scale randomized controlled trials have been conducted to corroborate their efficacy in this setting [8, 10]. Although other therapies are emerging, investigations are in their early stages and, to date, FSGS-specific proof-of-concept studies have not yet appeared in the literature.
Although studies have investigated the quality of life (QoL) burden of pFSGS [13,14,15], very few have explored the impact of disease recurrence on QoL in kidney transplant recipients. Using a three-tiered methodological approach involving a targeted literature review and qualitative interviews with clinicians and patients, this study qualitatively examined the symptoms and impact of rpFSGS in kidney transplant recipients compared with two similar populations (patients with pFSGS in native kidneys and post-transplant recipients with a history of pFSGS without disease recurrence) to characterize the experience of patients with rpFSGS and further distinguish it from other forms of FSGS.
Methods
Literature Review
A targeted literature review search was undertaken between October 4, 2016 and November 14, 2016 using MEDLINE (PubMed), Google/Google Scholar, and other select databases to identify relevant articles pertaining to the symptoms of pFSGS and/or rpFSGS and the associated impact of these conditions on patients segregated into three predefined groups: those with pre-transplant pFSGS, post-transplant rpFSGS, or post-transplant non-recurrent pFSGS. The overall search strategy consisted of disease-related terms that captured “FSGS”, “recurrent FSGS”, “early recurrence” or “late recurrence”, “proteinuria” or “nephrotic syndrome”, “hypoalbuminemia”, “hyperlipidemia”, “kidney transplant”, or “kidney disease”; and terms related to impact including “symptoms”, “clinical manifestations”, “patient-reported outcome”, “quality of life”, “emotional impact”, or “economic impact” (Table 1). In addition, searches were conducted to identify FSGS/rpFSGS-related articles on disease or kidney transplant-specific, patient-reported outcome (PRO) instruments. Google, Facebook, Twitter, and NephCure Kidney International were also searched to capture blogs or forum discussions relating specifically to patient experience.
To be eligible for inclusion, all articles had to feature one or more of the following concepts: FSGS or rpFSGS; symptoms and impact of rpFSGS or FSGS; signs, symptoms, and impact of kidney disease; QoL in kidney transplant recipients; online posts from patients with FSGS or rpFSGS; PROs pertaining to FSGS, kidney disease, or kidney transplant; treatments for rpFSGS; and the effects of those treatments. Articles were excluded if they did not provide any details on signs, symptoms, and/or impact of rpFSGS, FSGS, or associated conditions; if they concerned prognosis index scores, treatment options (subtype and genetic indicators), classification criteria, or other biological aspects of rpFSGS; or if they were focused on secondary or pediatric (< 18 years) cases of FSGS or rpFSGS, respectively. The literature review findings were used to construct a preliminary conceptual model of the signs, symptoms, and impact of rpFSGS, to be refined on the basis of clinician interviews and tested in patient interviews.
Clinician Interviews
Interviews were conducted to identify important and relevant rpFSGS concepts from a clinician’s perspective to refine the preliminary conceptual model. A total of six US physicians, including three transplant nephrologists, one clinical nephrologist, and two transplant surgeons (transplant surgeons were employees of the study sponsor), met the inclusion criteria and were invited by email to participate in a 1-h interview. Clinicians provided verbal consent for their responses to be recorded, and for the recordings to be transcribed and anonymized. A comprehensive discussion guide was designed to obtain information from clinicians regarding healthcare practice in FSGS/rpFSGS. This included questions regarding different patient populations and disease stages (including at diagnosis and pre- versus post-transplant), as well as any differentiating factors of rpFSGS compared with pFSGS (Supplementary Table S1). Symptoms and impact concepts were qualitatively compared to generate hypotheses for further investigation. No formal statistical comparison was conducted. The preliminary conceptual model was reviewed by the clinicians during the interview process to ensure the completeness and accuracy of the developed content.
Patient Interviews
Semi-structured patient interviews were conducted to elucidate the rpFSGS experience from the patient’s perspective. All patients were anonymized and provided written consent for inclusion in the study and for the results to be published. To obtain a representative sample of the general rpFSGS population, patients were recruited from a variety of sources, including the National Kidney Foundation patient advocacy group, social media networking sites (Twitter [identified by #FSGS hashtags and/or FSGS on Google search] and a personal blog), and from clinician referrals from two previously interviewed nephrologists.
For interview participation, patients with rpFSGS were required to meet the following screening criteria: a documented history of pFSGS in their native kidney, received at least one kidney transplant, and had been diagnosed with at least one recurrence of pFSGS. For comparison, kidney transplant recipients with non-recurrent pFSGS and non-kidney transplant patients with pFSGS in their native kidney(s) were also interviewed to discern the patient experience concepts unique to patients with rpFSGS. To be eligible for interview participation, patients with pFSGS and rpFSGS were required to have had pFSGS and be on the kidney transplant waiting list (pre-transplant group), have a history of pFSGS in the native kidney, or to have received at least one kidney transplant without recurrence of pFSGS (post-transplant group) at the time of study. Patients were excluded from the analysis if they had a diagnosis of sFSGS; not undergone a biopsy to confirm a diagnosis of FSGS (verbally confirmed by the patient); current (or a history of) drug addiction, alcohol abuse, or mental disability; an illness rendering them unsuitable for inclusion in the study in the opinion of the investigator; or if they were currently enrolled in a clinical trial. Demographic characteristics (age, gender, education level, and ethnicity) were collected to further characterize the groups but were not used as a means to exclude patients from the study.
To qualitatively examine the differences in the patient experience between the three groups, the predefined set of concepts (identified in the literature review and refined in the clinician interviews) was tested in each group. For patients with rpFSGS, the questions were designed to obtain information about their current symptoms and the impact of rpFSGS on their QoL, as well as to further investigate how patients’ current symptoms compare with symptoms at their worst (e.g., before receiving their first kidney transplant). Degree of disturbance on patient QoL was assessed for the different symptoms and impact concepts using patient self-assessment scores (on a scale of 0–10; where 0 indicated that the symptom or impact did not disturb the patient’s life at all and 10 indicated that the symptom or impact greatly disturbed the patient’s life). For patients with pre-transplant pFSGS, the interview focused on deriving information about current symptoms and the overall health experience relative to their condition. For patients with post-transplant non-recurrent pFSGS, interviews were centered around the presence of current or lingering symptoms and their impact post-transplant, and to explore how these symptoms (or lack of symptoms) compare with the symptoms at their worst (i.e., pre-transplant).
Compliance with Ethics Guidelines
The study was approved by the New England Independent Review Board, Needham Heights, MA, USA. This study was conducted in accordance with the ethical standards of the New England Independent Review Board and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
Results
Literature Review and Development of the Preliminary Conceptual Model
The number of publications retrieved from the literature review is shown in Table 1; of these, 58 sources (review articles [n = 13], original research articles [n = 11], online patient posts [n = 19], articles pertaining to PRO instruments [n = 11], and clinical trial results [n = 4]) were relevant to this study and included in the analysis. Overall, very few articles were identified in MEDLINE/PubMed relating to the symptoms and impact of rpFSGS compared with pFSGS. In the few articles mentioning the recurrence of pFSGS, recurrence was characterized by the same symptoms as the initial presentation of pFSGS, with little or no reference to any other health experience effects specifically attributed to disease recurrence.
Most published articles concerning “quality of life” outcomes were based on studies pertaining to the event of receiving a kidney transplant, and did not test for rpFSGS (or pFSGS) other than assessing changes in QoL attributed to the actual kidney transplant. As no literature was identified for either pre- or post-transplant non-recurrent patients with pFSGS, chronic kidney disease/ESRD and kidney transplant populations, respectively, were used as proxies for these groups to generate hypotheses surrounding the potential rpFSGS experience.
The literature review findings enabled the development of a preliminary conceptual model of the experience of patients with rpFSGS (Fig. 1). The most frequently reported symptoms in the literature for rpFSGS and/or patients with kidney disease were wide-ranging and included “fatigue/tiredness”, “proteinuria/foamy urine”, “loss of strength”, “muscle loss”, “muscle weakness”, and “edema” [13, 16,17,18]. Symptoms associated with rpFSGS and treatment (i.e., steroids, immunosuppressants, and rituximab use) in the literature, and in the prescribing information for these therapies include “bone/joint pain”, “diarrhea”, “dizziness”, “fatigue/tiredness”, and “headaches” [19,20,21,22,23].
On the basis of published literature, patients with rpFSGS and/or the wider transplant population also seem to experience immediate and generalized impact concepts including “anxiety”, “decreased social functioning”, and “depression” [14, 16, 24, 25]. Impact concepts considered predominantly associated with treatment in patients with kidney disease (but not specific to patients with rpFSGS) included “appetite/weight gain” (associated with corticosteroid use); “decreased satisfaction with appearance” (in patients receiving corticosteroid and immunosuppressant therapy); “nonadherence” and “pill burden” (in patients with poor renal function following transplantation); and “caregiver burden”, “withdrawal from dialysis”, and “decreased satisfaction with social support network” (in patients receiving dialysis) [21, 26,27,28,29].
Online posts from FSGS patients (n = 19) confirmed many of the aforementioned symptoms and subsequent effects reported in the literature for rpFSGS and patients with kidney disease; in addition, disease-related factors not reported in the current literature were described in online patient posts and were subsequently incorporated into the rpFSGS conceptual model. These included “frequent urination”, “mood swings”, and “shakiness” as symptoms, and “financial difficulty”, “denial”, “extreme disappointment”, and “feelings of hopelessness” as impact concepts [17, 30,31,32,33]. Impact concepts referenced in online patient forum discussions/blogs and considered to be both disease- and treatment-related included “aggression/irritableness”, “reduced work productivity/inability to work”, and “weight/appetite loss” [17, 30,31,32,33].
Clinician Interviews and Refinement of the Conceptual Model
Building on the literature review findings, clinicians perceived the range of symptoms experienced and degree of symptom burden to vary significantly from patient to patient, with some displaying a more aggressive disease course than others. Moreover, the timing of symptom presentation was said to vary among patients with rpFSGS, with some being diagnosed in a delayed fashion during routine post-transplant monitoring. Additionally, dialysis and other treatments, including immunosuppressive therapies, rituximab, and plasmapheresis, were also discussed with clinicians; this highlighted a need to consider the wider impact, including the broader psychological implications of these treatments, on patients with rpFSGS. From the clinician’s perspective, suffering a recurrence of rpFSGS was regarded as “devastating” for the patient after having recently undergone transplantation. For this reason, the consequences of the condition were regarded as being potentially magnified beyond that of pFSGS.
On the basis of clinician feedback, three main refinements were made to the preliminary conceptual model of the experience of patients with rpFSGS: (1) the overall range of condition-related symptoms was narrowed, on the basis of the clinicians’ views that symptoms are not typically as broad as suggested by the literature; (2) a wider range of treatment-related symptoms was introduced, on the basis of the insight that treatment for rpFSGS extends beyond that of steroid use; and (3) the impact related to anxiety and depression was further explored following the consideration that these mental health disorders have broad meanings and implications.
Patient Interviews: Demographics
In total, 25 patients were recruited from the National Kidney Foundation’s patient advocacy groups (n = 17), social media networking sites (Twitter [identified by #FSGS hashtags and/or “FSGS” on Google search]: n = 4; blog: n = 1), and from clinician referrals from two previously interviewed nephrologists (n = 3).
Demographics of interviewed patients with rpFSGS (n = 15), pre-transplant pFSGS (n = 5), and post-transplant non-recurrent pFSGS (n = 5) are shown in Table 2.
Patient Interviews: Symptoms of rpFSGS Graded by Disturbance
Figure 2a presents an overview of rpFSGS symptoms, shows how frequently each was reported in the patient interviews, and the average patient-reported degree of disturbance on patient QoL. Additional context is provided with representative patient quotes (Table 3). The most salient symptoms were considered to be those that were both frequently reported and rated as being highly disturbing. For patients with rpFSGS, the most salient reported symptoms were tiredness, swelling, shortness of breath, loss of appetite, and dry, itchy skin. “Tiredness” was the most commonly reported symptom, reported by most patients (14/15 mentions) with rpFSGS. Tiredness had a profound negative impact on activities of daily living and represented one of the most disturbing symptoms (Fig. 2a; Table 3). It was further noted as being distinct from “physical weakness”.
Swelling (11/15 mentions), also referred to by patients as “edema”, “bloating”, or “puffiness”, was also reported as a common and disturbing symptom of rpFSGS (Fig. 2a; Table 3). In addition, swelling was considered to be one of the few symptoms experienced by patients at the time of diagnosis, and was noted to manifest in different locations of the body, including the feet, calves, legs, stomach, hands, face, around the eyes, and cheeks. Patients also indicated that dialysis helped to alleviate the severity of the swelling. Shortness of breath (10/15 mentions), appetite loss (11/15 mentions), and dry or itchy skin (13/15 mentions) were also perceived to be common and disturbing symptoms of rpFSGS (Fig. 2a; Table 3).
Overall, 11 out of 15 interviewed patients noted the presence of “foamy or bubbly urine” and/or “decreased urination” as a symptom of rpFSGS, with the former being described in the literature and by clinicians as a hallmark of rpFSGS, resulting from proteinuria [34,35,36,36]. Indeed, of the five patients with non-recurrent pFSGS and who were interviewed, none experienced proteinuria post-transplant. All patients with rpFSGS who experienced “foamy or bubbly urine” (9/15 mentions) reported that it became more noticeable as the disease worsened, while patients who experienced “decreased urination” (9/15 mentions), even to the point of absent urination following progression to ESRD, often made the association between the symptom and degree of remaining kidney function (Table 3). Despite the connections made by some patients between the presence of “foamy or bubbly urine” or “decreased urination” and the underlying severity of their condition, patients, on average, rated these symptoms as being relatively low in disturbance (3.0/10 and 3.7/10, respectively; Fig. 2a).
Patient Interviews: Impact Concepts in rpFSGS and Disturbance Ranking
An overview of all rpFSGS impact concepts, along with their frequency of mention and the average patient-reported degree of disturbance, can be found in Fig. 2b, with representative quotes in Table 3. The most salient impact concepts (high frequency and high disturbance rating) were limitations/difficulties performing physical acts, unable to work or be productive at work, less frequent social interactions, anxiety, and frustration. The limitation in physical activity (reported by patients as being mainly due to tiredness or lack of energy) was the most frequently experienced impact of rpFSGS (13/15 mentions), and was also reported to restrict recreational activities (Fig. 2b; Table 3). A decreasing ability to perform these activities because of their condition was a major concern for patients, as reflected by high disturbance rating scores.
Similarly, patients also discussed the significant detrimental effect of rpFSGS on their work productivity and social life (11/15 mentions; Fig. 2b; Table 3). Patients reported experiencing generalized anxiety (11/15 mentions) as a result of needing to manage their rpFSGS and treatment, along with a feeling of uncertainty about their future, regarding this as a fairly disturbing feature of their condition (Fig. 2b; Table 3). Depression or depressed feelings were commonly linked to anxiety in these patients, with approximately half of all interviewees having sought professional help from a therapist or having received psychiatric medication to cope with their feelings of anxiety or depression. In addition to no longer being able to perform the activities they once enjoyed as a result of physical restrictions imposed by their condition, patients also sensed related feelings of frustration (11/15 mentions) associated with an overwhelming sense of powerlessness (Fig. 2b; Table 3).
Patient Interviews: rpFSGS and pFSGS Comparison
In this study, although patients with rpFSGS and those with pFSGS (pre-transplant) reported the same symptoms and adverse impact (Table 4), the frequency of mention and patient-reported degree of disturbance differed between groups. Patients with rpFSGS, having already undergone a major surgical procedure to overcome their condition, appeared to be more acutely aware of their symptoms and perceived them differently compared with the original pFSGS symptoms they experienced. For example, one patient noted that “I wouldn’t say that the symptoms are any different. I’m just more aware of it this time because I actually know what’s going on and I’m more tuned into my body”. In addition to heightened awareness of the impact of the condition, this finding could also be due to the influence of confounding factors such as age, longer duration of disease, and the influence or benefit of treatment.
As expected, post-transplant patients with non-recurrent pFSGS experienced fewer symptoms compared with those with rpFSGS (Table 4). Although this study identified four symptoms that were common in both groups (diarrhea, dizziness, nausea, and shakiness), the most salient symptoms experienced by patients with rpFSGS were not present in those without recurrence post transplant. As reported in the literature, diarrhea, dizziness, and nausea are considered to be rpFSGS-related and also treatment-related [19,20,21,22,23], suggesting that the lingering symptoms experienced by non-recurrent patients are predominantly treatment-related. The finding that tiredness, swelling, shortness of breath, loss of appetite, and dry, itchy skin were frequently reported and judged as highly disturbing by patients with rpFSGS, but not reported at all by patients with non-recurrent pFSGS, highlights the unmet need among the population of patients with rpFSGS.
Disease impact was limited in the non-recurrent post-transplant recipients (Table 4), particularly in comparison with both the rpFSGS and the pre-transplant pFSGS groups. The only reported impact concepts among patients with post-transplant non-recurrent pFSGS were anxiety, hopelessness/lack of motivation, and stress from treatment schedule. Although anxiety was frequently reported in both the rpFSGS and non-recurrent pFSGS groups, non-recurrent patients notably cited the fear of recurrence as a cause of their anxiety. Similarly, feelings of hopelessness and decreased motivation were documented in both groups but were attributed to a lack of confidence in remaining FSGS-free in the non-recurrent pFSGS group. Both rpFSGS and non-recurrent rpFSGS groups experienced psychological stress as a result of an intense post-transplant treatment schedule. In the absence of recurrence, the functional, emotional, and psychological concepts associated with pFSGS were considered to eventually dissipate, with patients resuming a normal QoL. By contrast, patients with rpFSGS recalled a profoundly negative emotional and psychological impact when informed that their disease had recurred (Table 3).
Finalization of the Conceptual Model
The findings from the literature review, refined via clinician interviews and tested in patient interviews, contributed towards the development of the finalized conceptual model for rpFSGS (Fig. 3).
Discussion
Importantly, although the majority of patients with rpFSGS (9/15) in our study reported experiencing “foamy/bubbly urine” and reported that it became more noticeable as the disease worsened, they did not rate this symptom as being highly disturbing. Therefore, even though “foamy/bubbly urine” may be a hallmark feature of rpFSGS [34,35,36], it does not seem to have much impact on patient QoL. Our results showed that the most salient symptoms—those that were reported most frequently and rated as most disturbing—are tiredness, swelling, appetite loss, dry and/or itchy skin, and shortness of breath.
Physical limitations and difficulties meeting the challenges of daily life activities, along with the impact of rpFSGS on patients’ professional and social lives, were prevalent in this patient population, and were particularly disturbing for patients. Anxiety and feelings of frustration were commonly reported among patients with rpFSGS, and were inherently associated with a fear of the unknown and the inability to exert control over their condition or future.
In this study, patients with rpFSGS could not be differentiated qualitatively from those with pFSGS in native kidneys on the basis of their symptom/impact profiles alone, with patients with rpFSGS reporting the same symptoms and associated impact as those with pFSGS. Therefore, it appears that rpFSGS may prevent these patients from experiencing symptom relief post-transplant. However, some of the interviewed patients with rpFSGS perceived their current disease experience differently compared with how they felt when the condition was first diagnosed. By contrast, the severity of symptoms and overall impact appear to be markedly different in patients with rpFSGS compared with patients with non-recurrent pFSGS (post transplant). Unlike patients with rpFSGS, patients who were FSGS-free became almost asymptomatic post transplant, had only a few lingering psychological manifestations (anxiety or fear of recurrence, and stress linked to post-transplant treatment), and were largely able to resume a normal life.
There were several limitations associated with the patient interviews conducted in this analysis, and inherent biases may have skewed the results. Selection bias may have occurred, as the patients interviewed were members of a patient advocacy organization; given their engagement in active disease management through advocacy participation, they may have been more attuned to signs, symptoms, and impact associated with rpFSGS. Likewise, such patients may have been more open about their condition compared with the general rpFSGS population. Similarly, patient age and disease duration were also factors that may have influenced patient response. For example, older patients may associate certain symptoms (e.g., tiredness, physical limitations/difficulties, and decreased libido) with age, and may therefore find them less disturbing than younger patients. Patients who have had the disease for a longer duration may also be more accustomed to their illness and may be more (or less) sensitive to disease- and/or treatment-related impact. Owing to the aforementioned factors and the relatively small sample sizes used in this analysis, it was not possible to fully differentiate the symptom/impact profile of patients with rpFSGS from patients with pre-transplant pFSGS and post-transplant non-recurrent pFSGS. However, on the basis of these findings, we identified some important differences that provide scope for further research, including the possibility of future PRO instrument development for use in populations of patients with FSGS.
Conclusion
Post-transplant recipients with rpFSGS display an overall greater symptom burden and experience a wider range of impact concepts compared with patients without disease recurrence, highlighting the unmet need in patients with rpFSGS. We observed that the symptoms and overall impact of rpFSGS largely resemble those observed in patients with pFSGS in their native kidney. Overall, the results of this study emphasize the importance of monitoring patients for recurrence after transplant surgery and developing effective treatments to prevent and manage recurrence in the FSGS setting.
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Acknowledgements
The authors would like to thank the participants of the study and Karen Kariv for her valuable contributions to the study and to the development of this manuscript.
Funding
This study was funded by Astellas Pharma Global Development, Inc. The Rapid Service and Open Access Fees were also funded by Astellas Pharma Global Development, Inc.
Medical Writing Assistance
Medical writing support in the development of this manuscript was provided by Robyn Fowler and Matthew Reynolds from OPEN Health Medical Communications (London, UK), funded by Astellas Pharma Global Development, Inc.
Authorship
All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.
Disclosures
Marci English is an employee of employees of Astellas Pharma Global Development, Inc. Mysore S. A. Kumar is an employee of Astellas Pharma Global Development, Inc. Jason Schwartz is an employee of Astellas Pharma Global Development, Inc. Emily Hawryluk is an employee of IQVIA, who was contracted by Astellas Pharma Global Development, Inc. to provide support for this study. Robert Krupnick is an employee of IQVIA, who was contracted by Astellas Pharma Global Development, Inc. to provide support for this study.
Compliance with Ethics Guidelines
The study was approved by the New England Independent Review Board, Needham Heights, MA, USA. This study was conducted in accordance with the ethical standards of the New England Independent Review Board and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.
Data Availability
Access to anonymized individual participant level data will not be provided for this trial because it meets one or more of the exceptions described on http://www.clinicalstudydatarequest.com under “Sponsor Specific Details for Astellas”.
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English, M., Hawryluk, E., Krupnick, R. et al. The Symptoms and Impact of Recurrent Focal Segmental Glomerulosclerosis in Kidney Transplant Recipients: A Conceptual Model of the Patient Experience. Adv Ther 36, 3390–3408 (2019). https://doi.org/10.1007/s12325-019-01110-5
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DOI: https://doi.org/10.1007/s12325-019-01110-5